Association Between Ambulatory Blood Pressure and Risk of Home Hypertension in a Normotensive Population : The Ohasama Study
© The Author(s) 2022. Published by Oxford University Press on behalf of American Journal of Hypertension, Ltd. All rights reserved. For permissions, please e-mail: journals.permissionsoup.com..
BACKGROUND: We investigated the association between ambulatory blood pressure (BP) and the risk of home hypertension in a normotensive population and whether considering ambulatory BP improves the 10-year prediction model for home hypertension risk, which was developed in the previous Ohasama Study.
METHODS: In this prospective study, we followed up with 410 participants (83.2% women; age, 53.6 years) without a home and ambulatory hypertension in the general population of Ohasama, Japan. The Cox model was used to assess the hazard ratios (HRs) for home hypertension (home BP ≥ 135/≥85 mmHg or the initiation of antihypertensive treatment) and model improvement.
RESULTS: During a mean 14.2-year follow-up, 225 home hypertension incidences occurred. The HR (95% confidence interval) for home hypertension incidence per 1-SD higher (=6.76 mmHg) 24-hour systolic BP (SBP) was 1.59 (1.33 to 1.90), after adjustments for possible confounding factors, including baseline home SBP. Harrell's C-statistics increased from 0.72 to 0.73 (P = 0.11) when 24-hour SBP was added to the basic 10-year home hypertension prediction model, which includes sex, age, body mass index, smoking status, office SBP, and baseline home SBP. Continuous net reclassification improvement (0.53, P < 0.0001) and integrated discrimination improvement (0.028, P = 0.0014) revealed improvement in the model.
CONCLUSIONS: A total of 24-hour SBP could be an independent predictor of future home hypertension. Home BP and 24-hour BP can longitudinally influence each other in the long term.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:36 |
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| Enthalten in: |
American journal of hypertension - 36(2023), 3 vom: 24. Feb., Seite 151-158 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Nakayama, Shingo [VerfasserIn] |
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| Links: |
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| Themen: |
Ambulatory blood pressure |
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| Anmerkungen: |
Date Completed 27.02.2023 Date Revised 10.03.2023 published: Print Citation Status MEDLINE |
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| doi: |
10.1093/ajh/hpac121 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM348241542 |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © The Author(s) 2022. Published by Oxford University Press on behalf of American Journal of Hypertension, Ltd. All rights reserved. For permissions, please e-mail: journals.permissionsoup.com. | ||
| 520 | |a BACKGROUND: We investigated the association between ambulatory blood pressure (BP) and the risk of home hypertension in a normotensive population and whether considering ambulatory BP improves the 10-year prediction model for home hypertension risk, which was developed in the previous Ohasama Study | ||
| 520 | |a METHODS: In this prospective study, we followed up with 410 participants (83.2% women; age, 53.6 years) without a home and ambulatory hypertension in the general population of Ohasama, Japan. The Cox model was used to assess the hazard ratios (HRs) for home hypertension (home BP ≥ 135/≥85 mmHg or the initiation of antihypertensive treatment) and model improvement | ||
| 520 | |a RESULTS: During a mean 14.2-year follow-up, 225 home hypertension incidences occurred. The HR (95% confidence interval) for home hypertension incidence per 1-SD higher (=6.76 mmHg) 24-hour systolic BP (SBP) was 1.59 (1.33 to 1.90), after adjustments for possible confounding factors, including baseline home SBP. Harrell's C-statistics increased from 0.72 to 0.73 (P = 0.11) when 24-hour SBP was added to the basic 10-year home hypertension prediction model, which includes sex, age, body mass index, smoking status, office SBP, and baseline home SBP. Continuous net reclassification improvement (0.53, P < 0.0001) and integrated discrimination improvement (0.028, P = 0.0014) revealed improvement in the model | ||
| 520 | |a CONCLUSIONS: A total of 24-hour SBP could be an independent predictor of future home hypertension. Home BP and 24-hour BP can longitudinally influence each other in the long term | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a ambulatory blood pressure | |
| 650 | 4 | |a blood pressure | |
| 650 | 4 | |a cohort studies | |
| 650 | 4 | |a epidemiology | |
| 650 | 4 | |a home hypertension | |
| 650 | 4 | |a hypertension | |
| 650 | 7 | |a Antihypertensive Agents |2 NLM | |
| 700 | 1 | |a Satoh, Michihiro |e verfasserin |4 aut | |
| 700 | 1 | |a Metoki, Hirohito |e verfasserin |4 aut | |
| 700 | 1 | |a Murakami, Takahisa |e verfasserin |4 aut | |
| 700 | 1 | |a Tatsumi, Yukako |e verfasserin |4 aut | |
| 700 | 1 | |a Asayama, Kei |e verfasserin |4 aut | |
| 700 | 1 | |a Hara, Azusa |e verfasserin |4 aut | |
| 700 | 1 | |a Hirose, Takuo |e verfasserin |4 aut | |
| 700 | 1 | |a Tsubota-Utsugi, Megumi |e verfasserin |4 aut | |
| 700 | 1 | |a Kikuya, Masahiro |e verfasserin |4 aut | |
| 700 | 1 | |a Mori, Takefumi |e verfasserin |4 aut | |
| 700 | 1 | |a Hozawa, Atsushi |e verfasserin |4 aut | |
| 700 | 1 | |a Imai, Yutaka |e verfasserin |4 aut | |
| 700 | 1 | |a Ohkubo, Takayoshi |e verfasserin |4 aut | |
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