Effectiveness of exhaled nitric oxide for the prediction of non-invasive left atrial pressure in older people : a cross-sectional cohort study
Copyright © 2022, The Authors..
BACKGROUND: During left-sided heart failure (HF), left atrial and pulmonary venous pressure increase, which may lead to pulmonary congestion. Previous cohort studies, examining participants with symptomatic HF or rheumatic heart disease, suggest a relationship between increased left atrial pressure (LAP) and fractional exhaled nitric oxide (FeNO).
AIM: To examine the strength of association between FeNO and echocardiographic assessment of LAP by the E/e' ratio, to determine if FeNO could be used to identify those with elevated LAP.
DESIGN & SETTING: This cross-sectional cohort study examined a subset of the OxVALVE cohort aged ≥65 years. Data collection was undertaken in primary care practices in central England.
METHOD: Each participant underwent a focused cardiovascular history and clinical examination. Standard transthoracic echocardiographic (TTE) assessment was performed on all participants, with the E/e' ratio calculated to obtain a validated surrogate of LAP. FeNO was measured in 227 participants.
RESULTS: FeNO was higher in males compared with females and no different in participants with asthma, chronic obstructive pulmonary disease (COPD), or those using inhaled steroids. Participants with a high E/e' (>14) were older, with a higher proportion of females than males. There was no relationship between E/e' and FeNO, either when measured as a continuous variable or in the group with high E/e'.
CONCLUSION: FeNO was not found to be an accurate predictor of elevated LAP in a primary care setting.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:7 |
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| Enthalten in: |
BJGP open - 7(2023), 1 vom: 01. März |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Jones, Samuel Thomas [VerfasserIn] |
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| Links: |
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| Themen: |
Cardiology |
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| Anmerkungen: |
Date Revised 21.07.2023 published: Electronic-Print Citation Status PubMed-not-MEDLINE |
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| doi: |
10.3399/BJGPO.2022.0105 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM348467877 |
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| 100 | 1 | |a Jones, Samuel Thomas |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Effectiveness of exhaled nitric oxide for the prediction of non-invasive left atrial pressure in older people |b a cross-sectional cohort study |
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| 500 | |a Date Revised 21.07.2023 | ||
| 500 | |a published: Electronic-Print | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a Copyright © 2022, The Authors. | ||
| 520 | |a BACKGROUND: During left-sided heart failure (HF), left atrial and pulmonary venous pressure increase, which may lead to pulmonary congestion. Previous cohort studies, examining participants with symptomatic HF or rheumatic heart disease, suggest a relationship between increased left atrial pressure (LAP) and fractional exhaled nitric oxide (FeNO) | ||
| 520 | |a AIM: To examine the strength of association between FeNO and echocardiographic assessment of LAP by the E/e' ratio, to determine if FeNO could be used to identify those with elevated LAP | ||
| 520 | |a DESIGN & SETTING: This cross-sectional cohort study examined a subset of the OxVALVE cohort aged ≥65 years. Data collection was undertaken in primary care practices in central England | ||
| 520 | |a METHOD: Each participant underwent a focused cardiovascular history and clinical examination. Standard transthoracic echocardiographic (TTE) assessment was performed on all participants, with the E/e' ratio calculated to obtain a validated surrogate of LAP. FeNO was measured in 227 participants | ||
| 520 | |a RESULTS: FeNO was higher in males compared with females and no different in participants with asthma, chronic obstructive pulmonary disease (COPD), or those using inhaled steroids. Participants with a high E/e' (>14) were older, with a higher proportion of females than males. There was no relationship between E/e' and FeNO, either when measured as a continuous variable or in the group with high E/e' | ||
| 520 | |a CONCLUSION: FeNO was not found to be an accurate predictor of elevated LAP in a primary care setting | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a cardiology | |
| 650 | 4 | |a family practice | |
| 650 | 4 | |a general practice | |
| 650 | 4 | |a heart failure | |
| 650 | 4 | |a primary health care | |
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| 700 | 1 | |a Pavord, Ian |e verfasserin |4 aut | |
| 700 | 1 | |a Myerson, Saul G |e verfasserin |4 aut | |
| 700 | 1 | |a Prendergast, Bernard D |e verfasserin |4 aut | |
| 700 | 1 | |a Coffey, Sean |e verfasserin |4 aut | |
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