Health-related quality of life among persons with initial mild, moderate, and severe or critical COVID-19 at 1 and 12 months after infection : a prospective cohort study
© 2022. The Author(s)..
BACKGROUND: Currently, there is limited evidence about the long-term impact on physical, social and emotional functioning, i.e. health-related quality of life (HRQL) after mild or moderate COVID-19 not requiring hospitalization. We compared HRQL among persons with initial mild, moderate or severe/critical COVID-19 at 1 and 12 months following illness onset with Dutch population norms and investigated the impact of restrictive public health control measures on HRQL.
METHODS: RECoVERED, a prospective cohort study in Amsterdam, the Netherlands, enrolled adult participants after confirmed SARS-CoV-2 diagnosis. HRQL was assessed with the Medical Outcomes Study Short Form 36-item health survey (SF-36). SF-36 scores were converted to standard scores based on an age- and sex-matched representative reference sample of the Dutch population. Differences in HRQL over time were compared among persons with initial mild, moderate or severe/critical COVID-19 using mixed linear models adjusted for potential confounders.
RESULTS: By December 2021, 349 persons were enrolled of whom 269 completed at least one SF-36 form (77%). One month after illness onset, HRQL was significantly below population norms on all SF-36 domains except general health and bodily pain among persons with mild COVID-19. After 12 months, persons with mild COVID-19 had HRQL within population norms, whereas persons with moderate or severe/critical COVID-19 had HRQL below population norms on more than half of the SF-36 domains. Dutch-origin participants had significantly better HRQL than participants with a migration background. Participants with three or more COVID-19 high-risk comorbidities had worse HRQL than part participants with fewer comorbidities. Participants who completed the SF-36 when restrictive public health control measures applied reported less limitations in social and physical functioning and less impaired mental health than participants who completed the SF-36 when no restrictive measures applied.
CONCLUSIONS: Twelve months after illness onset, persons with initial mild COVID-19 had HRQL within population norms, whereas persons with initial moderate or severe/critical COVID-19 still had impaired HRQL. Having a migration background and a higher number of COVID-19 high-risk comorbidities were associated with worse HRQL. Interestingly, HRQL was less impaired during periods when restrictive public health control measures were in place compared to periods without.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:20 |
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| Enthalten in: |
BMC medicine - 20(2022), 1 vom: 02. Nov., Seite 422 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Verveen, Anouk [VerfasserIn] |
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| Links: |
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| Themen: |
COVID-19 |
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| Anmerkungen: |
Date Completed 04.11.2022 Date Revised 08.11.2022 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1186/s12916-022-02615-7 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM348381352 |
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| 100 | 1 | |a Verveen, Anouk |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Health-related quality of life among persons with initial mild, moderate, and severe or critical COVID-19 at 1 and 12 months after infection |b a prospective cohort study |
| 264 | 1 | |c 2022 | |
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| 500 | |a Date Completed 04.11.2022 | ||
| 500 | |a Date Revised 08.11.2022 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2022. The Author(s). | ||
| 520 | |a BACKGROUND: Currently, there is limited evidence about the long-term impact on physical, social and emotional functioning, i.e. health-related quality of life (HRQL) after mild or moderate COVID-19 not requiring hospitalization. We compared HRQL among persons with initial mild, moderate or severe/critical COVID-19 at 1 and 12 months following illness onset with Dutch population norms and investigated the impact of restrictive public health control measures on HRQL | ||
| 520 | |a METHODS: RECoVERED, a prospective cohort study in Amsterdam, the Netherlands, enrolled adult participants after confirmed SARS-CoV-2 diagnosis. HRQL was assessed with the Medical Outcomes Study Short Form 36-item health survey (SF-36). SF-36 scores were converted to standard scores based on an age- and sex-matched representative reference sample of the Dutch population. Differences in HRQL over time were compared among persons with initial mild, moderate or severe/critical COVID-19 using mixed linear models adjusted for potential confounders | ||
| 520 | |a RESULTS: By December 2021, 349 persons were enrolled of whom 269 completed at least one SF-36 form (77%). One month after illness onset, HRQL was significantly below population norms on all SF-36 domains except general health and bodily pain among persons with mild COVID-19. After 12 months, persons with mild COVID-19 had HRQL within population norms, whereas persons with moderate or severe/critical COVID-19 had HRQL below population norms on more than half of the SF-36 domains. Dutch-origin participants had significantly better HRQL than participants with a migration background. Participants with three or more COVID-19 high-risk comorbidities had worse HRQL than part participants with fewer comorbidities. Participants who completed the SF-36 when restrictive public health control measures applied reported less limitations in social and physical functioning and less impaired mental health than participants who completed the SF-36 when no restrictive measures applied | ||
| 520 | |a CONCLUSIONS: Twelve months after illness onset, persons with initial mild COVID-19 had HRQL within population norms, whereas persons with initial moderate or severe/critical COVID-19 still had impaired HRQL. Having a migration background and a higher number of COVID-19 high-risk comorbidities were associated with worse HRQL. Interestingly, HRQL was less impaired during periods when restrictive public health control measures were in place compared to periods without | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a Health-related quality of life | |
| 650 | 4 | |a Quality of life | |
| 650 | 4 | |a SARS-CoV-2 | |
| 700 | 1 | |a Wynberg, Elke |e verfasserin |4 aut | |
| 700 | 1 | |a van Willigen, Hugo D G |e verfasserin |4 aut | |
| 700 | 1 | |a Davidovich, Udi |e verfasserin |4 aut | |
| 700 | 1 | |a Lok, Anja |e verfasserin |4 aut | |
| 700 | 1 | |a Moll van Charante, Eric P |e verfasserin |4 aut | |
| 700 | 1 | |a de Jong, Menno D |e verfasserin |4 aut | |
| 700 | 1 | |a de Bree, Godelieve |e verfasserin |4 aut | |
| 700 | 1 | |a Prins, Maria |e verfasserin |4 aut | |
| 700 | 1 | |a Knoop, Hans |e verfasserin |4 aut | |
| 700 | 1 | |a Nieuwkerk, Pythia T |e verfasserin |4 aut | |
| 700 | 0 | |a RECoVERED Study Group |e verfasserin |4 aut | |
| 700 | 1 | |a Agard, Ivette |e investigator |4 oth | |
| 700 | 1 | |a Ayal, Jane |e investigator |4 oth | |
| 700 | 1 | |a Cavdar, Floor |e investigator |4 oth | |
| 700 | 1 | |a Craanen, Marianne |e investigator |4 oth | |
| 700 | 1 | |a Deuring, Annemarieke |e investigator |4 oth | |
| 700 | 1 | |a van Dijk, Annelies |e investigator |4 oth | |
| 700 | 1 | |a Ersan, Ertan |e investigator |4 oth | |
| 700 | 1 | |a Del Grande, Laura |e investigator |4 oth | |
| 700 | 1 | |a Hartman, Joost |e investigator |4 oth | |
| 700 | 1 | |a Koedoot, Nelleke |e investigator |4 oth | |
| 700 | 1 | |a Leenstra, Tjalling |e investigator |4 oth | |
| 700 | 1 | |a Lebbink, Romy |e investigator |4 oth | |
| 700 | 1 | |a Loomans, Dominique |e investigator |4 oth | |
| 700 | 1 | |a Makowska, Agata |e investigator |4 oth | |
| 700 | 1 | |a du Maine, Tom |e investigator |4 oth | |
| 700 | 1 | |a de Man, Ilja |e investigator |4 oth | |
| 700 | 1 | |a Matser, Amy |e investigator |4 oth | |
| 700 | 1 | |a van der Meij, Lizenka |e investigator |4 oth | |
| 700 | 1 | |a van Polanen, Marleen |e investigator |4 oth | |
| 700 | 1 | |a Oud, Maria |e investigator |4 oth | |
| 700 | 1 | |a Reid, Clark |e investigator |4 oth | |
| 700 | 1 | |a Storey, Leeann |e investigator |4 oth | |
| 700 | 1 | |a van Wijk, Marc |e investigator |4 oth | |
| 700 | 1 | |a van den Aardweg, Joost |e investigator |4 oth | |
| 700 | 1 | |a van Assem, Joyce |e investigator |4 oth | |
| 700 | 1 | |a van Beek, Marijne |e investigator |4 oth | |
| 700 | 1 | |a Blankert, Thyra |e investigator |4 oth | |
| 700 | 1 | |a Dijkstra, Maartje |e investigator |4 oth | |
| 700 | 1 | |a Figaroa, Orlane |e investigator |4 oth | |
| 700 | 1 | |a Frenkel, Leah |e investigator |4 oth | |
| 700 | 1 | |a van Gils, Marit |e investigator |4 oth | |
| 700 | 1 | |a van Haga, Jelle |e investigator |4 oth | |
| 700 | 1 | |a Han, Xiaochuan Alvin |e investigator |4 oth | |
| 700 | 1 | |a Harskamp-Holwerda, Agnes |e investigator |4 oth | |
| 700 | 1 | |a Hazenberg, Mette |e investigator |4 oth | |
| 700 | 1 | |a Hidad, Soemeja |e investigator |4 oth | |
| 700 | 1 | |a de Jong, Nina |e investigator |4 oth | |
| 700 | 1 | |a Kootstra, Neeltje |e investigator |4 oth | |
| 700 | 1 | |a Kuijt, Lara |e investigator |4 oth | |
| 700 | 1 | |a Russell, Colin |e investigator |4 oth | |
| 700 | 1 | |a van der Straten, Karlijn |e investigator |4 oth | |
| 700 | 1 | |a van der Veen, Annelou |e investigator |4 oth | |
| 700 | 1 | |a Verkaik, Bas |e investigator |4 oth | |
| 700 | 1 | |a Visser, Gerben-Rienk |e investigator |4 oth | |
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