Pre-Frailty Phenotype and Arterial Stiffness in Older Adults Free of Cardiovascular Diseases
PURPOSE: Arterial stiffness is a subclinical marker of cardiovascular disease (CVD). The pre-frailty phenotype is associated with a higher risk for CVD. This study investigated the association between the pre-frailty phenotype and arterial stiffness in community-dwelling older adults without diagnosed CVD.
METHODS: In total, 249 community-dwelling older adults aged 60-80 years were included in this cross-sectional study. The pre-frailty phenotype was defined by the standardized Fried criteria (muscle weakness; slow walking speed; low physical activity; unintentional weight loss; self-reported exhaustion). Participants with one or two standardized Fried criteria were classified as pre-frail and those with zero criteria as robust. Arterial stiffness was measured by aortic pulse wave velocity (aPWV). The data were analyzed using the generalized linear model.
RESULTS: From 249 participants (66.1 ± 5.3 years; 79.5% females), 61.8% (n = 154) were pre-frail and 38.2% (n = 95) robust. Pre-frail older adults had a higher aPWV (β = 0.19 m/s; p = 0.007) compared to their robust peers.
CONCLUSIONS: The pre-frailty phenotype was associated with higher arterial stiffness in community-dwelling older adults aged 60-80 years. Pre-frail older adults may have a higher risk for CVD.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:19 |
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| Enthalten in: |
International journal of environmental research and public health - 19(2022), 20 vom: 18. Okt. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Macêdo, Geovani Araújo Dantas [VerfasserIn] |
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| Links: |
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| Themen: |
Aging |
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| Anmerkungen: |
Date Completed 28.10.2022 Date Revised 17.01.2023 published: Electronic Citation Status MEDLINE |
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| doi: |
10.3390/ijerph192013469 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM348084560 |
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| 100 | 1 | |a Macêdo, Geovani Araújo Dantas |e verfasserin |4 aut | |
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| 500 | |a Date Revised 17.01.2023 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a PURPOSE: Arterial stiffness is a subclinical marker of cardiovascular disease (CVD). The pre-frailty phenotype is associated with a higher risk for CVD. This study investigated the association between the pre-frailty phenotype and arterial stiffness in community-dwelling older adults without diagnosed CVD | ||
| 520 | |a METHODS: In total, 249 community-dwelling older adults aged 60-80 years were included in this cross-sectional study. The pre-frailty phenotype was defined by the standardized Fried criteria (muscle weakness; slow walking speed; low physical activity; unintentional weight loss; self-reported exhaustion). Participants with one or two standardized Fried criteria were classified as pre-frail and those with zero criteria as robust. Arterial stiffness was measured by aortic pulse wave velocity (aPWV). The data were analyzed using the generalized linear model | ||
| 520 | |a RESULTS: From 249 participants (66.1 ± 5.3 years; 79.5% females), 61.8% (n = 154) were pre-frail and 38.2% (n = 95) robust. Pre-frail older adults had a higher aPWV (β = 0.19 m/s; p = 0.007) compared to their robust peers | ||
| 520 | |a CONCLUSIONS: The pre-frailty phenotype was associated with higher arterial stiffness in community-dwelling older adults aged 60-80 years. Pre-frail older adults may have a higher risk for CVD | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a aging | |
| 650 | 4 | |a cardiovascular disease | |
| 650 | 4 | |a frailty | |
| 650 | 4 | |a pulse wave velocity | |
| 650 | 4 | |a vascular disease | |
| 700 | 1 | |a Freire, Yuri Alberto |e verfasserin |4 aut | |
| 700 | 1 | |a Browne, Rodrigo Alberto Vieira |e verfasserin |4 aut | |
| 700 | 1 | |a Câmara, Marcyo |e verfasserin |4 aut | |
| 700 | 1 | |a Cabral, Ludmila Lucena Pereira |e verfasserin |4 aut | |
| 700 | 1 | |a Schwade, Daniel |e verfasserin |4 aut | |
| 700 | 1 | |a Paulo-Pereira, Ronildo |e verfasserin |4 aut | |
| 700 | 1 | |a Silva, Raíssa de Melo |e verfasserin |4 aut | |
| 700 | 1 | |a Silva, Alana Monteiro Bispo |e verfasserin |4 aut | |
| 700 | 1 | |a Farias-Junior, Luiz Fernando |e verfasserin |4 aut | |
| 700 | 1 | |a Duhamel, Todd A |e verfasserin |4 aut | |
| 700 | 1 | |a Costa, Eduardo Caldas |e verfasserin |4 aut | |
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