A sePARate phase? Poly(ADP-ribose) versus RNA in the organization of biomolecular condensates
© The Author(s) 2022. Published by Oxford University Press on behalf of Nucleic Acids Research..
Condensates are biomolecular assemblies that concentrate biomolecules without the help of membranes. They are morphologically highly versatile and may emerge via distinct mechanisms. Nucleic acids-DNA, RNA and poly(ADP-ribose) (PAR) play special roles in the process of condensate organization. These polymeric scaffolds provide multiple specific and nonspecific interactions during nucleation and 'development' of macromolecular assemblages. In this review, we focus on condensates formed with PAR. We discuss to what extent the literature supports the phase separation origin of these structures. Special attention is paid to similarities and differences between PAR and RNA in the process of dynamic restructuring of condensates during their functioning.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2022 |
|---|---|
| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:50 |
|---|---|
| Enthalten in: |
Nucleic acids research - 50(2022), 19 vom: 28. Okt., Seite 10817-10838 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Alemasova, Elizaveta E [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
26656-46-2 |
|---|
| Anmerkungen: |
Date Completed 08.11.2022 Date Revised 10.11.2022 published: Print Citation Status MEDLINE |
|---|
| doi: |
10.1093/nar/gkac866 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM347589634 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM347589634 | ||
| 003 | DE-627 | ||
| 005 | 20231226034204.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1093/nar/gkac866 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1158.xml |
| 035 | |a (DE-627)NLM347589634 | ||
| 035 | |a (NLM)36243979 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Alemasova, Elizaveta E |e verfasserin |4 aut | |
| 245 | 1 | 2 | |a A sePARate phase? Poly(ADP-ribose) versus RNA in the organization of biomolecular condensates |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 08.11.2022 | ||
| 500 | |a Date Revised 10.11.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © The Author(s) 2022. Published by Oxford University Press on behalf of Nucleic Acids Research. | ||
| 520 | |a Condensates are biomolecular assemblies that concentrate biomolecules without the help of membranes. They are morphologically highly versatile and may emerge via distinct mechanisms. Nucleic acids-DNA, RNA and poly(ADP-ribose) (PAR) play special roles in the process of condensate organization. These polymeric scaffolds provide multiple specific and nonspecific interactions during nucleation and 'development' of macromolecular assemblages. In this review, we focus on condensates formed with PAR. We discuss to what extent the literature supports the phase separation origin of these structures. Special attention is paid to similarities and differences between PAR and RNA in the process of dynamic restructuring of condensates during their functioning | ||
| 650 | 4 | |a Review | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Poly Adenosine Diphosphate Ribose |2 NLM | |
| 650 | 7 | |a 26656-46-2 |2 NLM | |
| 650 | 7 | |a RNA |2 NLM | |
| 650 | 7 | |a 63231-63-0 |2 NLM | |
| 650 | 7 | |a Macromolecular Substances |2 NLM | |
| 650 | 7 | |a Nucleic Acids |2 NLM | |
| 700 | 1 | |a Lavrik, Olga I |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Nucleic acids research |d 1974 |g 50(2022), 19 vom: 28. Okt., Seite 10817-10838 |w (DE-627)NLM000063398 |x 1362-4962 |7 nnns |
| 773 | 1 | 8 | |g volume:50 |g year:2022 |g number:19 |g day:28 |g month:10 |g pages:10817-10838 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1093/nar/gkac866 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 50 |j 2022 |e 19 |b 28 |c 10 |h 10817-10838 | ||