Evaluation of subchronic toxicity of the compound of diphenhydramine hydrochloride and caffeine after 28 days of repeated oral administration in Sprague-Dawley rats and beagle dogs
This study was designed to evaluate the subchronic toxicity of the compound of diphenhydramine hydrochloride (DH) and caffeine in Sprague-Dawley (SD) rats and beagle dogs. A total of 180 SD rats (15/sex/group) were randomly divided into the compound low-, medium- and high-dose groups (51, 102, 204 mg/kg), DH group (60 mg/kg), caffeine group (144 mg/kg) and the vehicle control group. Sixty beagle dogs (5/sex/group) were randomly divided into the compound low-, medium- and high-dose groups (male: 14.20, 28.30, 56.60 mg/kg, female: 5.66, 14.20, 28.30 mg/kg), DH group (male: 16.60 mg/kg, female: 8.30 mg/kg), caffeine group (male: 40.00 mg/kg, female: 20.00 mg/kg) and the vehicle control group. Rats and dogs were given continuous oral administration for 28 days following a 28-day recovery period. The adverse effects of the compound on rats and beagle dogs mainly included anorexia and liver function impairment. Most adverse effects induced by administration were reversible. Under the experimental conditions, the no-observed-adverse-effect level (NOAEL) of the compound of DH and caffeine was 51 mg/kg/day for SD rats and 28.30 mg/kg/day (male) and 5.66 mg/kg/day (female) for beagle dogs.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:46 |
|---|---|
| Enthalten in: |
Drug and chemical toxicology - 46(2023), 6 vom: 17. Nov., Seite 1083-1099 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Ren, Lijun [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
3G6A5W338E |
|---|
| Anmerkungen: |
Date Completed 05.09.2023 Date Revised 05.09.2023 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1080/01480545.2022.2129674 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM348977603 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM348977603 | ||
| 003 | DE-627 | ||
| 005 | 20231226041549.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1080/01480545.2022.2129674 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1163.xml |
| 035 | |a (DE-627)NLM348977603 | ||
| 035 | |a (NLM)36384384 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Ren, Lijun |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Evaluation of subchronic toxicity of the compound of diphenhydramine hydrochloride and caffeine after 28 days of repeated oral administration in Sprague-Dawley rats and beagle dogs |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 05.09.2023 | ||
| 500 | |a Date Revised 05.09.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a This study was designed to evaluate the subchronic toxicity of the compound of diphenhydramine hydrochloride (DH) and caffeine in Sprague-Dawley (SD) rats and beagle dogs. A total of 180 SD rats (15/sex/group) were randomly divided into the compound low-, medium- and high-dose groups (51, 102, 204 mg/kg), DH group (60 mg/kg), caffeine group (144 mg/kg) and the vehicle control group. Sixty beagle dogs (5/sex/group) were randomly divided into the compound low-, medium- and high-dose groups (male: 14.20, 28.30, 56.60 mg/kg, female: 5.66, 14.20, 28.30 mg/kg), DH group (male: 16.60 mg/kg, female: 8.30 mg/kg), caffeine group (male: 40.00 mg/kg, female: 20.00 mg/kg) and the vehicle control group. Rats and dogs were given continuous oral administration for 28 days following a 28-day recovery period. The adverse effects of the compound on rats and beagle dogs mainly included anorexia and liver function impairment. Most adverse effects induced by administration were reversible. Under the experimental conditions, the no-observed-adverse-effect level (NOAEL) of the compound of DH and caffeine was 51 mg/kg/day for SD rats and 28.30 mg/kg/day (male) and 5.66 mg/kg/day (female) for beagle dogs | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Subchronic toxicity | |
| 650 | 4 | |a caffeine | |
| 650 | 4 | |a diphenhydramine hydrochloride | |
| 650 | 4 | |a dog | |
| 650 | 4 | |a rat | |
| 650 | 7 | |a Caffeine |2 NLM | |
| 650 | 7 | |a 3G6A5W338E |2 NLM | |
| 650 | 7 | |a Diphenhydramine |2 NLM | |
| 650 | 7 | |a 8GTS82S83M |2 NLM | |
| 700 | 1 | |a Yan, Lang |e verfasserin |4 aut | |
| 700 | 1 | |a Shi, Wenjing |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Tiantian |e verfasserin |4 aut | |
| 700 | 1 | |a Geng, Bijiang |e verfasserin |4 aut | |
| 700 | 1 | |a Mao, Jingjing |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Jiqianzhu |e verfasserin |4 aut | |
| 700 | 1 | |a Tian, Yijun |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Haoneng |e verfasserin |4 aut | |
| 700 | 1 | |a Gao, Fangyuan |e verfasserin |4 aut | |
| 700 | 1 | |a Dai, Xiaoyu |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Jinfeng |e verfasserin |4 aut | |
| 700 | 1 | |a Gu, Jing |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Yun |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Xiaofang |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Jikuai |e verfasserin |4 aut | |
| 700 | 1 | |a Zhu, Jiangbo |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Drug and chemical toxicology |d 1984 |g 46(2023), 6 vom: 17. Nov., Seite 1083-1099 |w (DE-627)NLM000913685 |x 1525-6014 |7 nnns |
| 773 | 1 | 8 | |g volume:46 |g year:2023 |g number:6 |g day:17 |g month:11 |g pages:1083-1099 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1080/01480545.2022.2129674 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 46 |j 2023 |e 6 |b 17 |c 11 |h 1083-1099 | ||