Comparative efficacy and safety of pharmacological interventions for severe COVID-19 patients : An updated network meta-analysis of 48 randomized controlled trials
Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc..
BACKGROUND: To date, there has been little agreement on what drug is the "best" drug for treating severe COVID-19 patients. This study aimed to assess the efficacy and safety of different medications available at present for severe COVID-19.
METHODS: We searched databases for randomized controlled trials (RCTs) published up to February 28, 2022, with no language restrictions, of medications recommended for patients (aged 16 years or older) with severe COVID-19 infection. We extracted data on trials and patient characteristics, and the following primary outcomes: all-cause mortality (ACM), and treatment-emergent adverse events (TEAEs).
RESULTS: We identified 4021 abstracts and of these included 48 RCTs comprising 9147 participants through database searches and other sources. For decrease in ACM, we found that ivermectin/doxycycline, C-IVIG (i.e., a hyperimmune anti-COVID-19 intravenous immunoglobulin), methylprednisolone, interferon-beta/standard-of-care (SOC), interferon-beta-1b, convalescent plasma, remdesivir, lopinavir/ritonavir, immunoglobulin gamma, high dosage sarilumab (HS), auxora, and imatinib were effective when compared with placebo or SOC group. We found that colchicine and interferon-beta/SOC were only associated with the TEAEs of severe COVID-19 patients.
CONCLUSION: This study suggested that ivermectin/doxycycline, C-IVIG, methylprednisolone, interferon-beta/SOC, interferon-beta-1b, convalescent plasma (CP), remdesivir, lopinavir/ritonavir, immunoglobulin gamma, HS, auxora, and imatinib were efficacious for treating severe COVID-19 patients. We found that most medications were safe in treating severe COVID-19. More large-scale RCTs are still needed to confirm the results of this study.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:101 |
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| Enthalten in: |
Medicine - 101(2022), 41 vom: 14. Okt., Seite e30998 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Cheng, Qinglin [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 19.10.2022 Date Revised 07.12.2022 published: Print Citation Status MEDLINE |
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| doi: |
10.1097/MD.0000000000030998 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM347689663 |
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| 100 | 1 | |a Cheng, Qinglin |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Comparative efficacy and safety of pharmacological interventions for severe COVID-19 patients |b An updated network meta-analysis of 48 randomized controlled trials |
| 264 | 1 | |c 2022 | |
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| 500 | |a Date Completed 19.10.2022 | ||
| 500 | |a Date Revised 07.12.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. | ||
| 520 | |a BACKGROUND: To date, there has been little agreement on what drug is the "best" drug for treating severe COVID-19 patients. This study aimed to assess the efficacy and safety of different medications available at present for severe COVID-19 | ||
| 520 | |a METHODS: We searched databases for randomized controlled trials (RCTs) published up to February 28, 2022, with no language restrictions, of medications recommended for patients (aged 16 years or older) with severe COVID-19 infection. We extracted data on trials and patient characteristics, and the following primary outcomes: all-cause mortality (ACM), and treatment-emergent adverse events (TEAEs) | ||
| 520 | |a RESULTS: We identified 4021 abstracts and of these included 48 RCTs comprising 9147 participants through database searches and other sources. For decrease in ACM, we found that ivermectin/doxycycline, C-IVIG (i.e., a hyperimmune anti-COVID-19 intravenous immunoglobulin), methylprednisolone, interferon-beta/standard-of-care (SOC), interferon-beta-1b, convalescent plasma, remdesivir, lopinavir/ritonavir, immunoglobulin gamma, high dosage sarilumab (HS), auxora, and imatinib were effective when compared with placebo or SOC group. We found that colchicine and interferon-beta/SOC were only associated with the TEAEs of severe COVID-19 patients | ||
| 520 | |a CONCLUSION: This study suggested that ivermectin/doxycycline, C-IVIG, methylprednisolone, interferon-beta/SOC, interferon-beta-1b, convalescent plasma (CP), remdesivir, lopinavir/ritonavir, immunoglobulin gamma, HS, auxora, and imatinib were efficacious for treating severe COVID-19 patients. We found that most medications were safe in treating severe COVID-19. More large-scale RCTs are still needed to confirm the results of this study | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Meta-Analysis | |
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| 650 | 7 | |a Interferon beta-1b |2 NLM | |
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| 650 | 7 | |a Ivermectin |2 NLM | |
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| 650 | 7 | |a Imatinib Mesylate |2 NLM | |
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| 650 | 7 | |a Doxycycline |2 NLM | |
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| 700 | 1 | |a Zhao, Gang |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Junfang |e verfasserin |4 aut | |
| 700 | 1 | |a Jia, Qingjun |e verfasserin |4 aut | |
| 700 | 1 | |a Fang, Zijian |e verfasserin |4 aut | |
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