Predictors of Poor Outcomes in Young Non-Comorbid Patients with COVID-19
Copyright: © 2022 Permanyer..
Background: Prognostic factors in previously healthy young patients with COVID-19 remained understudied.
Objectives: The objective of the study was to identify factors associated with in-hospital death or need for invasive mechanical ventilation (IMV) in young (aged ≤ 65 years) and previously healthy patients with COVID-19.
Methods: We conducted a prospective cohort study that included patients admitted with COVID-19. The primary outcome was in-hospital death/need for IMV. Secondary outcomes included need for IMV during follow-up, days on IMV, length of stay (LOS), hospital-acquired pneumonia/ventilator-associated pneumonia (HAP/VAP), and pulmonary embolism (PE). Bivariate and multivariate analyses were performed.
Results: Among 92 patients, primary outcome occurred in 16 (17%), death in 12 (13%), need for IMV in 16 (17%), HAP/VAP in 7 (8%), and PE in 2 (2%). Median LOS and IMV duration were 7 and 12 days, respectively. Independent associations were found between the primary outcome and male sex (Adjusted odds ratio [aOR] 7.1, 95%CI 1.1-46.0, p < 0.05), D-dimer levels > 1000ng/mL (aOR 9.0, 95%CI 1.6-49.1, p < 0.05), and RT-PCR Ct-value ≤ 24 on initial swab samples (aOR 14.3, 95%CI 2.0-101.5, p < 0.01).
Conclusions: In young and non-comorbid COVID-19 patients, male sex, higher levels of D-dimer, and low SARS-CoV-2 RT-PCR Ct-value on an initial nasopharyngeal swab were independently associated with increased in-hospital mortality or need for IMV. (Rev Invest Clin. 2022;74(5):268-75).
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:74 |
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| Enthalten in: |
Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion - 74(2022), 5 vom: 03., Seite 268-275 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Martínez-Guerra, Bernardo A [VerfasserIn] |
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| Links: |
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| Themen: |
COVID-19 |
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| Anmerkungen: |
Date Completed 07.11.2022 Date Revised 07.11.2022 published: Print Citation Status MEDLINE |
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| doi: |
10.24875/RIC.22000162 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM348419333 |
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| 100 | 1 | |a Martínez-Guerra, Bernardo A |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Predictors of Poor Outcomes in Young Non-Comorbid Patients with COVID-19 |
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| 500 | |a Date Revised 07.11.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright: © 2022 Permanyer. | ||
| 520 | |a Background: Prognostic factors in previously healthy young patients with COVID-19 remained understudied | ||
| 520 | |a Objectives: The objective of the study was to identify factors associated with in-hospital death or need for invasive mechanical ventilation (IMV) in young (aged ≤ 65 years) and previously healthy patients with COVID-19 | ||
| 520 | |a Methods: We conducted a prospective cohort study that included patients admitted with COVID-19. The primary outcome was in-hospital death/need for IMV. Secondary outcomes included need for IMV during follow-up, days on IMV, length of stay (LOS), hospital-acquired pneumonia/ventilator-associated pneumonia (HAP/VAP), and pulmonary embolism (PE). Bivariate and multivariate analyses were performed | ||
| 520 | |a Results: Among 92 patients, primary outcome occurred in 16 (17%), death in 12 (13%), need for IMV in 16 (17%), HAP/VAP in 7 (8%), and PE in 2 (2%). Median LOS and IMV duration were 7 and 12 days, respectively. Independent associations were found between the primary outcome and male sex (Adjusted odds ratio [aOR] 7.1, 95%CI 1.1-46.0, p < 0.05), D-dimer levels > 1000ng/mL (aOR 9.0, 95%CI 1.6-49.1, p < 0.05), and RT-PCR Ct-value ≤ 24 on initial swab samples (aOR 14.3, 95%CI 2.0-101.5, p < 0.01) | ||
| 520 | |a Conclusions: In young and non-comorbid COVID-19 patients, male sex, higher levels of D-dimer, and low SARS-CoV-2 RT-PCR Ct-value on an initial nasopharyngeal swab were independently associated with increased in-hospital mortality or need for IMV. (Rev Invest Clin. 2022;74(5):268-75) | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a COVID-19 | |
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| 650 | 4 | |a Polymerase chain reaction | |
| 650 | 4 | |a SARS-CoV-2 | |
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| 700 | 1 | |a Medrano-Borromeo, Carla |e verfasserin |4 aut | |
| 700 | 1 | |a González-Lara, María F |e verfasserin |4 aut | |
| 700 | 1 | |a Román-Montes, Carla M |e verfasserin |4 aut | |
| 700 | 1 | |a Tamez-Torres, Karla M |e verfasserin |4 aut | |
| 700 | 1 | |a Rajme-López, Sandra |e verfasserin |4 aut | |
| 700 | 1 | |a Salgado-Guízar, Karla D |e verfasserin |4 aut | |
| 700 | 1 | |a Juárez-Menéndez, Noe A |e verfasserin |4 aut | |
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| 700 | 1 | |a Ruiz-Palacios, Guillermo M |e verfasserin |4 aut | |
| 700 | 1 | |a Ponce-de-León, Alfredo |e verfasserin |4 aut | |
| 700 | 1 | |a Sifuentes-Osornio, José |e verfasserin |4 aut | |
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