Regulatory T cells as metabolic sensors
Copyright © 2022 Elsevier Inc. All rights reserved..
Compelling experimental evidence links immunity and metabolism. In this perspective, we propose forkhead-box-P3 (FoxP3)+CD4+CD25+ regulatory T (Treg) cells as key metabolic sensors controlling the immunological state in response to their intrinsic capacity to perceive nutritional changes. Treg cell high anabolic state in vivo, residency in metabolically crucial districts, and recirculation between lymphoid and non-lymphoid sites enable them to recognize the metabolic cues and adapt their intracellular metabolism and anti-inflammatory function at the paracrine and systemic levels. As privileged regulators at the interface between neuroendocrine and immune systems, the role of Treg cells in maintaining metabolic homeostasis makes these cells promising targets of therapeutic strategies aimed at restoring organismal homeostasis not only in autoimmune but also metabolic disorders.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2022 |
|---|---|
| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:55 |
|---|---|
| Enthalten in: |
Immunity - 55(2022), 11 vom: 08. Nov., Seite 1981-1992 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
de Candia, Paola [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Autoimmunity |
|---|
| Anmerkungen: |
Date Completed 11.11.2022 Date Revised 12.12.2022 published: Print Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.immuni.2022.10.006 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM348649959 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM348649959 | ||
| 003 | DE-627 | ||
| 005 | 20231226040750.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.immuni.2022.10.006 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1162.xml |
| 035 | |a (DE-627)NLM348649959 | ||
| 035 | |a (NLM)36351373 | ||
| 035 | |a (PII)S1074-7613(22)00547-7 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a de Candia, Paola |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Regulatory T cells as metabolic sensors |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 11.11.2022 | ||
| 500 | |a Date Revised 12.12.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2022 Elsevier Inc. All rights reserved. | ||
| 520 | |a Compelling experimental evidence links immunity and metabolism. In this perspective, we propose forkhead-box-P3 (FoxP3)+CD4+CD25+ regulatory T (Treg) cells as key metabolic sensors controlling the immunological state in response to their intrinsic capacity to perceive nutritional changes. Treg cell high anabolic state in vivo, residency in metabolically crucial districts, and recirculation between lymphoid and non-lymphoid sites enable them to recognize the metabolic cues and adapt their intracellular metabolism and anti-inflammatory function at the paracrine and systemic levels. As privileged regulators at the interface between neuroendocrine and immune systems, the role of Treg cells in maintaining metabolic homeostasis makes these cells promising targets of therapeutic strategies aimed at restoring organismal homeostasis not only in autoimmune but also metabolic disorders | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Treg cells | |
| 650 | 4 | |a autoimmunity | |
| 650 | 4 | |a immunometabolism | |
| 650 | 4 | |a metabolic disease | |
| 650 | 7 | |a Forkhead Transcription Factors |2 NLM | |
| 650 | 7 | |a Interleukin-2 Receptor alpha Subunit |2 NLM | |
| 700 | 1 | |a Procaccini, Claudio |e verfasserin |4 aut | |
| 700 | 1 | |a Russo, Claudia |e verfasserin |4 aut | |
| 700 | 1 | |a Lepore, Maria Teresa |e verfasserin |4 aut | |
| 700 | 1 | |a Matarese, Giuseppe |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Immunity |d 1994 |g 55(2022), 11 vom: 08. Nov., Seite 1981-1992 |w (DE-627)NLM075097818 |x 1097-4180 |7 nnns |
| 773 | 1 | 8 | |g volume:55 |g year:2022 |g number:11 |g day:08 |g month:11 |g pages:1981-1992 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.immuni.2022.10.006 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 55 |j 2022 |e 11 |b 08 |c 11 |h 1981-1992 | ||