MiR-130/SNAP-25 axis regulate presynaptic alteration in anterior cingulate cortex involved in lead induced attention deficits
Copyright © 2022 Elsevier B.V. All rights reserved..
Brain volume decrease in the anterior cingulate cortex (ACC) after lead (Pb) exposure has been linked to persistent impairment of attention behavior. However, the precise structural change and molecular mechanism for the Pb-induced ACC alteration and its contribution to inattention have yet to be fully characterized. The present study determined the role of miRNA regulated synaptic structural and functional impairment in the ACC and its relationship to attention deficit disorder in Pb exposed mice. Results showed that Pb exposure induced presynaptic impairment and structural alterations in the ACC. Furthermore, we screened for critical miRNA targets responsible for the synaptic alteration. We found that miR-130, which regulates presynaptic vesicle releasing protein SNAP-25, was responsible for the presynaptic impairment in the ACC and attention deficits in mice. Blocking miR-130 function reversed the Pb-induced decrease in the expression of its presynaptic target SNAP-25, leading to the redistribution of presynaptic vesicles, as well as improved presynaptic function and attention in Pb exposed mice. We report, for the first time, that miR-130 regulating SNAP-25 mediates Pb-induced presynaptic structural and functional impairment in the ACC along with attention deficit disorder in mice.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:443 |
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| Enthalten in: |
Journal of hazardous materials - 443(2023), Pt B vom: 05. Feb., Seite 130249 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wang, Tao [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 01.12.2022 Date Revised 01.12.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.jhazmat.2022.130249 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM348461577 |
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| 100 | 1 | |a Wang, Tao |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a MiR-130/SNAP-25 axis regulate presynaptic alteration in anterior cingulate cortex involved in lead induced attention deficits |
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| 500 | |a Date Revised 01.12.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2022 Elsevier B.V. All rights reserved. | ||
| 520 | |a Brain volume decrease in the anterior cingulate cortex (ACC) after lead (Pb) exposure has been linked to persistent impairment of attention behavior. However, the precise structural change and molecular mechanism for the Pb-induced ACC alteration and its contribution to inattention have yet to be fully characterized. The present study determined the role of miRNA regulated synaptic structural and functional impairment in the ACC and its relationship to attention deficit disorder in Pb exposed mice. Results showed that Pb exposure induced presynaptic impairment and structural alterations in the ACC. Furthermore, we screened for critical miRNA targets responsible for the synaptic alteration. We found that miR-130, which regulates presynaptic vesicle releasing protein SNAP-25, was responsible for the presynaptic impairment in the ACC and attention deficits in mice. Blocking miR-130 function reversed the Pb-induced decrease in the expression of its presynaptic target SNAP-25, leading to the redistribution of presynaptic vesicles, as well as improved presynaptic function and attention in Pb exposed mice. We report, for the first time, that miR-130 regulating SNAP-25 mediates Pb-induced presynaptic structural and functional impairment in the ACC along with attention deficit disorder in mice | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Anterior cingulate cortex | |
| 650 | 4 | |a Attention deficit | |
| 650 | 4 | |a Lead (Pb) | |
| 650 | 4 | |a Presynaptic function impairment | |
| 650 | 7 | |a Lead |2 NLM | |
| 650 | 7 | |a 2P299V784P |2 NLM | |
| 650 | 7 | |a MicroRNAs |2 NLM | |
| 650 | 7 | |a Snap25 protein, mouse |2 NLM | |
| 700 | 1 | |a Guan, Rui-Li |e verfasserin |4 aut | |
| 700 | 1 | |a Zou, Yun-Feng |e verfasserin |4 aut | |
| 700 | 1 | |a Zheng, Gang |e verfasserin |4 aut | |
| 700 | 1 | |a Shen, Xue-Feng |e verfasserin |4 aut | |
| 700 | 1 | |a Cao, Zi-Peng |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Rui-Hua |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Ming-Chao |e verfasserin |4 aut | |
| 700 | 1 | |a Du, Ke-Jun |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Xue-Hang |e verfasserin |4 aut | |
| 700 | 1 | |a Aschner, Michael |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, Ming-Gao |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Jing Yuan |e verfasserin |4 aut | |
| 700 | 1 | |a Luo, Wen-Jing |e verfasserin |4 aut | |
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