A Systematic Review and Meta-analysis of the Association Between SARS-CoV-2 Vaccination and Myocarditis or Pericarditis
Copyright © 2022 American Journal of Preventive Medicine. Published by Elsevier Inc. All rights reserved..
INTRODUCTION: There have been reports of potential negative cardiovascular effects from the COVID-19 vaccine, such as myocarditis or pericarditis. This study sought to ascertain the risk of myocarditis/pericarditis after COVID-19 vaccination by conducting an extensive meta-analysis of published cases.
METHODS: A systematic literature search was conducted in 7 online databases by March 31, 2022. Heterogeneity was tested by I2 index. RR and 95% CI were pooled through either random-effect or fixed-effect models. Sensitivity analysis and publication bias were also conducted.
RESULTS: A total of 11 studies with 58,620,611 subjects were included. COVID-19 vaccination correlated with an increased risk of myocarditis or pericarditis (RR=2.04; 95% CI=1.33, 3.14). In addition, an increased risk of myocarditis or pericarditis in people who received the second dose of COVID-19 vaccine compared with that in those who received only the first dose of COVID-19 vaccine was also found (RR=4.06; 95% CI=2.08, 7.92). An increased incidence of pericarditis or myocarditis was noted predominantly in those who received BNT162b2 and mRNA-1273 vaccines (RR=2.19; 95% CI=1.46, 3.29 and RR=4.15; 95% CI=1.87, 9.22, respectively).
DISCUSSION: Study results indicate that a higher incidence of myocarditis or pericarditis was found after COVID-19 vaccination. In addition, the risk of developing myocarditis or pericarditis was greater after the second dose than after the first dose. Nevertheless, the risks of myocarditis and pericarditis in COVID-19 vaccine recipients are still significantly lower than the health risks observed in patients with COVID-19. Therefore, the benefits and harms must be carefully assessed to determine the best management option for patients who are in the high-risk group of myocarditis or pericarditis.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2023 |
---|---|
Erschienen: |
2023 |
Enthalten in: |
Zur Gesamtaufnahme - volume:64 |
---|---|
Enthalten in: |
American journal of preventive medicine - 64(2023), 2 vom: 17. Feb., Seite 275-284 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Gao, Juan [VerfasserIn] |
---|
Links: |
---|
Themen: |
2019-nCoV Vaccine mRNA-1273 |
---|
Anmerkungen: |
Date Completed 23.01.2023 Date Revised 15.02.2023 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.1016/j.amepre.2022.09.002 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM347807658 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM347807658 | ||
003 | DE-627 | ||
005 | 20231226034719.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231226s2023 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1016/j.amepre.2022.09.002 |2 doi | |
028 | 5 | 2 | |a pubmed24n1159.xml |
035 | |a (DE-627)NLM347807658 | ||
035 | |a (NLM)36266115 | ||
035 | |a (PII)S0749-3797(22)00453-6 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Gao, Juan |e verfasserin |4 aut | |
245 | 1 | 2 | |a A Systematic Review and Meta-analysis of the Association Between SARS-CoV-2 Vaccination and Myocarditis or Pericarditis |
264 | 1 | |c 2023 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 23.01.2023 | ||
500 | |a Date Revised 15.02.2023 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Copyright © 2022 American Journal of Preventive Medicine. Published by Elsevier Inc. All rights reserved. | ||
520 | |a INTRODUCTION: There have been reports of potential negative cardiovascular effects from the COVID-19 vaccine, such as myocarditis or pericarditis. This study sought to ascertain the risk of myocarditis/pericarditis after COVID-19 vaccination by conducting an extensive meta-analysis of published cases | ||
520 | |a METHODS: A systematic literature search was conducted in 7 online databases by March 31, 2022. Heterogeneity was tested by I2 index. RR and 95% CI were pooled through either random-effect or fixed-effect models. Sensitivity analysis and publication bias were also conducted | ||
520 | |a RESULTS: A total of 11 studies with 58,620,611 subjects were included. COVID-19 vaccination correlated with an increased risk of myocarditis or pericarditis (RR=2.04; 95% CI=1.33, 3.14). In addition, an increased risk of myocarditis or pericarditis in people who received the second dose of COVID-19 vaccine compared with that in those who received only the first dose of COVID-19 vaccine was also found (RR=4.06; 95% CI=2.08, 7.92). An increased incidence of pericarditis or myocarditis was noted predominantly in those who received BNT162b2 and mRNA-1273 vaccines (RR=2.19; 95% CI=1.46, 3.29 and RR=4.15; 95% CI=1.87, 9.22, respectively) | ||
520 | |a DISCUSSION: Study results indicate that a higher incidence of myocarditis or pericarditis was found after COVID-19 vaccination. In addition, the risk of developing myocarditis or pericarditis was greater after the second dose than after the first dose. Nevertheless, the risks of myocarditis and pericarditis in COVID-19 vaccine recipients are still significantly lower than the health risks observed in patients with COVID-19. Therefore, the benefits and harms must be carefully assessed to determine the best management option for patients who are in the high-risk group of myocarditis or pericarditis | ||
650 | 4 | |a Meta-Analysis | |
650 | 4 | |a Systematic Review | |
650 | 4 | |a Journal Article | |
650 | 4 | |a Review | |
650 | 7 | |a BNT162 Vaccine |2 NLM | |
650 | 7 | |a COVID-19 Vaccines |2 NLM | |
650 | 7 | |a 2019-nCoV Vaccine mRNA-1273 |2 NLM | |
650 | 7 | |a EPK39PL4R4 |2 NLM | |
700 | 1 | |a Feng, Linya |e verfasserin |4 aut | |
700 | 1 | |a Li, Yaru |e verfasserin |4 aut | |
700 | 1 | |a Lowe, Scott |e verfasserin |4 aut | |
700 | 1 | |a Guo, Zhichun |e verfasserin |4 aut | |
700 | 1 | |a Bentley, Rachel |e verfasserin |4 aut | |
700 | 1 | |a Xie, Chuman |e verfasserin |4 aut | |
700 | 1 | |a Wu, Birong |e verfasserin |4 aut | |
700 | 1 | |a Xie, Peng |e verfasserin |4 aut | |
700 | 1 | |a Xia, Weihang |e verfasserin |4 aut | |
700 | 1 | |a Ma, Shaodi |e verfasserin |4 aut | |
700 | 1 | |a Liu, Haixia |e verfasserin |4 aut | |
700 | 1 | |a Guo, Xianwei |e verfasserin |4 aut | |
700 | 1 | |a Uy, John Patrick N |e verfasserin |4 aut | |
700 | 1 | |a Zhou, Qin |e verfasserin |4 aut | |
700 | 1 | |a Wazir, Hina |e verfasserin |4 aut | |
700 | 1 | |a Sun, Chenyu |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t American journal of preventive medicine |d 1987 |g 64(2023), 2 vom: 17. Feb., Seite 275-284 |w (DE-627)NLM01367370X |x 1873-2607 |7 nnns |
773 | 1 | 8 | |g volume:64 |g year:2023 |g number:2 |g day:17 |g month:02 |g pages:275-284 |
856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.amepre.2022.09.002 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 64 |j 2023 |e 2 |b 17 |c 02 |h 275-284 |