Serum concentrations of ketones increase after hand-ergometer exercise in persons with cervical spinal cord injuries : a preliminary prospective study
© 2022. The Author(s), under exclusive licence to International Spinal Cord Society..
STUDY DESIGN: Experimental study.
OBJECTIVES: To compare lipid profiles during moderate-intensity exercise between persons with cervical spinal cord injuries (SCIC) and able-bodied controls (AB).
SETTING: Wakayama Medical University, Japan.
METHODS: Six participants with SCIC and six AB performed 30-min arm-crank exercise at 50% VO2peak. Blood samples were collected before (PRE), immediately (POST), and 60 min after exercise (REC). Concentrations of serum free fatty acids ([FFA]s), total ketone bodies ([tKB]s), acetoacetic acid ([AcAc]s), insulin ([Ins]s), and plasma catecholamines and glucose ([Glc]p) were assessed.
RESULTS: Catecholamine concentrations in SCIC were lower than AB throughout the experiment (P < 0.001) and remained unchanged, while increased at POST in AB (P < 0.01). [FFA]s remained unchanged in both groups with no differences between groups. [tKB]s in SCIC tended to increase at REC from PRE (P = 0.043), while remaining unchanged in AB (P > 0.42). [AcAc]s in SCIC increased at REC from PRE and POST (P < 0.01) while remaining unchanged in AB (interactions of Group × Time P = 0.014). [Glc]p and [Ins]s were comparable between the groups throughout the study.
CONCLUSION: Serum ketone bodies in SCIC increased after exercise while remaining unchanged in AB, suggesting that suppressed uptakes of serum ketone bodies from blood to the muscles in SCIC would partially contribute the increased serum ketones.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:61 |
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| Enthalten in: |
Spinal cord - 61(2023), 2 vom: 14. Feb., Seite 139-144 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Nishiyama, Kazunari [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 01.03.2023 Date Revised 09.03.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1038/s41393-022-00859-x |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM347567223 |
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| 100 | 1 | |a Nishiyama, Kazunari |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Serum concentrations of ketones increase after hand-ergometer exercise in persons with cervical spinal cord injuries |b a preliminary prospective study |
| 264 | 1 | |c 2023 | |
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| 500 | |a Date Completed 01.03.2023 | ||
| 500 | |a Date Revised 09.03.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2022. The Author(s), under exclusive licence to International Spinal Cord Society. | ||
| 520 | |a STUDY DESIGN: Experimental study | ||
| 520 | |a OBJECTIVES: To compare lipid profiles during moderate-intensity exercise between persons with cervical spinal cord injuries (SCIC) and able-bodied controls (AB) | ||
| 520 | |a SETTING: Wakayama Medical University, Japan | ||
| 520 | |a METHODS: Six participants with SCIC and six AB performed 30-min arm-crank exercise at 50% VO2peak. Blood samples were collected before (PRE), immediately (POST), and 60 min after exercise (REC). Concentrations of serum free fatty acids ([FFA]s), total ketone bodies ([tKB]s), acetoacetic acid ([AcAc]s), insulin ([Ins]s), and plasma catecholamines and glucose ([Glc]p) were assessed | ||
| 520 | |a RESULTS: Catecholamine concentrations in SCIC were lower than AB throughout the experiment (P < 0.001) and remained unchanged, while increased at POST in AB (P < 0.01). [FFA]s remained unchanged in both groups with no differences between groups. [tKB]s in SCIC tended to increase at REC from PRE (P = 0.043), while remaining unchanged in AB (P > 0.42). [AcAc]s in SCIC increased at REC from PRE and POST (P < 0.01) while remaining unchanged in AB (interactions of Group × Time P = 0.014). [Glc]p and [Ins]s were comparable between the groups throughout the study | ||
| 520 | |a CONCLUSION: Serum ketone bodies in SCIC increased after exercise while remaining unchanged in AB, suggesting that suppressed uptakes of serum ketone bodies from blood to the muscles in SCIC would partially contribute the increased serum ketones | ||
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Ketones |2 NLM | |
| 650 | 7 | |a Ketone Bodies |2 NLM | |
| 650 | 7 | |a Catecholamines |2 NLM | |
| 700 | 1 | |a Nishimuara, Yukihide |e verfasserin |4 aut | |
| 700 | 1 | |a Au, Jason S |e verfasserin |4 aut | |
| 700 | 1 | |a Kamijo, Yoshi-Ichiro |e verfasserin |4 aut | |
| 700 | 1 | |a Moriki, Takashi |e verfasserin |4 aut | |
| 700 | 1 | |a Mukai, Yuki |e verfasserin |4 aut | |
| 700 | 1 | |a Umemoto, Yasunori |e verfasserin |4 aut | |
| 700 | 1 | |a Kouda, Ken |e verfasserin |4 aut | |
| 700 | 1 | |a Ogawa, Takahiro |e verfasserin |4 aut | |
| 700 | 1 | |a Tajima, Fumihiro |e verfasserin |4 aut | |
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