Use of asprosin and subfatin for differential diagnosis of serous ovarian tumors
Asprosin (ASP) and subfatin are hormones that regulate glucose metabolism. The role of ASP and subfatin in serous ovarian tumors has not been investigated. We investigated the expression of subfatin and asprosin in 30 serous benign, 30 serous borderline, 30 malignant and 30 control ovarian tissues. We investigated ASP and subfatin immunoreactivity and quantification was achieved using an ELISA method. ASP and subfatin were localized in the epithelial parts of normal ovarian tissues; however, in cancer tissues, immunoreactivity was detected in the parenchymal areas. Biochemical analysis of ovarian tissues revealed significantly decreased ASP and subfatin compared to the control. We propose that ASP and subfatin are promising candidates for biomarkers to distinguish serous benign, serous borderline and malignant ovarian cancers.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:98 |
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| Enthalten in: |
Biotechnic & histochemistry : official publication of the Biological Stain Commission - 98(2023), 2 vom: 15. Feb., Seite 140-146 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Mirzaoglu, Miyase [VerfasserIn] |
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| Links: |
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| Themen: |
Asprosin |
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| Anmerkungen: |
Date Completed 07.02.2023 Date Revised 07.02.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1080/10520295.2022.2135763 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM347963358 |
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| 245 | 1 | 0 | |a Use of asprosin and subfatin for differential diagnosis of serous ovarian tumors |
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| 500 | |a Date Revised 07.02.2023 | ||
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Asprosin (ASP) and subfatin are hormones that regulate glucose metabolism. The role of ASP and subfatin in serous ovarian tumors has not been investigated. We investigated the expression of subfatin and asprosin in 30 serous benign, 30 serous borderline, 30 malignant and 30 control ovarian tissues. We investigated ASP and subfatin immunoreactivity and quantification was achieved using an ELISA method. ASP and subfatin were localized in the epithelial parts of normal ovarian tissues; however, in cancer tissues, immunoreactivity was detected in the parenchymal areas. Biochemical analysis of ovarian tissues revealed significantly decreased ASP and subfatin compared to the control. We propose that ASP and subfatin are promising candidates for biomarkers to distinguish serous benign, serous borderline and malignant ovarian cancers | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Asprosin | |
| 650 | 4 | |a meteorin-like protein | |
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| 650 | 4 | |a serous ovarian cancer | |
| 650 | 4 | |a subfatin | |
| 650 | 7 | |a Biomarkers, Tumor |2 NLM | |
| 700 | 1 | |a Yavuzkir, Seyda |e verfasserin |4 aut | |
| 700 | 1 | |a Mirzaoglu, Cetin |e verfasserin |4 aut | |
| 700 | 1 | |a Yurt, Nurdan |e verfasserin |4 aut | |
| 700 | 1 | |a Dagli, Adile Ferda |e verfasserin |4 aut | |
| 700 | 1 | |a Ozcan Yildirim, Sena |e verfasserin |4 aut | |
| 700 | 1 | |a Sahin, İbrahim |e verfasserin |4 aut | |
| 700 | 1 | |a Aydin, Suleyman |e verfasserin |4 aut | |
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