Humoral immunity after second dose of BNT162b2 vaccine in Japanese communities : an observational cross-sectional study, Fukushima Vaccination Community Survey
© 2022. The Author(s)..
To reveal waning humoral immunity after second dose BNT162b2 vaccinations in a rural Japanese community and determine factors affecting antibody titers. We aimed to report Immunoglobulin G (IgG) antibody against the SARS-CoV-2 spike (S1) protein levels and neutralizing activity in a large scale community based cohort.
METHODS: Participants in the observational cross-sectional study received a second dose of vaccination with BNT162b2 (Pfizer/BioNTech) and were not previously infected with COVID-19. Questionnaire-collected data on sex, age, adverse vaccine reactions, and medical history was obtained.
RESULTS: Data from 2496 participants revealed that older age groups reached a low antibody titer 90-120 days after the second vaccination. Neutralizing activity decreased with age; 35 (13.3%) of those aged ≥ 80 years had neutralizing activity under the cut-off value. Neutralizing activity > 179 days from the second vaccination was 11.6% compared to that at < 60 days from the second vaccination. Significantly lower IgG antibody titers and neutralizing activity were associated with age, male sex, increased time from second vaccination, smoking, steroids, immunosuppression, and comorbidities.
CONCLUSIONS: Antibody titer decreased substantially over time. Susceptible populations, older people, men, smokers, steroid users, immunosuppression users, and people with three or more comorbidities may require a special protection strategy.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
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| Enthalten in: |
Scientific reports - 12(2022), 1 vom: 07. Nov., Seite 18929 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kobashi, Yurie [VerfasserIn] |
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| Links: |
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| Themen: |
Antibodies, Neutralizing |
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| Anmerkungen: |
Date Completed 09.11.2022 Date Revised 05.01.2023 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1038/s41598-022-21797-x |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM34858380X |
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| 245 | 1 | 0 | |a Humoral immunity after second dose of BNT162b2 vaccine in Japanese communities |b an observational cross-sectional study, Fukushima Vaccination Community Survey |
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| 500 | |a Date Revised 05.01.2023 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2022. The Author(s). | ||
| 520 | |a To reveal waning humoral immunity after second dose BNT162b2 vaccinations in a rural Japanese community and determine factors affecting antibody titers. We aimed to report Immunoglobulin G (IgG) antibody against the SARS-CoV-2 spike (S1) protein levels and neutralizing activity in a large scale community based cohort | ||
| 520 | |a METHODS: Participants in the observational cross-sectional study received a second dose of vaccination with BNT162b2 (Pfizer/BioNTech) and were not previously infected with COVID-19. Questionnaire-collected data on sex, age, adverse vaccine reactions, and medical history was obtained | ||
| 520 | |a RESULTS: Data from 2496 participants revealed that older age groups reached a low antibody titer 90-120 days after the second vaccination. Neutralizing activity decreased with age; 35 (13.3%) of those aged ≥ 80 years had neutralizing activity under the cut-off value. Neutralizing activity > 179 days from the second vaccination was 11.6% compared to that at < 60 days from the second vaccination. Significantly lower IgG antibody titers and neutralizing activity were associated with age, male sex, increased time from second vaccination, smoking, steroids, immunosuppression, and comorbidities | ||
| 520 | |a CONCLUSIONS: Antibody titer decreased substantially over time. Susceptible populations, older people, men, smokers, steroid users, immunosuppression users, and people with three or more comorbidities may require a special protection strategy | ||
| 650 | 4 | |a Observational Study | |
| 650 | 4 | |a Journal Article | |
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| 650 | 7 | |a Antibodies, Viral |2 NLM | |
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| 650 | 7 | |a Antibodies, Neutralizing |2 NLM | |
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| 700 | 1 | |a Sugiyama, Akira |e verfasserin |4 aut | |
| 700 | 1 | |a Nakayama, Aya |e verfasserin |4 aut | |
| 700 | 1 | |a Kaneko, Yudai |e verfasserin |4 aut | |
| 700 | 1 | |a Nishikawa, Yoshitaka |e verfasserin |4 aut | |
| 700 | 1 | |a Omata, Fumiya |e verfasserin |4 aut | |
| 700 | 1 | |a Takita, Morihito |e verfasserin |4 aut | |
| 700 | 1 | |a Yamamoto, Chika |e verfasserin |4 aut | |
| 700 | 1 | |a Yoshida, Makoto |e verfasserin |4 aut | |
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| 700 | 1 | |a Tsubokura, Masaharu |e verfasserin |4 aut | |
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