Systematic review of primary and booster COVID-19 sera neutralizing ability against SARS-CoV-2 omicron variant
© 2022. The Author(s)..
Virus neutralization data using post-vaccination sera are an important tool in informing vaccine use policy decisions, however, they often pose interpretive challenges. We systematically reviewed the pre-print and published literature for neutralization studies against Omicron using sera collected after both primary and booster vaccination. We found a high proportion of post-primary vaccination sera were not responding against Omicron but boosting increased both neutralizing activity and percent of responding sera. We recommend reporting percent of responders alongside neutralization data to portray vaccine neutralization ability more accurately.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:7 |
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| Enthalten in: |
NPJ vaccines - 7(2022), 1 vom: 15. Nov., Seite 147 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Sitaras, Ioannis [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Revised 20.11.2022 published: Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1038/s41541-022-00565-y |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM348933452 |
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| 520 | |a Virus neutralization data using post-vaccination sera are an important tool in informing vaccine use policy decisions, however, they often pose interpretive challenges. We systematically reviewed the pre-print and published literature for neutralization studies against Omicron using sera collected after both primary and booster vaccination. We found a high proportion of post-primary vaccination sera were not responding against Omicron but boosting increased both neutralizing activity and percent of responding sera. We recommend reporting percent of responders alongside neutralization data to portray vaccine neutralization ability more accurately | ||
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