Preterm birth and weight-for-gestational age for risks of autism spectrum disorder and intellectual disability : A nationwide population-based cohort study
Copyright © 2022 Formosan Medical Association. Published by Elsevier B.V. All rights reserved..
PURPOSE: To evaluate gestational age (GA) and small-for-gestational age (SGA) as continuums and gender on the incidences of autism spectrum disorder (ASD) and co-occurring intellectual disability (ID).
METHODS: This is a population-based cohort study using the 2004-2008 Taiwan Maternal and Child Health Database. The diagnosis of ASD was determined by International Classification of Diseases, 9th Revision (ICD-9). Generalized estimating equations models were fit to evaluate associations between perinatal variables and ASD.
RESULTS: This study included 916,315 individuals. A total of 9474 (1.0%) children were diagnosed with ASD, among whom 1594 (16.8%) had co-occurring ID. Lower GA carried higher odds of ASD with ID (GA < 28 weeks, aOR: 4.26, 95% CI: 2.13, 8.50; GA 28-30 weeks, aOR: 2.80, 95% CI: 1.57, 4.97; GA 31-33 weeks, aOR: 1.63, 95% CI: 1.05, 2.55; GA 34-36 weeks, aOR: 1.39, 95% CI: 1.16, 1.67) and ASD without ID (GA < 28 weeks, aOR:2.05, 95% CI: 1.25, 3.36; GA 28-30 weeks, aOR: 2.02, 95% CI: 1.46, 2.79; GA 31-33 weeks, aOR: 1.42, 95% CI: 1.13, 1.77; GA 34-36 weeks, aOR: 1.18, 95% CI: 1.08, 1.29). Male preterm infants had ASD risks negatively correlated to GA, while ASD risks were significantly increased only among female infants born late preterm. The degree of SGA showed a stepwise increased risk for ASD with and without ID in both male and female infants.
CONCLUSION: Lower GA and the degree of SGA are both associated with ASD susceptibility, either with or without co-occurring ID, and remarkably increased the risk of ID.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:122 |
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| Enthalten in: |
Journal of the Formosan Medical Association = Taiwan yi zhi - 122(2023), 6 vom: 12. Juni, Seite 493-504 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Chang, Yu-Shan [VerfasserIn] |
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| Links: |
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| Themen: |
Autism spectrum disorder |
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| Anmerkungen: |
Date Completed 22.05.2023 Date Revised 22.05.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.jfma.2022.10.005 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM348848153 |
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| 100 | 1 | |a Chang, Yu-Shan |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Preterm birth and weight-for-gestational age for risks of autism spectrum disorder and intellectual disability |b A nationwide population-based cohort study |
| 264 | 1 | |c 2023 | |
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| 500 | |a Date Completed 22.05.2023 | ||
| 500 | |a Date Revised 22.05.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2022 Formosan Medical Association. Published by Elsevier B.V. All rights reserved. | ||
| 520 | |a PURPOSE: To evaluate gestational age (GA) and small-for-gestational age (SGA) as continuums and gender on the incidences of autism spectrum disorder (ASD) and co-occurring intellectual disability (ID) | ||
| 520 | |a METHODS: This is a population-based cohort study using the 2004-2008 Taiwan Maternal and Child Health Database. The diagnosis of ASD was determined by International Classification of Diseases, 9th Revision (ICD-9). Generalized estimating equations models were fit to evaluate associations between perinatal variables and ASD | ||
| 520 | |a RESULTS: This study included 916,315 individuals. A total of 9474 (1.0%) children were diagnosed with ASD, among whom 1594 (16.8%) had co-occurring ID. Lower GA carried higher odds of ASD with ID (GA < 28 weeks, aOR: 4.26, 95% CI: 2.13, 8.50; GA 28-30 weeks, aOR: 2.80, 95% CI: 1.57, 4.97; GA 31-33 weeks, aOR: 1.63, 95% CI: 1.05, 2.55; GA 34-36 weeks, aOR: 1.39, 95% CI: 1.16, 1.67) and ASD without ID (GA < 28 weeks, aOR:2.05, 95% CI: 1.25, 3.36; GA 28-30 weeks, aOR: 2.02, 95% CI: 1.46, 2.79; GA 31-33 weeks, aOR: 1.42, 95% CI: 1.13, 1.77; GA 34-36 weeks, aOR: 1.18, 95% CI: 1.08, 1.29). Male preterm infants had ASD risks negatively correlated to GA, while ASD risks were significantly increased only among female infants born late preterm. The degree of SGA showed a stepwise increased risk for ASD with and without ID in both male and female infants | ||
| 520 | |a CONCLUSION: Lower GA and the degree of SGA are both associated with ASD susceptibility, either with or without co-occurring ID, and remarkably increased the risk of ID | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Autism spectrum disorder | |
| 650 | 4 | |a Gestational age | |
| 650 | 4 | |a Intellectual disability | |
| 650 | 4 | |a Premature | |
| 650 | 4 | |a Sex factors | |
| 700 | 1 | |a Chen, Li-Wen |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Tsung |e verfasserin |4 aut | |
| 700 | 1 | |a Lin, Sheng-Hsiang |e verfasserin |4 aut | |
| 700 | 1 | |a Kuo, Pao-Lin |e verfasserin |4 aut | |
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