Comparative features and outcomes of major neurological complications of COVID-19
© 2022 European Academy of Neurology..
BACKGROUND AND PURPOSE: The aim of this study was to assess the neurological complications of SARS-CoV-2 infection and compare phenotypes and outcomes in infected patients with and without selected neurological manifestations.
METHODS: The data source was a registry established by the European Academy of Neurology during the first wave of the COVID-19 pandemic. Neurologists collected data on patients with COVID-19 seen as in- and outpatients and in emergency rooms in 23 European and seven non-European countries. Prospective and retrospective data included patient demographics, lifestyle habits, comorbidities, main COVID-19 complications, hospital and intensive care unit admissions, diagnostic tests, and outcome. Acute/subacute selected neurological manifestations in patients with COVID-19 were analysed, comparing individuals with and without each condition for several risk factors.
RESULTS: By July 31, 2021, 1523 patients (758 men, 756 women, and nine intersex/unknown, aged 16-101 years) were registered. Neurological manifestations were diagnosed in 1213 infected patients (79.6%). At study entry, 978 patients (64.2%) had one or more chronic general or neurological comorbidities. Predominant acute/subacute neurological manifestations were cognitive dysfunction (N = 449, 29.5%), stroke (N = 392, 25.7%), sleep-wake disturbances (N = 250, 16.4%), dysautonomia (N = 224, 14.7%), peripheral neuropathy (N = 145, 9.5%), movement disorders (N = 142, 9.3%), ataxia (N = 134, 8.8%), and seizures (N = 126, 8.3%). These manifestations tended to differ with regard to age, general and neurological comorbidities, infection severity and non-neurological manifestations, extent of association with other acute/subacute neurological manifestations, and outcome.
CONCLUSIONS: Patients with COVID-19 and neurological manifestations present with distinct phenotypes. Differences in age, general and neurological comorbidities, and infection severity characterize the various neurological manifestations of COVID-19.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:30 |
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| Enthalten in: |
European journal of neurology - 30(2023), 2 vom: 30. Feb., Seite 413-433 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Beghi, Ettore [VerfasserIn] |
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| Links: |
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| Themen: |
COVID-19 |
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| Anmerkungen: |
Date Completed 06.01.2023 Date Revised 23.03.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/ene.15617 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM348287631 |
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| 100 | 1 | |a Beghi, Ettore |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Comparative features and outcomes of major neurological complications of COVID-19 |
| 264 | 1 | |c 2023 | |
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| 500 | |a Date Revised 23.03.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2022 European Academy of Neurology. | ||
| 520 | |a BACKGROUND AND PURPOSE: The aim of this study was to assess the neurological complications of SARS-CoV-2 infection and compare phenotypes and outcomes in infected patients with and without selected neurological manifestations | ||
| 520 | |a METHODS: The data source was a registry established by the European Academy of Neurology during the first wave of the COVID-19 pandemic. Neurologists collected data on patients with COVID-19 seen as in- and outpatients and in emergency rooms in 23 European and seven non-European countries. Prospective and retrospective data included patient demographics, lifestyle habits, comorbidities, main COVID-19 complications, hospital and intensive care unit admissions, diagnostic tests, and outcome. Acute/subacute selected neurological manifestations in patients with COVID-19 were analysed, comparing individuals with and without each condition for several risk factors | ||
| 520 | |a RESULTS: By July 31, 2021, 1523 patients (758 men, 756 women, and nine intersex/unknown, aged 16-101 years) were registered. Neurological manifestations were diagnosed in 1213 infected patients (79.6%). At study entry, 978 patients (64.2%) had one or more chronic general or neurological comorbidities. Predominant acute/subacute neurological manifestations were cognitive dysfunction (N = 449, 29.5%), stroke (N = 392, 25.7%), sleep-wake disturbances (N = 250, 16.4%), dysautonomia (N = 224, 14.7%), peripheral neuropathy (N = 145, 9.5%), movement disorders (N = 142, 9.3%), ataxia (N = 134, 8.8%), and seizures (N = 126, 8.3%). These manifestations tended to differ with regard to age, general and neurological comorbidities, infection severity and non-neurological manifestations, extent of association with other acute/subacute neurological manifestations, and outcome | ||
| 520 | |a CONCLUSIONS: Patients with COVID-19 and neurological manifestations present with distinct phenotypes. Differences in age, general and neurological comorbidities, and infection severity characterize the various neurological manifestations of COVID-19 | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a coronavirus | |
| 650 | 4 | |a neurological complications | |
| 650 | 4 | |a neurology | |
| 700 | 1 | |a Moro, Elena |e verfasserin |4 aut | |
| 700 | 1 | |a Davidescu, Eugenia Irene |e verfasserin |4 aut | |
| 700 | 1 | |a Popescu, Bogdan Ovidiu |e verfasserin |4 aut | |
| 700 | 1 | |a Grosu, Oxana |e verfasserin |4 aut | |
| 700 | 1 | |a Valzania, Franco |e verfasserin |4 aut | |
| 700 | 1 | |a Cotelli, Maria Sofia |e verfasserin |4 aut | |
| 700 | 1 | |a Kiteva-Trenchevska, Gordana |e verfasserin |4 aut | |
| 700 | 1 | |a Zakharova, Maria |e verfasserin |4 aut | |
| 700 | 1 | |a Kovács, Tibor |e verfasserin |4 aut | |
| 700 | 1 | |a Armon, Carmel |e verfasserin |4 aut | |
| 700 | 1 | |a Brola, Waldemar |e verfasserin |4 aut | |
| 700 | 1 | |a Yasuda, Clarissa Lin |e verfasserin |4 aut | |
| 700 | 1 | |a Maia, Luís F |e verfasserin |4 aut | |
| 700 | 1 | |a Lovrencic-Huzjan, Arijana |e verfasserin |4 aut | |
| 700 | 1 | |a de Seabra, Mafalda Maria Laracho |e verfasserin |4 aut | |
| 700 | 1 | |a Avalos-Pavon, Rafael |e verfasserin |4 aut | |
| 700 | 1 | |a Aamodt, Anne Hege |e verfasserin |4 aut | |
| 700 | 1 | |a Meoni, Sara |e verfasserin |4 aut | |
| 700 | 1 | |a Gryb, Victoria |e verfasserin |4 aut | |
| 700 | 1 | |a Ozturk, Serefnur |e verfasserin |4 aut | |
| 700 | 1 | |a Karadas, Omer |e verfasserin |4 aut | |
| 700 | 1 | |a Krehan, Ingomar |e verfasserin |4 aut | |
| 700 | 1 | |a Leone, Maurizio A |e verfasserin |4 aut | |
| 700 | 1 | |a Lolich, Maria |e verfasserin |4 aut | |
| 700 | 1 | |a Bianchi, Elisa |e verfasserin |4 aut | |
| 700 | 1 | |a Rass, Verena |e verfasserin |4 aut | |
| 700 | 1 | |a Helbok, Raimund |e verfasserin |4 aut | |
| 700 | 1 | |a Bassetti, Claudio L A |e verfasserin |4 aut | |
| 700 | 0 | |a ENERGY Study Group |e verfasserin |4 aut | |
| 700 | 1 | |a Ivan, Paula Andreea |e investigator |4 oth | |
| 700 | 1 | |a Sandu, Georgiana |e investigator |4 oth | |
| 700 | 1 | |a Odajiu, Irina |e investigator |4 oth | |
| 700 | 1 | |a Dragoș Sandu, Constantin |e investigator |4 oth | |
| 700 | 1 | |a Vitalie, Lisnic |e investigator |4 oth | |
| 700 | 1 | |a Mikhail, Gavriliuc |e investigator |4 oth | |
| 700 | 1 | |a Olesea, Odainic |e investigator |4 oth | |
| 700 | 1 | |a Cavallieri, Francesco |e investigator |4 oth | |
| 700 | 1 | |a Toschi, Giulia |e investigator |4 oth | |
| 700 | 1 | |a Zedde, Marialuisa |e investigator |4 oth | |
| 700 | 1 | |a Turla, Marinella |e investigator |4 oth | |
| 700 | 1 | |a Bianchi, Marta |e investigator |4 oth | |
| 700 | 1 | |a Civelli, Patrizia |e investigator |4 oth | |
| 700 | 1 | |a Cvetkovska, Emilija |e investigator |4 oth | |
| 700 | 1 | |a Barbov, Ivan |e investigator |4 oth | |
| 700 | 1 | |a Babunovska, Marija |e investigator |4 oth | |
| 700 | 1 | |a Kozlova, Alexandra |e investigator |4 oth | |
| 700 | 1 | |a Abramova, Anna |e investigator |4 oth | |
| 700 | 1 | |a Daria, Eliseeva |e investigator |4 oth | |
| 700 | 1 | |a Dobronyi, Levente |e investigator |4 oth | |
| 700 | 1 | |a Dénes, Kitti |e investigator |4 oth | |
| 700 | 1 | |a Bereczki, Dániel |e investigator |4 oth | |
| 700 | 1 | |a Agajany, Netta |e investigator |4 oth | |
| 700 | 1 | |a Geva, Matan |e investigator |4 oth | |
| 700 | 1 | |a Kindl, Philipp |e investigator |4 oth | |
| 700 | 1 | |a Kosno, Krystian |e investigator |4 oth | |
| 700 | 1 | |a Michał, Lipowski |e investigator |4 oth | |
| 700 | 1 | |a Silva, Lucas Scardua |e investigator |4 oth | |
| 700 | 1 | |a Batista João, Rafael |e investigator |4 oth | |
| 700 | 1 | |a Jung, Simon |e investigator |4 oth | |
| 700 | 1 | |a Müller, Madlaine |e investigator |4 oth | |
| 700 | 1 | |a Aires, Elaine |e investigator |4 oth | |
| 700 | 1 | |a Vinski, Ivana |e investigator |4 oth | |
| 700 | 1 | |a Lisak, Marijana |e investigator |4 oth | |
| 700 | 1 | |a Marjiana, Lesiv |e investigator |4 oth | |
| 700 | 1 | |a Ural, Onur |e investigator |4 oth | |
| 700 | 1 | |a Kara, Iskender |e investigator |4 oth | |
| 700 | 1 | |a Öztürk, Bilgin |e investigator |4 oth | |
| 700 | 1 | |a Caldeiras, Ana Catarina Oliveira |e investigator |4 oth | |
| 700 | 1 | |a Rodriguez-Leyva, Ildefonso |e investigator |4 oth | |
| 700 | 1 | |a Boldingh, Marion |e investigator |4 oth | |
| 700 | 1 | |a von Oertzen, Tim |e investigator |4 oth | |
| 700 | 1 | |a Jenkins, Thomas M |e investigator |4 oth | |
| 700 | 1 | |a Riahi, Anis |e investigator |4 oth | |
| 700 | 1 | |a Taba, Pille |e investigator |4 oth | |
| 700 | 1 | |a Azzam, Ahmed Y |e investigator |4 oth | |
| 700 | 1 | |a Wojtecki, Lars |e investigator |4 oth | |
| 700 | 1 | |a Sellner, Johan |e investigator |4 oth | |
| 700 | 1 | |a Castillo, Sergio |e investigator |4 oth | |
| 700 | 1 | |a Bušková, Jitka |e investigator |4 oth | |
| 700 | 1 | |a Novotny, Vojtech |e investigator |4 oth | |
| 700 | 1 | |a Jelcic, Ilijas |e investigator |4 oth | |
| 700 | 1 | |a Dafea, Ahmed |e investigator |4 oth | |
| 700 | 1 | |a Medina, Marco T |e investigator |4 oth | |
| 700 | 1 | |a Flemen, Heidi Øyen |e investigator |4 oth | |
| 700 | 1 | |a Elbahnasawy, Mohamed Gamal |e investigator |4 oth | |
| 700 | 1 | |a Kohler, Edith |e investigator |4 oth | |
| 700 | 1 | |a Farmen, Annette Huuse |e investigator |4 oth | |
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