Ketamine as potential treatment for postpartum depression : A narrative review
BACKGROUND: Postpartum depression (PPD) is a severe, debilitating mood disorder with consequences for both mothers and children, highlighting the need for rapid-acting and effective treatments for PPD. The aim of this narrative review is to synthesize the available literature on the administration of ketamine for PPD and propose ketamine as a viable and advantageous treatment.
METHODS: A search was conducted on MEDLINE/PubMed, PsycInfo, and Embase databases from inception to October 10, 2021 for preclinical studies, interventional studies (ie, open-label and randomized controlled trials), as well as systematic reviews and meta-analyses evaluating the use of ketamine in postpartum populations. Completed and ongoing clinical trials were identified on ClinicalTrials.gov.
RESULTS: Four clinical trials were identified. Results from this review support additional investigation into ketamine as a potential treatment for PPD.
CONCLUSIONS: Ketamine may be a favorable option for treating PPD due to its antidepressive and analgesic effects, short infusion time, and rapid clearance from the maternal bloodstream. However, there is insufficient evidence to support its use in this population, underscoring the importance of additional clinical research investigating ketamine for PPD.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2022 |
|---|---|
| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:34 |
|---|---|
| Enthalten in: |
Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists - 34(2022), 4 vom: 22. Nov., Seite 264-274 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Chen-Li, David [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
690G0D6V8H |
|---|
| Anmerkungen: |
Date Completed 27.10.2022 Date Revised 23.11.2022 published: Print Citation Status MEDLINE |
|---|
| doi: |
10.12788/acp.0082 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM347971636 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM347971636 | ||
| 003 | DE-627 | ||
| 005 | 20231226035107.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.12788/acp.0082 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1159.xml |
| 035 | |a (DE-627)NLM347971636 | ||
| 035 | |a (NLM)36282614 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Chen-Li, David |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Ketamine as potential treatment for postpartum depression |b A narrative review |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 27.10.2022 | ||
| 500 | |a Date Revised 23.11.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: Postpartum depression (PPD) is a severe, debilitating mood disorder with consequences for both mothers and children, highlighting the need for rapid-acting and effective treatments for PPD. The aim of this narrative review is to synthesize the available literature on the administration of ketamine for PPD and propose ketamine as a viable and advantageous treatment | ||
| 520 | |a METHODS: A search was conducted on MEDLINE/PubMed, PsycInfo, and Embase databases from inception to October 10, 2021 for preclinical studies, interventional studies (ie, open-label and randomized controlled trials), as well as systematic reviews and meta-analyses evaluating the use of ketamine in postpartum populations. Completed and ongoing clinical trials were identified on ClinicalTrials.gov | ||
| 520 | |a RESULTS: Four clinical trials were identified. Results from this review support additional investigation into ketamine as a potential treatment for PPD | ||
| 520 | |a CONCLUSIONS: Ketamine may be a favorable option for treating PPD due to its antidepressive and analgesic effects, short infusion time, and rapid clearance from the maternal bloodstream. However, there is insufficient evidence to support its use in this population, underscoring the importance of additional clinical research investigating ketamine for PPD | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 7 | |a Ketamine |2 NLM | |
| 650 | 7 | |a 690G0D6V8H |2 NLM | |
| 650 | 7 | |a Antidepressive Agents |2 NLM | |
| 650 | 7 | |a Analgesics |2 NLM | |
| 700 | 1 | |a Lui, Leanna M W |e verfasserin |4 aut | |
| 700 | 1 | |a Rosenblat, Joshua D |e verfasserin |4 aut | |
| 700 | 1 | |a Lipsitz, Orly |e verfasserin |4 aut | |
| 700 | 1 | |a Teopiz, Kayla M |e verfasserin |4 aut | |
| 700 | 1 | |a Ho, Roger |e verfasserin |4 aut | |
| 700 | 1 | |a Vinberg, Maj |e verfasserin |4 aut | |
| 700 | 1 | |a Golts, Marina |e verfasserin |4 aut | |
| 700 | 1 | |a Jawad, Muhammad Youshay |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Yena |e verfasserin |4 aut | |
| 700 | 1 | |a Nasri, Flora |e verfasserin |4 aut | |
| 700 | 1 | |a Gill, Hartej |e verfasserin |4 aut | |
| 700 | 1 | |a McIntyre, Roger S |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists |d 1996 |g 34(2022), 4 vom: 22. Nov., Seite 264-274 |w (DE-627)NLM074828983 |x 1547-3325 |7 nnns |
| 773 | 1 | 8 | |g volume:34 |g year:2022 |g number:4 |g day:22 |g month:11 |g pages:264-274 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.12788/acp.0082 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 34 |j 2022 |e 4 |b 22 |c 11 |h 264-274 | ||