Improvement of ascorbic acid delivery into human skin via hyaluronic acid-coated niosomes
Hyaluronic acid (HA) as a covering agent was incorporated into the ascorbic acid (AA)-niosomes to improve the performance of AA delivery systems into the skin. The preparation method: Thin film hydration. Characterisation tests: Field emission scanning electron microscopy, fourier transform infra-red spectroscopy, dynamic light scattering, UV-Visible, zeta potential, Franz diffusion cell, and flowcytometry. The niosomes with 10% w/w HA possessed the largest mean particle diameter of 341.0 ± 48.09 nm with PDI value of 0.29 ± 0.05, and the lowest zeta potential of -38.70 ± 0.27 mv. The drug encapsulation efficiency of this sample was 56.55 ± 0.99%, and in-vitro drug release test showed AA released in two slow and fast phases. Moreover, the highest amount of drug penetration and accumulation was related to this sample, recorded 116.55 ± 7.54 and 134.8 ± 10.04 µg/cm2, respectively. Niosomes coated with 10% w/w HA showed the greatest potential for improving the antioxidant activity of AA penetration into the skin.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:39 |
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| Enthalten in: |
Journal of microencapsulation - 39(2022), 6 vom: 01. Sept., Seite 552-562 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Shabani Dargah, Motahareh [VerfasserIn] |
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| Links: |
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| Themen: |
9004-61-9 |
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| Anmerkungen: |
Date Completed 28.12.2022 Date Revised 03.01.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1080/02652048.2022.2135783 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM347668712 |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Hyaluronic acid (HA) as a covering agent was incorporated into the ascorbic acid (AA)-niosomes to improve the performance of AA delivery systems into the skin. The preparation method: Thin film hydration. Characterisation tests: Field emission scanning electron microscopy, fourier transform infra-red spectroscopy, dynamic light scattering, UV-Visible, zeta potential, Franz diffusion cell, and flowcytometry. The niosomes with 10% w/w HA possessed the largest mean particle diameter of 341.0 ± 48.09 nm with PDI value of 0.29 ± 0.05, and the lowest zeta potential of -38.70 ± 0.27 mv. The drug encapsulation efficiency of this sample was 56.55 ± 0.99%, and in-vitro drug release test showed AA released in two slow and fast phases. Moreover, the highest amount of drug penetration and accumulation was related to this sample, recorded 116.55 ± 7.54 and 134.8 ± 10.04 µg/cm2, respectively. Niosomes coated with 10% w/w HA showed the greatest potential for improving the antioxidant activity of AA penetration into the skin | ||
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