Efficacy of Cold Atmospheric Plasma Therapy on Chronic Wounds : An Updated Systematic Review and Meta-Analysis of RCTs
Copyright © 2022 Julan Guo et al..
Objective: A previous meta-analysis has revealed that cold atmospheric plasma (CAP) might not be clinically beneficial to chronic wounds. However, several new randomized controlled trials (RCTs) reported that CAP was an effective treatment option for accelerating wound healing in chronic wounds. The purpose of this review is to incorporate these new results and evaluate the efficacy of CAP in chronic wounds.
Methods: The major databases, including PubMed, Embase, Cochrane Library, and Web of Science, were searched for articles related to CAP treatment in chronic wounds until March 21, 2022. The literature retrieval and evaluation were carried out by two independent researchers.
Result: A total of 13 randomized clinical trials published between 2010 and 2022 were finally included. CAP therapy showed to be more effective in reducing the area of wounds (mean difference (MD): -1.74, 95%; confidence interval (CI): [-3.14, -0.33], p = 0.02), compared with non-CAP treatments. The immediate reduction of the bacterial load was higher in the CAP group than in the control group. (MD: -0.37, 95%; CI: [-0.7, -0.05], p = 0.02).
Conclusion: No significant changes were found in long-term antibacterial efficacy and pain perception between the two groups. However, more RCTs of excellent methodological quality are required to confirm technical details of the source of AP and the appropriate duration of the treatment with plasma.
| Errataetall: |
RetractionIn: Comput Math Methods Med. 2023 Nov 29;2023:9814529. - PMID 38077854 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:2022 |
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| Enthalten in: |
Computational and mathematical methods in medicine - 2022(2022) vom: 06., Seite 5798857 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Guo, Julan [VerfasserIn] |
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| Links: |
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| Themen: |
Anti-Bacterial Agents |
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| Anmerkungen: |
Date Completed 21.10.2022 Date Revised 11.12.2023 published: Electronic-eCollection RetractionIn: Comput Math Methods Med. 2023 Nov 29;2023:9814529. - PMID 38077854 Citation Status MEDLINE |
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| doi: |
10.1155/2022/5798857 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM347775454 |
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| 500 | |a RetractionIn: Comput Math Methods Med. 2023 Nov 29;2023:9814529. - PMID 38077854 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2022 Julan Guo et al. | ||
| 520 | |a Objective: A previous meta-analysis has revealed that cold atmospheric plasma (CAP) might not be clinically beneficial to chronic wounds. However, several new randomized controlled trials (RCTs) reported that CAP was an effective treatment option for accelerating wound healing in chronic wounds. The purpose of this review is to incorporate these new results and evaluate the efficacy of CAP in chronic wounds | ||
| 520 | |a Methods: The major databases, including PubMed, Embase, Cochrane Library, and Web of Science, were searched for articles related to CAP treatment in chronic wounds until March 21, 2022. The literature retrieval and evaluation were carried out by two independent researchers | ||
| 520 | |a Result: A total of 13 randomized clinical trials published between 2010 and 2022 were finally included. CAP therapy showed to be more effective in reducing the area of wounds (mean difference (MD): -1.74, 95%; confidence interval (CI): [-3.14, -0.33], p = 0.02), compared with non-CAP treatments. The immediate reduction of the bacterial load was higher in the CAP group than in the control group. (MD: -0.37, 95%; CI: [-0.7, -0.05], p = 0.02) | ||
| 520 | |a Conclusion: No significant changes were found in long-term antibacterial efficacy and pain perception between the two groups. However, more RCTs of excellent methodological quality are required to confirm technical details of the source of AP and the appropriate duration of the treatment with plasma | ||
| 650 | 4 | |a Meta-Analysis | |
| 650 | 4 | |a Systematic Review | |
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| 650 | 4 | |a Retracted Publication | |
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| 650 | 7 | |a Anti-Bacterial Agents |2 NLM | |
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| 700 | 1 | |a Xu, Bojun |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Jiao |e verfasserin |4 aut | |
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