Mitochondrial haplogroups and cognitive progression in Parkinson's disease
© The Author(s) 2022. Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For permissions, please e-mail: journals.permissionsoup.com..
Mitochondria are a culprit in the onset of Parkinson's disease, but their role during disease progression is unclear. Here we used Cox proportional hazards models to exam the effect of variation in the mitochondrial genome on longitudinal cognitive and motor progression over time in 4064 patients with Parkinson's disease. Mitochondrial macro-haplogroup was associated with reduced risk of cognitive disease progression in the discovery and replication population. In the combined analysis, patients with the super macro-haplogroup J, T, U# had a 41% lower risk of cognitive progression with P = 2.42 × 10-6 compared to those with macro-haplogroup H. Exploratory analysis indicated that the common mitochondrial DNA variant, m.2706A>G, was associated with slower cognitive decline with a hazard ratio of 0.68 (95% confidence interval 0.56-0.81) and P = 2.46 × 10-5. Mitochondrial haplogroups were not appreciably linked to motor progression. This initial genetic survival study of the mitochondrial genome suggests that mitochondrial haplogroups may be associated with the pace of cognitive progression in Parkinson's disease over time.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:146 |
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| Enthalten in: |
Brain : a journal of neurology - 146(2023), 1 vom: 05. Jan., Seite 42-49 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Liu, Ganqiang [VerfasserIn] |
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| Links: |
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| Themen: |
Cognitive progression |
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| Anmerkungen: |
Date Completed 10.01.2023 Date Revised 14.02.2024 published: Print Citation Status MEDLINE |
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| doi: |
10.1093/brain/awac327 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM348574606 |
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| 100 | 1 | |a Liu, Ganqiang |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Mitochondrial haplogroups and cognitive progression in Parkinson's disease |
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| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © The Author(s) 2022. Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For permissions, please e-mail: journals.permissionsoup.com. | ||
| 520 | |a Mitochondria are a culprit in the onset of Parkinson's disease, but their role during disease progression is unclear. Here we used Cox proportional hazards models to exam the effect of variation in the mitochondrial genome on longitudinal cognitive and motor progression over time in 4064 patients with Parkinson's disease. Mitochondrial macro-haplogroup was associated with reduced risk of cognitive disease progression in the discovery and replication population. In the combined analysis, patients with the super macro-haplogroup J, T, U# had a 41% lower risk of cognitive progression with P = 2.42 × 10-6 compared to those with macro-haplogroup H. Exploratory analysis indicated that the common mitochondrial DNA variant, m.2706A>G, was associated with slower cognitive decline with a hazard ratio of 0.68 (95% confidence interval 0.56-0.81) and P = 2.46 × 10-5. Mitochondrial haplogroups were not appreciably linked to motor progression. This initial genetic survival study of the mitochondrial genome suggests that mitochondrial haplogroups may be associated with the pace of cognitive progression in Parkinson's disease over time | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Parkinson’s disease | |
| 650 | 4 | |a cognitive progression | |
| 650 | 4 | |a mitochondrial haplogroups | |
| 650 | 7 | |a DNA, Mitochondrial |2 NLM | |
| 700 | 1 | |a Ni, Chunming |e verfasserin |4 aut | |
| 700 | 1 | |a Zhan, Jiamin |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Weimin |e verfasserin |4 aut | |
| 700 | 1 | |a Luo, Junfeng |e verfasserin |4 aut | |
| 700 | 1 | |a Liao, Zhixiang |e verfasserin |4 aut | |
| 700 | 1 | |a Locascio, Joseph J |e verfasserin |4 aut | |
| 700 | 1 | |a Xian, Wenbiao |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Ling |e verfasserin |4 aut | |
| 700 | 1 | |a Pei, Zhong |e verfasserin |4 aut | |
| 700 | 1 | |a Corvol, Jean-Christophe |e verfasserin |4 aut | |
| 700 | 1 | |a Maple-Grødem, Jodi |e verfasserin |4 aut | |
| 700 | 1 | |a Campbell, Meghan C |e verfasserin |4 aut | |
| 700 | 1 | |a Elbaz, Alexis |e verfasserin |4 aut | |
| 700 | 1 | |a Lesage, Suzanne |e verfasserin |4 aut | |
| 700 | 1 | |a Brice, Alexis |e verfasserin |4 aut | |
| 700 | 1 | |a Hung, Albert Y |e verfasserin |4 aut | |
| 700 | 1 | |a Schwarzschild, Michael A |e verfasserin |4 aut | |
| 700 | 1 | |a Hayes, Michael T |e verfasserin |4 aut | |
| 700 | 1 | |a Wills, Anne-Marie |e verfasserin |4 aut | |
| 700 | 1 | |a Ravina, Bernard |e verfasserin |4 aut | |
| 700 | 1 | |a Shoulson, Ira |e verfasserin |4 aut | |
| 700 | 1 | |a Taba, Pille |e verfasserin |4 aut | |
| 700 | 1 | |a Kõks, Sulev |e verfasserin |4 aut | |
| 700 | 1 | |a Beach, Thomas G |e verfasserin |4 aut | |
| 700 | 1 | |a Cormier-Dequaire, Florence |e verfasserin |4 aut | |
| 700 | 1 | |a Alves, Guido |e verfasserin |4 aut | |
| 700 | 1 | |a Tysnes, Ole-Bjørn |e verfasserin |4 aut | |
| 700 | 1 | |a Perlmutter, Joel S |e verfasserin |4 aut | |
| 700 | 1 | |a Heutink, Peter |e verfasserin |4 aut | |
| 700 | 1 | |a van Hilten, Jacobus J |e verfasserin |4 aut | |
| 700 | 1 | |a Barker, Roger A |e verfasserin |4 aut | |
| 700 | 1 | |a Williams-Gray, Caroline H |e verfasserin |4 aut | |
| 700 | 1 | |a Scherzer, Clemens R |e verfasserin |4 aut | |
| 700 | 0 | |a International Genetics of Parkinson Disease Progression (IGPP) Consortium |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Ganqiang |e investigator |4 oth | |
| 700 | 1 | |a Valentino, Rebecca R |e investigator |4 oth | |
| 700 | 1 | |a Peng, Jiajie |e investigator |4 oth | |
| 700 | 1 | |a Liao, Zhixiang |e investigator |4 oth | |
| 700 | 1 | |a Locascio, Joseph J |e investigator |4 oth | |
| 700 | 1 | |a Corvol, Jean-Christophe |e investigator |4 oth | |
| 700 | 1 | |a Dong, Xianjun |e investigator |4 oth | |
| 700 | 1 | |a Maple-Grødem, Jodi |e investigator |4 oth | |
| 700 | 1 | |a Campbell, Meghan C |e investigator |4 oth | |
| 700 | 1 | |a Elbaz, Alexis |e investigator |4 oth | |
| 700 | 1 | |a Lesage, Suzanne |e investigator |4 oth | |
| 700 | 1 | |a Brice, Alexis |e investigator |4 oth | |
| 700 | 1 | |a Mangone, Graziella |e investigator |4 oth | |
| 700 | 1 | |a Growdon, John H |e investigator |4 oth | |
| 700 | 1 | |a Hung, Albert Y |e investigator |4 oth | |
| 700 | 1 | |a Schwarzchild, Michael A |e investigator |4 oth | |
| 700 | 1 | |a Hayes, Michael T |e investigator |4 oth | |
| 700 | 1 | |a Wills, Anne-Marie |e investigator |4 oth | |
| 700 | 1 | |a Herrington, Todd M |e investigator |4 oth | |
| 700 | 1 | |a Ravian, Bernard |e investigator |4 oth | |
| 700 | 1 | |a Shoulson, Ira |e investigator |4 oth | |
| 700 | 1 | |a Taba, Pille |e investigator |4 oth | |
| 700 | 1 | |a Kõks, Sulev |e investigator |4 oth | |
| 700 | 1 | |a Beach, Thomas G |e investigator |4 oth | |
| 700 | 1 | |a Cormier-Dequaire, Florence |e investigator |4 oth | |
| 700 | 1 | |a Alves, Guido |e investigator |4 oth | |
| 700 | 1 | |a Tysnes, Ole-Bjørn |e investigator |4 oth | |
| 700 | 1 | |a Perlmutter, Joel S |e investigator |4 oth | |
| 700 | 1 | |a Heutink, Peter |e investigator |4 oth | |
| 700 | 1 | |a van Hilten, Jacobus J |e investigator |4 oth | |
| 700 | 1 | |a Kasten, Meike |e investigator |4 oth | |
| 700 | 1 | |a Mollenhauer, Brit |e investigator |4 oth | |
| 700 | 1 | |a Trenkwalder, Claudia |e investigator |4 oth | |
| 700 | 1 | |a Klein, Christine |e investigator |4 oth | |
| 700 | 1 | |a Barker, Roger A |e investigator |4 oth | |
| 700 | 1 | |a Williams-Gray, Caroline H |e investigator |4 oth | |
| 700 | 1 | |a Marinus, Johan |e investigator |4 oth | |
| 700 | 1 | |a Scherzer, Clemens R |e investigator |4 oth | |
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