Additional prognostic value of echocardiographic follow-up in pulmonary hypertension-role of 3D right ventricular area strain
Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2021. For permissions, please email: journals.permissionsoup.com..
AIMS: Outcomes in pulmonary hypertension (PH) are related to right ventricular (RV) function and remodelling. We hypothesized that changes in RV function and especially area strain (AS) could provide incremental prognostic information compared to the use of baseline data only. We therefore aimed to assess RV function changes between baseline and 6-month follow-up and evaluate their prognostic value for PH patients using 3D echocardiography.
METHODS AND RESULTS: Ninety-five PH patients underwent a prospective longitudinal study including ESC/ERS guidelines prognostic assessment and 3D RV echocardiographic imaging at baseline and 6-month follow-up. Semi-automatic software tracked the RV along the cycle, and its output was post-processed to extract 3D deformation patterns. Over a median follow-up of 24.8 (22.1-25.7) months, 21 patients died from PH or were transplanted. Improvements in RV global AS were associated with stable or improving clinical condition as well as survival free from transplant (P < 0.001). The 3D deformation patterns confirmed that the most significant regional changes occurred within the septum. RV global AS change over 6-month by +3.5% identifies patients with a 3.7-fold increased risk of death or transplant. On multivariate COX analysis, changes in WHO class, BNP, and RV global AS were independent predictors of outcomes. Besides, the combination of these three parameters was of special interest to identify high-risk patients [HR 11.5 (1.55-86.06)].
CONCLUSION: Changes in RV function and especially changes in 3D RV AS are of prognostic importance. Our study underlines that assessing such changes from baseline to follow-up is of additional prognostic value for PH patients.
CLINICAL TRIAL REGISTRATION: http://clinicaltrials.gov/ct2/show/NCT02799979.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:23 |
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| Enthalten in: |
European heart journal. Cardiovascular Imaging - 23(2022), 11 vom: 20. Okt., Seite 1562-1572 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Moceri, Pamela [VerfasserIn] |
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| Links: |
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| Themen: |
3d echocardiography |
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| Anmerkungen: |
Date Completed 26.10.2022 Date Revised 15.11.2022 published: Print ClinicalTrials.gov: NCT02799979 Citation Status MEDLINE |
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| doi: |
10.1093/ehjci/jeab240 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM347798365 |
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| 100 | 1 | |a Moceri, Pamela |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Additional prognostic value of echocardiographic follow-up in pulmonary hypertension-role of 3D right ventricular area strain |
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| 500 | |a Date Revised 15.11.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a ClinicalTrials.gov: NCT02799979 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2021. For permissions, please email: journals.permissionsoup.com. | ||
| 520 | |a AIMS: Outcomes in pulmonary hypertension (PH) are related to right ventricular (RV) function and remodelling. We hypothesized that changes in RV function and especially area strain (AS) could provide incremental prognostic information compared to the use of baseline data only. We therefore aimed to assess RV function changes between baseline and 6-month follow-up and evaluate their prognostic value for PH patients using 3D echocardiography | ||
| 520 | |a METHODS AND RESULTS: Ninety-five PH patients underwent a prospective longitudinal study including ESC/ERS guidelines prognostic assessment and 3D RV echocardiographic imaging at baseline and 6-month follow-up. Semi-automatic software tracked the RV along the cycle, and its output was post-processed to extract 3D deformation patterns. Over a median follow-up of 24.8 (22.1-25.7) months, 21 patients died from PH or were transplanted. Improvements in RV global AS were associated with stable or improving clinical condition as well as survival free from transplant (P < 0.001). The 3D deformation patterns confirmed that the most significant regional changes occurred within the septum. RV global AS change over 6-month by +3.5% identifies patients with a 3.7-fold increased risk of death or transplant. On multivariate COX analysis, changes in WHO class, BNP, and RV global AS were independent predictors of outcomes. Besides, the combination of these three parameters was of special interest to identify high-risk patients [HR 11.5 (1.55-86.06)] | ||
| 520 | |a CONCLUSION: Changes in RV function and especially changes in 3D RV AS are of prognostic importance. Our study underlines that assessing such changes from baseline to follow-up is of additional prognostic value for PH patients | ||
| 520 | |a CLINICAL TRIAL REGISTRATION: http://clinicaltrials.gov/ct2/show/NCT02799979 | ||
| 650 | 4 | |a Clinical Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a 3d echocardiography | |
| 650 | 4 | |a myocardial deformation imaging | |
| 650 | 4 | |a pulmonary hypertension | |
| 650 | 4 | |a right ventricular function | |
| 700 | 1 | |a Duchateau, Nicolas |e verfasserin |4 aut | |
| 700 | 1 | |a Baudouy, Delphine |e verfasserin |4 aut | |
| 700 | 1 | |a Squara, Fabien |e verfasserin |4 aut | |
| 700 | 1 | |a Bun, Sok Sithikun |e verfasserin |4 aut | |
| 700 | 1 | |a Ferrari, Emile |e verfasserin |4 aut | |
| 700 | 1 | |a Sermesant, Maxime |e verfasserin |4 aut | |
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