Emerging role of IκBζ in inflammation : Emphasis on psoriasis
© 2022 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics..
Psoriasis is a chronic inflammatory disorder affecting skin and joints that results from immunological dysfunction such as enhanced IL-23 induced Th-17 differentiation. IkappaB-Zeta (IκBζ) is an atypical transcriptional factor of the IκB protein family since, contrary to the other family members, it positively regulates NF-κB pathway by being exclusively localized into the nucleus. IκBζ deficiency reduces visible manifestations of experimental psoriasis by diminishing expression of psoriasis-associated genes. It is thus tempting to consider IκBζ as a potential therapeutic target for psoriasis as well as for other IL23/IL17-mediated inflammatory diseases. In this review, we will discuss the regulation of expression of NFKBIZ and its protein IκBζ, its downstream targets, its involvement in pathogenesis of multiple disorders with emphasis on psoriasis and evidences supporting that inhibition of IκBζ may be a promising alternative to current therapeutic managements of psoriasis.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
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| Enthalten in: |
Clinical and translational medicine - 12(2022), 10 vom: 16. Okt., Seite e1032 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Gautam, Preeti [VerfasserIn] |
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| Links: |
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| Themen: |
I-kappa B Proteins |
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| Anmerkungen: |
Date Completed 21.10.2022 Date Revised 26.01.2023 published: Print Citation Status MEDLINE |
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| doi: |
10.1002/ctm2.1032 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM347602614 |
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| 520 | |a © 2022 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics. | ||
| 520 | |a Psoriasis is a chronic inflammatory disorder affecting skin and joints that results from immunological dysfunction such as enhanced IL-23 induced Th-17 differentiation. IkappaB-Zeta (IκBζ) is an atypical transcriptional factor of the IκB protein family since, contrary to the other family members, it positively regulates NF-κB pathway by being exclusively localized into the nucleus. IκBζ deficiency reduces visible manifestations of experimental psoriasis by diminishing expression of psoriasis-associated genes. It is thus tempting to consider IκBζ as a potential therapeutic target for psoriasis as well as for other IL23/IL17-mediated inflammatory diseases. In this review, we will discuss the regulation of expression of NFKBIZ and its protein IκBζ, its downstream targets, its involvement in pathogenesis of multiple disorders with emphasis on psoriasis and evidences supporting that inhibition of IκBζ may be a promising alternative to current therapeutic managements of psoriasis | ||
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| 700 | 1 | |a Cailotto, Frédéric |e verfasserin |4 aut | |
| 700 | 1 | |a Reboul, Pascal |e verfasserin |4 aut | |
| 700 | 1 | |a Labialle, Stéphane |e verfasserin |4 aut | |
| 700 | 1 | |a Jouzeau, Jean-Yves |e verfasserin |4 aut | |
| 700 | 1 | |a Bourgaud, Frédéric |e verfasserin |4 aut | |
| 700 | 1 | |a Moulin, David |e verfasserin |4 aut | |
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