Adipose-Derived Stromal Cell-Based Therapies for Radiation-Induced Fibrosis
Significance: Half of all cancer patients receive radiation therapy as a component of their treatment regimen, and the most common resulting complication is radiation-induced fibrosis (RIF) of the skin and soft tissue. This thickening of the dermis paired with decreased vascularity results in functional limitations and esthetic concerns and poses unique challenges when considering surgical exploration or reconstruction. Existing therapeutic options for RIF of the skin are limited both in scope and efficacy. Cell-based therapies have emerged as a promising means of utilizing regenerative cell populations to improve both functional and esthetic outcomes, and even as prophylaxis for RIF. Recent Advances: As one of the leading areas of cell-based therapy research, adipose-derived stromal cells (ADSCs) demonstrate significant therapeutic potential in the treatment of RIF. The introduction of the ADSC-augmented fat graft has shown clinical utility. Recent research dedicated to characterizing specific ADSC subpopulations points toward further granularity in understanding of the mechanisms driving the well-established clinical outcomes seen with fat grafting therapy. Critical Issues: Various animal models of RIF demonstrated improved clinical outcomes following treatment with cell-based therapies, but the cellular and molecular basis underlying these effects remains poorly understood. Future Directions: Recent literature has focused on improving the efficacy of cell-based therapies, most notably through (1) augmentation of fat grafts with platelet-rich plasma and (2) the modification of expressed RNA through epitranscriptomics. For the latter, new and promising gene targets continue to be identified which have the potential to reverse the effects of fibrosis by increasing angiogenesis, decreasing inflammation, and promoting adipogenesis.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2022 |
|---|---|
| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2022 |
|---|---|
| Enthalten in: |
Advances in wound care - (2022) vom: 09. Dez. |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Berry, Charlotte E [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Adipose-derived stromal cells |
|---|
| Anmerkungen: |
Date Revised 16.02.2024 published: Print-Electronic Citation Status Publisher |
|---|
| doi: |
10.1089/wound.2022.0103 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM348589883 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM348589883 | ||
| 003 | DE-627 | ||
| 005 | 20240216232245.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1089/wound.2022.0103 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1295.xml |
| 035 | |a (DE-627)NLM348589883 | ||
| 035 | |a (NLM)36345216 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Berry, Charlotte E |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Adipose-Derived Stromal Cell-Based Therapies for Radiation-Induced Fibrosis |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 16.02.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a Significance: Half of all cancer patients receive radiation therapy as a component of their treatment regimen, and the most common resulting complication is radiation-induced fibrosis (RIF) of the skin and soft tissue. This thickening of the dermis paired with decreased vascularity results in functional limitations and esthetic concerns and poses unique challenges when considering surgical exploration or reconstruction. Existing therapeutic options for RIF of the skin are limited both in scope and efficacy. Cell-based therapies have emerged as a promising means of utilizing regenerative cell populations to improve both functional and esthetic outcomes, and even as prophylaxis for RIF. Recent Advances: As one of the leading areas of cell-based therapy research, adipose-derived stromal cells (ADSCs) demonstrate significant therapeutic potential in the treatment of RIF. The introduction of the ADSC-augmented fat graft has shown clinical utility. Recent research dedicated to characterizing specific ADSC subpopulations points toward further granularity in understanding of the mechanisms driving the well-established clinical outcomes seen with fat grafting therapy. Critical Issues: Various animal models of RIF demonstrated improved clinical outcomes following treatment with cell-based therapies, but the cellular and molecular basis underlying these effects remains poorly understood. Future Directions: Recent literature has focused on improving the efficacy of cell-based therapies, most notably through (1) augmentation of fat grafts with platelet-rich plasma and (2) the modification of expressed RNA through epitranscriptomics. For the latter, new and promising gene targets continue to be identified which have the potential to reverse the effects of fibrosis by increasing angiogenesis, decreasing inflammation, and promoting adipogenesis | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a adipose-derived stromal cells | |
| 650 | 4 | |a cell assisted lipotransfer | |
| 650 | 4 | |a fibrosis | |
| 650 | 4 | |a radiation | |
| 650 | 4 | |a review | |
| 700 | 1 | |a Abbas, Darren B |e verfasserin |4 aut | |
| 700 | 1 | |a Lintel, Hendrik A |e verfasserin |4 aut | |
| 700 | 1 | |a Churukian, Andrew A |e verfasserin |4 aut | |
| 700 | 1 | |a Griffin, Michelle |e verfasserin |4 aut | |
| 700 | 1 | |a Guo, Jason L |e verfasserin |4 aut | |
| 700 | 1 | |a Cotterell, Asha C |e verfasserin |4 aut | |
| 700 | 1 | |a Parker, Jennifer B Laufey |e verfasserin |4 aut | |
| 700 | 1 | |a Downer, Mauricio A |e verfasserin |4 aut | |
| 700 | 1 | |a Longaker, Michael T |e verfasserin |4 aut | |
| 700 | 1 | |a Wan, Derrick C |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Advances in wound care |d 2012 |g (2022) vom: 09. Dez. |w (DE-627)NLM235445002 |x 2162-1918 |7 nnns |
| 773 | 1 | 8 | |g year:2022 |g day:09 |g month:12 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1089/wound.2022.0103 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |j 2022 |b 09 |c 12 | ||