An Alternative Autophagy-Related Mechanism of Chloroquine Drug Resistance in the Malaria Parasite
We generated highly chloroquine (CQ)-resistant (ResCQ) Plasmodium yoelii parasites by stepwise exposure to increasing concentrations of CQ and CQ-sensitive parasites (SenCQ) by parallel mock treatments. No mutations in genes that are associated with drug resistance were detected in ResCQ clones. Autophagy-related genes were highly upregulated in SenCQ compared to ResCQ parasites during CQ treatment. This indicates that CQ resistance can be developed in the malaria parasite by the inhibition of autophagy as an alternative drug resistance mechanism.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:66 |
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| Enthalten in: |
Antimicrobial agents and chemotherapy - 66(2022), 12 vom: 20. Dez., Seite e0026922 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kamil, Mohd [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 30.12.2022 Date Revised 08.05.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1128/aac.00269-22 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM348560168 |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a We generated highly chloroquine (CQ)-resistant (ResCQ) Plasmodium yoelii parasites by stepwise exposure to increasing concentrations of CQ and CQ-sensitive parasites (SenCQ) by parallel mock treatments. No mutations in genes that are associated with drug resistance were detected in ResCQ clones. Autophagy-related genes were highly upregulated in SenCQ compared to ResCQ parasites during CQ treatment. This indicates that CQ resistance can be developed in the malaria parasite by the inhibition of autophagy as an alternative drug resistance mechanism | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Plasmodium yoelii | |
| 650 | 4 | |a autophagy | |
| 650 | 4 | |a chloroquine | |
| 650 | 4 | |a drug resistance | |
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| 650 | 7 | |a Protozoan Proteins |2 NLM | |
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| 700 | 1 | |a Burak, Pinar |e verfasserin |4 aut | |
| 700 | 1 | |a Deveci, Gozde |e verfasserin |4 aut | |
| 700 | 1 | |a Yilmaz, Ilknur |e verfasserin |4 aut | |
| 700 | 1 | |a Aly, Ahmed S I |e verfasserin |4 aut | |
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