Approaches to investigating metabolism in human neurodevelopment using organoids : insights from intestinal and cancer studies
© 2022. Published by The Company of Biologists Ltd..
Interrogating the impact of metabolism during development is important for understanding cellular and tissue formation, organ and systemic homeostasis, and dysregulation in disease states. To evaluate the vital functions metabolism coordinates during human brain development and disease, pluripotent stem cell-derived models, such as organoids, provide tractable access to neurodevelopmental processes. Despite many strengths of neural organoid models, the extent of their replication of endogenous metabolic programs is currently unclear and requires direct investigation. Studies in intestinal and cancer organoids that functionally evaluate dynamic bioenergetic changes provide a framework that can be adapted for the study of neural metabolism. Validation of in vitro models remains a significant challenge; investigation using in vivo models and primary tissue samples is required to improve our in vitro model systems and, concomitantly, improve our understanding of human development.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2022 |
|---|---|
| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:149 |
|---|---|
| Enthalten in: |
Development (Cambridge, England) - 149(2022), 20 vom: 15. Okt. |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Morales, Alexandria [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
In vitro models |
|---|
| Anmerkungen: |
Date Completed 20.10.2022 Date Revised 19.10.2023 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1242/dev.200506 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM347702147 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM347702147 | ||
| 003 | DE-627 | ||
| 005 | 20231226034445.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1242/dev.200506 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1158.xml |
| 035 | |a (DE-627)NLM347702147 | ||
| 035 | |a (NLM)36255366 | ||
| 035 | |a (PII)dev200506 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Morales, Alexandria |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Approaches to investigating metabolism in human neurodevelopment using organoids |b insights from intestinal and cancer studies |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 20.10.2022 | ||
| 500 | |a Date Revised 19.10.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2022. Published by The Company of Biologists Ltd. | ||
| 520 | |a Interrogating the impact of metabolism during development is important for understanding cellular and tissue formation, organ and systemic homeostasis, and dysregulation in disease states. To evaluate the vital functions metabolism coordinates during human brain development and disease, pluripotent stem cell-derived models, such as organoids, provide tractable access to neurodevelopmental processes. Despite many strengths of neural organoid models, the extent of their replication of endogenous metabolic programs is currently unclear and requires direct investigation. Studies in intestinal and cancer organoids that functionally evaluate dynamic bioenergetic changes provide a framework that can be adapted for the study of neural metabolism. Validation of in vitro models remains a significant challenge; investigation using in vivo models and primary tissue samples is required to improve our in vitro model systems and, concomitantly, improve our understanding of human development | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a In vitro models | |
| 650 | 4 | |a Metabolism | |
| 650 | 4 | |a Neural development | |
| 650 | 4 | |a Organoids | |
| 700 | 1 | |a Andrews, Madeline G |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Development (Cambridge, England) |d 1987 |g 149(2022), 20 vom: 15. Okt. |w (DE-627)NLM01260755X |x 1477-9129 |7 nnns |
| 773 | 1 | 8 | |g volume:149 |g year:2022 |g number:20 |g day:15 |g month:10 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1242/dev.200506 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 149 |j 2022 |e 20 |b 15 |c 10 | ||