Neuroplasticity in Depression : A Narrative Review with Evidence-Based Insights
Major Depressive Disorder (MDD) is one of the leading causes of disability worldwide. The current pharmacological treatment options for MDD, which rely on the mono-amine hypothesis, has their limitations with respect to treatment non-response, partial response etc. This propels for a search for a novel neurobiological understanding of MDD that can lead to novel treatment options. A literature search strategy was thus employed using relevant keywords pertaining to the topic in PubMed, Embase and Google Scholar. Systematic reviews and meta-analyses, narrative reviews and clinical trials were reviewed to incorporate the most robust evidence-based literature available. A total of 37 publications were narrowed down based upon the topic. Alterations in brain neuroplasticity, as evidenced by changes in neurotrophic factors and from neuroimaging, has been found to be a strong patho-mechanism for MDD. This link has been exploited to stimulate psychopharmacological research to treat MDD.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2022 |
|---|---|
| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:34 |
|---|---|
| Enthalten in: |
Psychiatria Danubina - 34(2022), 3 vom: 14., Seite 390-397 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Mudgal, Shiv Kumar [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
|---|
| Anmerkungen: |
Date Completed 20.10.2022 Date Revised 20.10.2022 published: Print Citation Status MEDLINE |
|---|
| doi: |
10.24869/psyd.2022.390 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM347717608 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM347717608 | ||
| 003 | DE-627 | ||
| 005 | 20231226034511.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.24869/psyd.2022.390 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1159.xml |
| 035 | |a (DE-627)NLM347717608 | ||
| 035 | |a (NLM)36256972 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Mudgal, Shiv Kumar |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Neuroplasticity in Depression |b A Narrative Review with Evidence-Based Insights |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 20.10.2022 | ||
| 500 | |a Date Revised 20.10.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Major Depressive Disorder (MDD) is one of the leading causes of disability worldwide. The current pharmacological treatment options for MDD, which rely on the mono-amine hypothesis, has their limitations with respect to treatment non-response, partial response etc. This propels for a search for a novel neurobiological understanding of MDD that can lead to novel treatment options. A literature search strategy was thus employed using relevant keywords pertaining to the topic in PubMed, Embase and Google Scholar. Systematic reviews and meta-analyses, narrative reviews and clinical trials were reviewed to incorporate the most robust evidence-based literature available. A total of 37 publications were narrowed down based upon the topic. Alterations in brain neuroplasticity, as evidenced by changes in neurotrophic factors and from neuroimaging, has been found to be a strong patho-mechanism for MDD. This link has been exploited to stimulate psychopharmacological research to treat MDD | ||
| 650 | 4 | |a Review | |
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Nerve Growth Factors |2 NLM | |
| 700 | 1 | |a Nath, Santanu |e verfasserin |4 aut | |
| 700 | 1 | |a Chaturvedi, Jitender |e verfasserin |4 aut | |
| 700 | 1 | |a Sharma, Suresh Kumar |e verfasserin |4 aut | |
| 700 | 1 | |a Joshi, Jaydeep |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Psychiatria Danubina |d 1997 |g 34(2022), 3 vom: 14., Seite 390-397 |w (DE-627)NLM09368309X |x 0353-5053 |7 nnns |
| 773 | 1 | 8 | |g volume:34 |g year:2022 |g number:3 |g day:14 |g pages:390-397 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.24869/psyd.2022.390 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 34 |j 2022 |e 3 |b 14 |h 390-397 | ||