Neuroanatomical basis of sexual dimorphism in the mosquito brain
© 2022 The Author(s)..
Female but not male mosquitoes are vectors for multiple deadly human diseases including malaria, dengue, yellow fever, and West Nile virus. However, the underlying neural substrates of sexually dimorphic behaviors remain largely unknown in mosquitoes. In this study, we found striking sexual dimorphism in brain regions in two major disease vectors, Aedes aegypti and Culex quinquefasciatus, through voxel-wise comparison of the whole brain. Female-enlarged regions include those associated with chemosensation and vision, while male-enlarged regions are linked to hearing and memory. However, some brain regions associated with vision and memory are sexually dimorphic in A e . aegypti but not C x . quinquefasciatus. As the first global voxel-based comparative neuroanatomical analysis of mosquito brains between sexes, this study not only sheds light on the neural substrates underlying sex-specific behaviors, but also identifies regions of interest for future research to disrupt female-specific behaviors critical to disease transmission.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2022 |
---|---|
Erschienen: |
2022 |
Enthalten in: |
Zur Gesamtaufnahme - volume:25 |
---|---|
Enthalten in: |
iScience - 25(2022), 11 vom: 18. Nov., Seite 105255 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Li, Jing [VerfasserIn] |
---|
Links: |
---|
Themen: |
---|
Anmerkungen: |
Date Revised 25.10.2022 published: Electronic-eCollection Dryad: 10.5061/dryad.51c59zwbq Citation Status PubMed-not-MEDLINE |
---|
doi: |
10.1016/j.isci.2022.105255 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM347920551 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM347920551 | ||
003 | DE-627 | ||
005 | 20231226034955.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231226s2022 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1016/j.isci.2022.105255 |2 doi | |
028 | 5 | 2 | |a pubmed24n1159.xml |
035 | |a (DE-627)NLM347920551 | ||
035 | |a (NLM)36277452 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Li, Jing |e verfasserin |4 aut | |
245 | 1 | 0 | |a Neuroanatomical basis of sexual dimorphism in the mosquito brain |
264 | 1 | |c 2022 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Revised 25.10.2022 | ||
500 | |a published: Electronic-eCollection | ||
500 | |a Dryad: 10.5061/dryad.51c59zwbq | ||
500 | |a Citation Status PubMed-not-MEDLINE | ||
520 | |a © 2022 The Author(s). | ||
520 | |a Female but not male mosquitoes are vectors for multiple deadly human diseases including malaria, dengue, yellow fever, and West Nile virus. However, the underlying neural substrates of sexually dimorphic behaviors remain largely unknown in mosquitoes. In this study, we found striking sexual dimorphism in brain regions in two major disease vectors, Aedes aegypti and Culex quinquefasciatus, through voxel-wise comparison of the whole brain. Female-enlarged regions include those associated with chemosensation and vision, while male-enlarged regions are linked to hearing and memory. However, some brain regions associated with vision and memory are sexually dimorphic in A e . aegypti but not C x . quinquefasciatus. As the first global voxel-based comparative neuroanatomical analysis of mosquito brains between sexes, this study not only sheds light on the neural substrates underlying sex-specific behaviors, but also identifies regions of interest for future research to disrupt female-specific behaviors critical to disease transmission | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Animals | |
650 | 4 | |a Behavioral neuroscience | |
650 | 4 | |a Ethology | |
700 | 1 | |a Merchant, Austin |e verfasserin |4 aut | |
700 | 1 | |a Zhou, Suyue |e verfasserin |4 aut | |
700 | 1 | |a Wang, Tao |e verfasserin |4 aut | |
700 | 1 | |a Zhou, Xuguo |e verfasserin |4 aut | |
700 | 1 | |a Zhou, Chuan |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t iScience |d 2018 |g 25(2022), 11 vom: 18. Nov., Seite 105255 |w (DE-627)NLM285332627 |x 2589-0042 |7 nnns |
773 | 1 | 8 | |g volume:25 |g year:2022 |g number:11 |g day:18 |g month:11 |g pages:105255 |
856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.isci.2022.105255 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 25 |j 2022 |e 11 |b 18 |c 11 |h 105255 |