Second-Line Chemotherapy in Elderly Patients with Advanced Biliary Tract Cancer : A Multicenter Real-World Study
Objectives: The ABC-06 and the NIFTY trials recently established the role of second-line chemotherapy (2L) in patients with advanced biliary tract cancer (BTC). Our real-world study aimed to explore 2L in BTC patients aged ≥ 70 years old and to compare their outcomes with younger subjects. Methods: Institutional registries across three academic medical centers were retrospectively reviewed. The Kaplan−Meier methods were used to estimate survival, and the log-rank test was used to make comparisons. Results: A total of 190 BTC patients treated with 2L were identified and included in the analysis. Among them, 52 (27.3%) were aged ≥ 70 years (range 70−87 years). No statistically significant differences in both median overall survival (mOS) and median progression-free survival (mPFS) were recorded between the elderly and younger patients. Absolute lymphocyte count < 1000/mmc (p < 0.001) and albumin level < 3 g/dL (p < 0.001) were independently associated with worse prognoses. Conclusions: The results of this real-world study suggest that for patients aged ≥ 70 years, 2L could be equally effective for younger patients with survival outcomes aligned to those from the ABC-06 and NIFTY trials. The delivery of 2L should be carefully evaluated and monitored in this patient subset.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2022 |
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Erschienen: |
2022 |
Enthalten in: |
Zur Gesamtaufnahme - volume:58 |
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Enthalten in: |
Medicina (Kaunas, Lithuania) - 58(2022), 11 vom: 27. Okt. |
Sprache: |
Englisch |
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Beteiligte Personen: |
Rizzo, Alessandro [VerfasserIn] |
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Links: |
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Themen: |
Biliary tract cancer |
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Anmerkungen: |
Date Completed 14.11.2022 Date Revised 08.03.2023 published: Electronic Citation Status MEDLINE |
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doi: |
10.3390/medicina58111543 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM348770855 |
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