Enhanced mechanical properties, anti-biofilm activity, and cytocompatibility of a methacrylate-based polymer loaded with native multiwalled carbon nanotubes
Copyright © 2022 Elsevier Ltd. All rights reserved..
OBJECTIVES: We aimed to optimize the mechanical and biological properties of a conventional methacrylate-based dental polymer by loading it with double- and triple-walled carbon nanotubes as growth (DTWCNTG).
METHODS: A formulation of bisphenol A-glycidyl methacrylate and triethylene glycol dimethacrylate (mass ratio = 2:1) was mixed with DTWCNTG at concentrations of 0.0% (control), 0.001%, 0.005%, and 0.010%. The concentrations were physicochemical and morphologically evaluated, and antibacterial activity was assessed by seeding a Streptococcus mutans strain (ATCC 25175) on the experimental polymeric surfaces. Cellular survival and osteodifferentiation were evaluated in epithelial (HaCat) and preosteoblast cells (MC3T3-E1).
RESULTS: The 0.001% DTWCNTG concentration yielded higher compressive strength, elastic modulus, flexural strength, flexural modulus, water sorption, and solubility than the control. The degree of conversion and color did not significantly change with a low amount of DTWCNTG incorporated into the polymer. Antibacterial activity significantly improved when tested on the 0.001% DTWCNTG discs. No groups showed cytotoxicity in a short-term analysis and adding DTWCNTG favored MC3T3-E1 mineralization over the control, particularly in the 0.001% formulation.
SIGNIFICANCE: The micro-addition of 0.001% DTWCNTG confers mechanical resistance, antimicrobial properties, and bioactivity to methacrylate-based polymers without significantly compromising color. Incorporating DTWCNTG improved dental composite properties and could be a biomodified material for minimally invasive procedures.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:136 |
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| Enthalten in: |
Journal of the mechanical behavior of biomedical materials - 136(2022) vom: 22. Dez., Seite 105511 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Rodrigues, Ricardo Antonio Alpino [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 23.10.2023 Date Revised 24.10.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.jmbbm.2022.105511 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM347673260 |
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| 041 | |a eng | ||
| 100 | 1 | |a Rodrigues, Ricardo Antonio Alpino |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Enhanced mechanical properties, anti-biofilm activity, and cytocompatibility of a methacrylate-based polymer loaded with native multiwalled carbon nanotubes |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
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| 500 | |a Date Completed 23.10.2023 | ||
| 500 | |a Date Revised 24.10.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2022 Elsevier Ltd. All rights reserved. | ||
| 520 | |a OBJECTIVES: We aimed to optimize the mechanical and biological properties of a conventional methacrylate-based dental polymer by loading it with double- and triple-walled carbon nanotubes as growth (DTWCNTG) | ||
| 520 | |a METHODS: A formulation of bisphenol A-glycidyl methacrylate and triethylene glycol dimethacrylate (mass ratio = 2:1) was mixed with DTWCNTG at concentrations of 0.0% (control), 0.001%, 0.005%, and 0.010%. The concentrations were physicochemical and morphologically evaluated, and antibacterial activity was assessed by seeding a Streptococcus mutans strain (ATCC 25175) on the experimental polymeric surfaces. Cellular survival and osteodifferentiation were evaluated in epithelial (HaCat) and preosteoblast cells (MC3T3-E1) | ||
| 520 | |a RESULTS: The 0.001% DTWCNTG concentration yielded higher compressive strength, elastic modulus, flexural strength, flexural modulus, water sorption, and solubility than the control. The degree of conversion and color did not significantly change with a low amount of DTWCNTG incorporated into the polymer. Antibacterial activity significantly improved when tested on the 0.001% DTWCNTG discs. No groups showed cytotoxicity in a short-term analysis and adding DTWCNTG favored MC3T3-E1 mineralization over the control, particularly in the 0.001% formulation | ||
| 520 | |a SIGNIFICANCE: The micro-addition of 0.001% DTWCNTG confers mechanical resistance, antimicrobial properties, and bioactivity to methacrylate-based polymers without significantly compromising color. Incorporating DTWCNTG improved dental composite properties and could be a biomodified material for minimally invasive procedures | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Antibacterial activity | |
| 650 | 4 | |a Biomodification | |
| 650 | 4 | |a Dental resin composites | |
| 650 | 4 | |a Methacrylate-based polymers | |
| 650 | 4 | |a Multiwalled carbon nanotubes | |
| 650 | 7 | |a Methacrylates |2 NLM | |
| 650 | 7 | |a Nanotubes, Carbon |2 NLM | |
| 650 | 7 | |a Composite Resins |2 NLM | |
| 650 | 7 | |a Polymers |2 NLM | |
| 650 | 7 | |a Bisphenol A-Glycidyl Methacrylate |2 NLM | |
| 650 | 7 | |a 454I75YXY0 |2 NLM | |
| 650 | 7 | |a Polymethacrylic Acids |2 NLM | |
| 650 | 7 | |a Polyethylene Glycols |2 NLM | |
| 650 | 7 | |a 3WJQ0SDW1A |2 NLM | |
| 650 | 7 | |a Anti-Bacterial Agents |2 NLM | |
| 700 | 1 | |a Silva, Rosangela Maria Ferreira da Costa E |e verfasserin |4 aut | |
| 700 | 1 | |a Ferreira, Luiza de Almeida Queiroz |e verfasserin |4 aut | |
| 700 | 1 | |a Branco, Natália Tavares Teixeira |e verfasserin |4 aut | |
| 700 | 1 | |a Ávila, Érick de Souza |e verfasserin |4 aut | |
| 700 | 1 | |a Peres, Anderson Maia |e verfasserin |4 aut | |
| 700 | 1 | |a Fernandes-Braga, Weslley |e verfasserin |4 aut | |
| 700 | 1 | |a Sette-Dias, Augusto César |e verfasserin |4 aut | |
| 700 | 1 | |a Andrade, Ângela Leão |e verfasserin |4 aut | |
| 700 | 1 | |a Palma-Dibb, Regina Guenka |e verfasserin |4 aut | |
| 700 | 1 | |a Magalhães, Cláudia Silami de |e verfasserin |4 aut | |
| 700 | 1 | |a Ladeira, Luiz Orlando |e verfasserin |4 aut | |
| 700 | 1 | |a Silveira, Rodrigo Richard da |e verfasserin |4 aut | |
| 700 | 1 | |a Moreira, Allyson Nogueira |e verfasserin |4 aut | |
| 700 | 1 | |a Martins Júnior, Paulo Antônio |e verfasserin |4 aut | |
| 700 | 1 | |a Yamauti, Mônica |e verfasserin |4 aut | |
| 700 | 1 | |a Diniz, Ivana Márcia Alves |e verfasserin |4 aut | |
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