Clinical and functional evaluation of bone marrow aspirate concentrate vs autologous conditioned serum in the treatment of knee osteoarthritis
BACKGROUND AND AIM: The aim of this study was to compare the efficacy of a single Bone Marrow Aspirate Concentrate (BMAC) with a cycle of 4 Autologous Conditioned Serum (ACS) injections in the treatment of early-stage knee osteoarthritis (OA).
METHODS: Two groups of 12 patients with degenerative knee OA were treated with a single BMAC injection and with a cycle of 4 ACS injections respectively. Follow-up was set at baseline (t0), one-month (t1) and six-months (t2) evaluating VAS for pain, WOMAC index and range of motion (ROM).
RESULTS: We reported a significant improvement in WOMAC after BMAC injection both at t1 (p= 0,001) as well as t2 (p< 0,001), plus a reduction of VAS values in BMAC group at six months follow-up (p = 0,024). In contrast, no significant differences in ROM between the two groups were observed.
CONCLUSIONS: Both the approaches are safe and effective in the treatment of knee OA, with a major efficacy of BMAC.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:93 |
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| Enthalten in: |
Acta bio-medica : Atenei Parmensis - 93(2022), 5 vom: 26. Okt., Seite e2022222 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Vitali, Matteo [VerfasserIn] |
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| Anmerkungen: |
Date Completed 28.10.2022 Date Revised 26.01.2023 published: Electronic Citation Status MEDLINE |
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| doi: |
10.23750/abm.v93i5.12845 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM348146418 |
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| 245 | 1 | 0 | |a Clinical and functional evaluation of bone marrow aspirate concentrate vs autologous conditioned serum in the treatment of knee osteoarthritis |
| 264 | 1 | |c 2022 | |
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| 500 | |a Date Completed 28.10.2022 | ||
| 500 | |a Date Revised 26.01.2023 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND AND AIM: The aim of this study was to compare the efficacy of a single Bone Marrow Aspirate Concentrate (BMAC) with a cycle of 4 Autologous Conditioned Serum (ACS) injections in the treatment of early-stage knee osteoarthritis (OA) | ||
| 520 | |a METHODS: Two groups of 12 patients with degenerative knee OA were treated with a single BMAC injection and with a cycle of 4 ACS injections respectively. Follow-up was set at baseline (t0), one-month (t1) and six-months (t2) evaluating VAS for pain, WOMAC index and range of motion (ROM) | ||
| 520 | |a RESULTS: We reported a significant improvement in WOMAC after BMAC injection both at t1 (p= 0,001) as well as t2 (p< 0,001), plus a reduction of VAS values in BMAC group at six months follow-up (p = 0,024). In contrast, no significant differences in ROM between the two groups were observed | ||
| 520 | |a CONCLUSIONS: Both the approaches are safe and effective in the treatment of knee OA, with a major efficacy of BMAC | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Ometti, Marco |e verfasserin |4 aut | |
| 700 | 1 | |a Pironti, Pierluigi |e verfasserin |4 aut | |
| 700 | 1 | |a Salvato, Damiano |e verfasserin |4 aut | |
| 700 | 1 | |a Sandrucci, Alice |e verfasserin |4 aut | |
| 700 | 1 | |a Leone, Orlando |e verfasserin |4 aut | |
| 700 | 1 | |a Salini, Vincenzo |e verfasserin |4 aut | |
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