Cartography of SARS-CoV-2 variants based on the susceptibility to therapeutic monoclonal antibodies
© 2022 Wiley Periodicals LLC..
A comprehensive picture of a phenotypic relationship among severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants has been poorly studied. Here, this study presents cartography showing how the wild-type strain of SARS-CoV-2 and 14 variants are alike or different from the perspective of the susceptibility to 12 therapeutic monoclonal antibodies. The Alpha variant is close to the wild-type strain, whereas the Beta, Gamma, and Delta variants diverge from the wild-type. The map highlights the very unique property of the Omicron variant. Interestingly, sublineages of the Omicron variants, BA.1, BA.2, and BA.4/5, differ substantially in the cartography.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:95 |
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| Enthalten in: |
Journal of medical virology - 95(2023), 1 vom: 23. Jan., Seite e28275 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Furuse, Yuki [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 10.01.2023 Date Revised 09.02.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/jmv.28275 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM348400225 |
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| 520 | |a A comprehensive picture of a phenotypic relationship among severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants has been poorly studied. Here, this study presents cartography showing how the wild-type strain of SARS-CoV-2 and 14 variants are alike or different from the perspective of the susceptibility to 12 therapeutic monoclonal antibodies. The Alpha variant is close to the wild-type strain, whereas the Beta, Gamma, and Delta variants diverge from the wild-type. The map highlights the very unique property of the Omicron variant. Interestingly, sublineages of the Omicron variants, BA.1, BA.2, and BA.4/5, differ substantially in the cartography | ||
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