Fluorinated covalent organic frameworks for efficient drug delivery
This journal is © The Royal Society of Chemistry..
In this study, two novel fluorine-functionalized crystalline covalent organic frameworks (COFs), namely DF-TAPB-COF and DF-TATB-COF, were synthesized, and their ordered structure, porosity, suitable pore size, and abundant fluorine groups were expected to serve as effective carriers in drug delivery. The excellent cell viability of DF-TAPB-COF and DF-TATB-COF was verified using MTT assays. Both COFs exhibited very high loading capacities in terms of drug loading performance, in particular the drug loading rate of DF-TAPB-COF for 5-fluorouracil (5-FU) was up to 69%. They also exhibited efficient drug release performance in a simulated body fluid environment. Cell endocytosis experiments demonstrated that DF-TAPB-COF and DF-TATB-COF could be effectively endocytosed by cells. Hence, this study offers new insight into the design and development of COF-based drug carrier systems.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
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| Enthalten in: |
RSC advances - 12(2022), 48 vom: 27. Okt., Seite 31276-31281 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ma, Baiwei [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Revised 10.11.2022 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1039/d2ra05534a |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM348627645 |
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| 520 | |a This journal is © The Royal Society of Chemistry. | ||
| 520 | |a In this study, two novel fluorine-functionalized crystalline covalent organic frameworks (COFs), namely DF-TAPB-COF and DF-TATB-COF, were synthesized, and their ordered structure, porosity, suitable pore size, and abundant fluorine groups were expected to serve as effective carriers in drug delivery. The excellent cell viability of DF-TAPB-COF and DF-TATB-COF was verified using MTT assays. Both COFs exhibited very high loading capacities in terms of drug loading performance, in particular the drug loading rate of DF-TAPB-COF for 5-fluorouracil (5-FU) was up to 69%. They also exhibited efficient drug release performance in a simulated body fluid environment. Cell endocytosis experiments demonstrated that DF-TAPB-COF and DF-TATB-COF could be effectively endocytosed by cells. Hence, this study offers new insight into the design and development of COF-based drug carrier systems | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Xu, Yimeng |e verfasserin |4 aut | |
| 700 | 1 | |a Hu, Fujia |e verfasserin |4 aut | |
| 700 | 1 | |a Zhai, Lipeng |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Yongyu |e verfasserin |4 aut | |
| 700 | 1 | |a Qiao, Huijie |e verfasserin |4 aut | |
| 700 | 1 | |a Xiong, Jiabin |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Dehong |e verfasserin |4 aut | |
| 700 | 1 | |a Ni, Zhihui |e verfasserin |4 aut | |
| 700 | 1 | |a Zheng, Xiaofei |e verfasserin |4 aut | |
| 700 | 1 | |a Mi, Liwei |e verfasserin |4 aut | |
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