Radiographic assessment of the impact of sex and the circadian rhythm-dependent behaviour on gastrointestinal transit in the rat
Relatively little is known about the influence of sex and the circadian rhythm on gastrointestinal transit. However, these factors could have an important impact on aspects such as digestion, oral absorption of drugs or the clinical manifestation of gastrointestinal diseases, among others. Remarkably, preclinical models have scarcely taken these factors into consideration. In this study, we assessed the gastrointestinal transit of young adult Wistar Han rats of both sexes, under normal and inverted light cycle. To do this, serial radiographs were taken for 24 h (T0-T24) after intragastric barium administration and subsequently analysed to construct transit curves for each gastrointestinal region. Under a normal light cycle, transit curves were similar, except for a slower transit in females compared with males from T8 to T24. Under the inverted cycle, there was a significant acceleration in stomach emptying (similar in both sexes), emptying of the small intestine (even faster in females) and filling of the caecum and colon (which was also even faster in females). This study confirms, using X-ray non-invasive methods for the first time, that both sex and circadian rhythm (probably through its effect on behaviour) influence gastrointestinal transit in laboratory animals.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:57 |
|---|---|
| Enthalten in: |
Laboratory animals - 57(2023), 3 vom: 19. Juni, Seite 270-282 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Gálvez-Robleño, Carlos [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Circadian rhythm |
|---|
| Anmerkungen: |
Date Completed 22.06.2023 Date Revised 22.06.2023 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1177/00236772221124381 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM348135769 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM348135769 | ||
| 003 | DE-627 | ||
| 005 | 20231226035455.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1177/00236772221124381 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1160.xml |
| 035 | |a (DE-627)NLM348135769 | ||
| 035 | |a (NLM)36299170 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Gálvez-Robleño, Carlos |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Radiographic assessment of the impact of sex and the circadian rhythm-dependent behaviour on gastrointestinal transit in the rat |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 22.06.2023 | ||
| 500 | |a Date Revised 22.06.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Relatively little is known about the influence of sex and the circadian rhythm on gastrointestinal transit. However, these factors could have an important impact on aspects such as digestion, oral absorption of drugs or the clinical manifestation of gastrointestinal diseases, among others. Remarkably, preclinical models have scarcely taken these factors into consideration. In this study, we assessed the gastrointestinal transit of young adult Wistar Han rats of both sexes, under normal and inverted light cycle. To do this, serial radiographs were taken for 24 h (T0-T24) after intragastric barium administration and subsequently analysed to construct transit curves for each gastrointestinal region. Under a normal light cycle, transit curves were similar, except for a slower transit in females compared with males from T8 to T24. Under the inverted cycle, there was a significant acceleration in stomach emptying (similar in both sexes), emptying of the small intestine (even faster in females) and filling of the caecum and colon (which was also even faster in females). This study confirms, using X-ray non-invasive methods for the first time, that both sex and circadian rhythm (probably through its effect on behaviour) influence gastrointestinal transit in laboratory animals | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Circadian rhythm | |
| 650 | 4 | |a gastrointestinal transit | |
| 650 | 4 | |a radiographic methods | |
| 650 | 4 | |a rat | |
| 650 | 4 | |a sex | |
| 700 | 1 | |a López-Tofiño, Yolanda |e verfasserin |4 aut | |
| 700 | 1 | |a López-Gómez, Laura |e verfasserin |4 aut | |
| 700 | 1 | |a Bagüés, Ana |e verfasserin |4 aut | |
| 700 | 1 | |a Soto-Montenegro, María Luisa |e verfasserin |4 aut | |
| 700 | 1 | |a Abalo, Raquel |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Laboratory animals |d 1970 |g 57(2023), 3 vom: 19. Juni, Seite 270-282 |w (DE-627)NLM000335185 |x 1758-1117 |7 nnns |
| 773 | 1 | 8 | |g volume:57 |g year:2023 |g number:3 |g day:19 |g month:06 |g pages:270-282 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1177/00236772221124381 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 57 |j 2023 |e 3 |b 19 |c 06 |h 270-282 | ||