Curcumin-based ionic Pt(II) complexes : antioxidant and antimicrobial activity
A series of novel cationic curcumin-based Pt(II) complexes with neutral (N^N) ligands and triflate anions as counterions, [(N^N)Pt(curc)]CF3SO3, 1-4, were synthesised and fully characterised. The antioxidant radical scavenging activity of complexes 1-4 was measured spectrophotometrically using DPPH as the internal probe. Computational strategies have been exploited to ascertain the mechanism of antioxidant action of curcumin (H(curc)) and its Pt(II) complexes. Finally, compounds 1-4 were tested in vitro for their growth inhibitory activity against two bacteria (Staphylococcus aureus and Escherichia coli) by the disk diffusion technique at different Pt(II) complex solution concentrations. The effect of the complexation of H(curc) was investigated.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:51 |
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| Enthalten in: |
Dalton transactions (Cambridge, England : 2003) - 51(2022), 43 vom: 08. Nov., Seite 16545-16556 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Caligiuri, Rossella [VerfasserIn] |
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| Links: |
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| Themen: |
Anti-Infective Agents |
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| Anmerkungen: |
Date Completed 09.11.2022 Date Revised 09.11.2022 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1039/d2dt01653b |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM347698328 |
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| 520 | |a A series of novel cationic curcumin-based Pt(II) complexes with neutral (N^N) ligands and triflate anions as counterions, [(N^N)Pt(curc)]CF3SO3, 1-4, were synthesised and fully characterised. The antioxidant radical scavenging activity of complexes 1-4 was measured spectrophotometrically using DPPH as the internal probe. Computational strategies have been exploited to ascertain the mechanism of antioxidant action of curcumin (H(curc)) and its Pt(II) complexes. Finally, compounds 1-4 were tested in vitro for their growth inhibitory activity against two bacteria (Staphylococcus aureus and Escherichia coli) by the disk diffusion technique at different Pt(II) complex solution concentrations. The effect of the complexation of H(curc) was investigated | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Scarpelli, Francesca |e verfasserin |4 aut | |
| 700 | 1 | |a Candreva, Angela |e verfasserin |4 aut | |
| 700 | 1 | |a Rimoldi, Isabella |e verfasserin |4 aut | |
| 700 | 1 | |a Facchetti, Giorgio |e verfasserin |4 aut | |
| 700 | 1 | |a Lupo, Maria Giovanna |e verfasserin |4 aut | |
| 700 | 1 | |a Sicilia, Emilia |e verfasserin |4 aut | |
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| 700 | 1 | |a Ponte, Fortuna |e verfasserin |4 aut | |
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| 700 | 1 | |a De Rose, Renata |e verfasserin |4 aut | |
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