Dominance status is associated with a variation in cannabinoid receptor 1 expression and amphetamine reward
Copyright © 2022 Elsevier Inc. All rights reserved..
The rewarding effects of psychostimulants appear to be distinct between dominant and subordinate individuals. In turn, the endocannabinoid system is an important modulator of drug reward in the nucleus accumbens and medial prefrontal cortex, however the connection with social dominance is yet to be established. Male rats were classified as dominant or subordinate on the basis of their spontaneous agonistic interactions and drug reward was assessed by means of conditioned place preference with amphetamine (AMPH). In addition, the expression of CB1R, CB2R, FAAH1, and DAGLa was quantified from accumbal and cortical tissue samples. Our findings demonstrate that dominant rats required a lesser dose of AMPH to acquire a preference for the drug-associated compartment, thereby suggesting a higher sensitivity to the rewarding effects of AMPH. Furthermore, dominants exhibited a lower expression of CB1R in the medial prefrontal cortex and nucleus accumbens. This study illustrates how CBR1 expression could differentiate the behavioral phenotypes associated to social dominance.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:221 |
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| Enthalten in: |
Pharmacology, biochemistry, and behavior - 221(2022) vom: 01. Nov., Seite 173483 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Migliaro, Martin [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 12.12.2022 Date Revised 13.12.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.pbb.2022.173483 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM347849571 |
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| 245 | 1 | 0 | |a Dominance status is associated with a variation in cannabinoid receptor 1 expression and amphetamine reward |
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| 500 | |a Date Revised 13.12.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2022 Elsevier Inc. All rights reserved. | ||
| 520 | |a The rewarding effects of psychostimulants appear to be distinct between dominant and subordinate individuals. In turn, the endocannabinoid system is an important modulator of drug reward in the nucleus accumbens and medial prefrontal cortex, however the connection with social dominance is yet to be established. Male rats were classified as dominant or subordinate on the basis of their spontaneous agonistic interactions and drug reward was assessed by means of conditioned place preference with amphetamine (AMPH). In addition, the expression of CB1R, CB2R, FAAH1, and DAGLa was quantified from accumbal and cortical tissue samples. Our findings demonstrate that dominant rats required a lesser dose of AMPH to acquire a preference for the drug-associated compartment, thereby suggesting a higher sensitivity to the rewarding effects of AMPH. Furthermore, dominants exhibited a lower expression of CB1R in the medial prefrontal cortex and nucleus accumbens. This study illustrates how CBR1 expression could differentiate the behavioral phenotypes associated to social dominance | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a CB1R | |
| 650 | 4 | |a Dominance status | |
| 650 | 4 | |a Drug reward | |
| 650 | 4 | |a Endocannabinoid system | |
| 650 | 4 | |a Psychostimulant | |
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| 650 | 7 | |a Central Nervous System Stimulants |2 NLM | |
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| 700 | 1 | |a Sánchez-Zavaleta, Rodolfo |e verfasserin |4 aut | |
| 700 | 1 | |a Soto-Tinoco, Eva |e verfasserin |4 aut | |
| 700 | 1 | |a Ruiz-Contreras, Alejandra E |e verfasserin |4 aut | |
| 700 | 1 | |a Méndez-Díaz, Mónica |e verfasserin |4 aut | |
| 700 | 1 | |a Herrera-Solís, Andrea |e verfasserin |4 aut | |
| 700 | 1 | |a Pérez de la Mora, Miguel |e verfasserin |4 aut | |
| 700 | 1 | |a Prospéro-García, Oscar E |e verfasserin |4 aut | |
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