Neuropsychiatric manifestations in patients with systemic lupus erythematosus : about 108 cases in Cameroon
Copyright: Mapoure Njankouo Yacouba et al..
Few data on neuropsychiatric disorders in systemic lupus erythematosus (NPSLE) are available in sub-Saharan Africa. The purpose of this study was to determine their frequency and describe their features in Cameroon. We conducted a retrospective study collecting all the medical records of patients with systemic lupus erythematosus (SLE) hospitalized in the department of rheumatology of 3 hospitals in Cameroon from 2009 to 2019. Lupus activity was assessed using the SLE activity index (SLEDAI). A total of 108 records of patients with a mean age of 40.2 ± 13.7 years were included in the study. The frequency of NPSLE was 55.5% (n=60). Neuropsychiatric disorders were diagnosed concomitantly with SLE (37.0%; n = 40) while in 20 patients with SLE (18.5%) they occurred during the first year. When NPSLE were inaugural, central nervous system involvement was dominant, with demyelinating syndrome 27.8% (n=30) and headaches 21.3% (n=23). Mononeuropathy was the most frequent peripheral nervous system involvement (15.7%; n=17). Factors associated with NPSLE occurrence were malar rash (p=0.024), alopecia (p=0.024), very high lupus activity (p=0.011), arthralgia (p<0.001), anti-nuclear factor (p=0.002). NPSLE did not appear to influence either lupus activity (log rank p=0.227) or the probability of new onset lupus (log rank p=0.233). More than half of patients had NPSLE during the first year. The presence of cutaneous and articular signs, high lupus activity, and anti-nuclear factor were associated with the occurrence of NPSLE.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:42 |
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| Enthalten in: |
The Pan African medical journal - 42(2022) vom: 16., Seite 241 |
| Sprache: |
Französisch |
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| Weiterer Titel: |
Manifestations neuropsychiatriques au cours du lupus érythémateux systémique: à propos de 108 cas au Cameroun |
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| Beteiligte Personen: |
Yacouba, Mapoure Njankouo [VerfasserIn] |
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| Links: |
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| Themen: |
Cameroon |
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| Anmerkungen: |
Date Completed 31.10.2022 Date Revised 31.10.2022 published: Electronic-eCollection Citation Status MEDLINE |
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| doi: |
10.11604/pamj.2022.42.241.27227 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM348181663 |
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| 245 | 1 | 0 | |a Neuropsychiatric manifestations in patients with systemic lupus erythematosus |b about 108 cases in Cameroon |
| 246 | 3 | 3 | |a Manifestations neuropsychiatriques au cours du lupus érythémateux systémique: à propos de 108 cas au Cameroun |
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| 520 | |a Copyright: Mapoure Njankouo Yacouba et al. | ||
| 520 | |a Few data on neuropsychiatric disorders in systemic lupus erythematosus (NPSLE) are available in sub-Saharan Africa. The purpose of this study was to determine their frequency and describe their features in Cameroon. We conducted a retrospective study collecting all the medical records of patients with systemic lupus erythematosus (SLE) hospitalized in the department of rheumatology of 3 hospitals in Cameroon from 2009 to 2019. Lupus activity was assessed using the SLE activity index (SLEDAI). A total of 108 records of patients with a mean age of 40.2 ± 13.7 years were included in the study. The frequency of NPSLE was 55.5% (n=60). Neuropsychiatric disorders were diagnosed concomitantly with SLE (37.0%; n = 40) while in 20 patients with SLE (18.5%) they occurred during the first year. When NPSLE were inaugural, central nervous system involvement was dominant, with demyelinating syndrome 27.8% (n=30) and headaches 21.3% (n=23). Mononeuropathy was the most frequent peripheral nervous system involvement (15.7%; n=17). Factors associated with NPSLE occurrence were malar rash (p=0.024), alopecia (p=0.024), very high lupus activity (p=0.011), arthralgia (p<0.001), anti-nuclear factor (p=0.002). NPSLE did not appear to influence either lupus activity (log rank p=0.227) or the probability of new onset lupus (log rank p=0.233). More than half of patients had NPSLE during the first year. The presence of cutaneous and articular signs, high lupus activity, and anti-nuclear factor were associated with the occurrence of NPSLE | ||
| 650 | 4 | |a Case Reports | |
| 650 | 4 | |a English Abstract | |
| 650 | 4 | |a Cameroon | |
| 650 | 4 | |a Neurolupus | |
| 650 | 4 | |a systemic lupus erythematosus (SLE) | |
| 700 | 1 | |a Francine, Same Bebey |e verfasserin |4 aut | |
| 700 | 1 | |a Francois, Balla Nde Jean |e verfasserin |4 aut | |
| 700 | 1 | |a Paul, Eloundou Onomo |e verfasserin |4 aut | |
| 700 | 1 | |a Caroline, Kenmegne |e verfasserin |4 aut | |
| 700 | 1 | |a Daniel, Gams Massi |e verfasserin |4 aut | |
| 700 | 1 | |a Jacques, Doumbe |e verfasserin |4 aut | |
| 700 | 1 | |a Madeleine, Ngandeu Singwe |e verfasserin |4 aut | |
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