2022 American College of Rheumatology/EULAR Classification Criteria for Giant Cell Arteritis
© 2022 American College of Rheumatology..
OBJECTIVE: To develop and validate updated classification criteria for giant cell arteritis (GCA).
METHODS: Patients with vasculitis or comparator diseases were recruited into an international cohort. The study proceeded in 6 phases: 1) identification of candidate items, 2) prospective collection of candidate items present at the time of diagnosis, 3) expert panel review of cases, 4) data-driven reduction of candidate items, 5) derivation of a points-based risk classification score in a development data set, and 6) validation in an independent data set.
RESULTS: The development data set consisted of 518 cases of GCA and 536 comparators. The validation data set consisted of 238 cases of GCA and 213 comparators. Age ≥50 years at diagnosis was an absolute requirement for classification. The final criteria items and weights were as follows: positive temporal artery biopsy or temporal artery halo sign on ultrasound (+5); erythrocyte sedimentation rate ≥50 mm/hour or C-reactive protein ≥10 mg/liter (+3); sudden visual loss (+3); morning stiffness in shoulders or neck, jaw or tongue claudication, new temporal headache, scalp tenderness, temporal artery abnormality on vascular examination, bilateral axillary involvement on imaging, and fluorodeoxyglucose-positron emission tomography activity throughout the aorta (+2 each). A patient could be classified as having GCA with a cumulative score of ≥6 points. When these criteria were tested in the validation data set, the model area under the curve was 0.91 (95% confidence interval [95% CI] 0.88-0.94) with a sensitivity of 87.0% (95% CI 82.0-91.0%) and specificity of 94.8% (95% CI 91.0-97.4%).
CONCLUSION: The 2022 American College of Rheumatology/EULAR GCA classification criteria are now validated for use in clinical research.
Errataetall: |
CommentIn: Arthritis Rheumatol. 2023 Jun;75(6):1075-1077. - PMID 36622332 |
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Medienart: |
E-Artikel |
Erscheinungsjahr: |
2022 |
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Erschienen: |
2022 |
Enthalten in: |
Zur Gesamtaufnahme - volume:74 |
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Enthalten in: |
Arthritis & rheumatology (Hoboken, N.J.) - 74(2022), 12 vom: 07. Dez., Seite 1881-1889 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Ponte, Cristina [VerfasserIn] |
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Anmerkungen: |
Date Completed 16.12.2022 Date Revised 14.02.2024 published: Print-Electronic CommentIn: Arthritis Rheumatol. 2023 Jun;75(6):1075-1077. - PMID 36622332 Citation Status MEDLINE |
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doi: |
10.1002/art.42325 |
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funding: |
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PPN (Katalog-ID): |
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500 | |a published: Print-Electronic | ||
500 | |a CommentIn: Arthritis Rheumatol. 2023 Jun;75(6):1075-1077. - PMID 36622332 | ||
500 | |a Citation Status MEDLINE | ||
520 | |a © 2022 American College of Rheumatology. | ||
520 | |a OBJECTIVE: To develop and validate updated classification criteria for giant cell arteritis (GCA) | ||
520 | |a METHODS: Patients with vasculitis or comparator diseases were recruited into an international cohort. The study proceeded in 6 phases: 1) identification of candidate items, 2) prospective collection of candidate items present at the time of diagnosis, 3) expert panel review of cases, 4) data-driven reduction of candidate items, 5) derivation of a points-based risk classification score in a development data set, and 6) validation in an independent data set | ||
520 | |a RESULTS: The development data set consisted of 518 cases of GCA and 536 comparators. The validation data set consisted of 238 cases of GCA and 213 comparators. Age ≥50 years at diagnosis was an absolute requirement for classification. The final criteria items and weights were as follows: positive temporal artery biopsy or temporal artery halo sign on ultrasound (+5); erythrocyte sedimentation rate ≥50 mm/hour or C-reactive protein ≥10 mg/liter (+3); sudden visual loss (+3); morning stiffness in shoulders or neck, jaw or tongue claudication, new temporal headache, scalp tenderness, temporal artery abnormality on vascular examination, bilateral axillary involvement on imaging, and fluorodeoxyglucose-positron emission tomography activity throughout the aorta (+2 each). A patient could be classified as having GCA with a cumulative score of ≥6 points. When these criteria were tested in the validation data set, the model area under the curve was 0.91 (95% confidence interval [95% CI] 0.88-0.94) with a sensitivity of 87.0% (95% CI 82.0-91.0%) and specificity of 94.8% (95% CI 91.0-97.4%) | ||
520 | |a CONCLUSION: The 2022 American College of Rheumatology/EULAR GCA classification criteria are now validated for use in clinical research | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Research Support, N.I.H., Intramural | |
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