Systemic sclerosis-associated interstitial lung disease in the EUSTAR database : analysis by region
© The Author(s) 2022. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissionsoup.com..
OBJECTIVES: The prevalence and characteristics of SSc-associated interstitial lung disease (SSc-ILD) vary between geographical regions worldwide. The objectives of this study were to explore the differences in terms of prevalence, phenotype, treatment and prognosis in patients with SSc-ILD from predetermined geographical regions in the EUSTAR database.
MATERIAL AND METHODS: Patients were clustered into seven geographical regions. Clinical characteristics and survival of patients with SSc-ILD were compared among these pre-determined regions.
RESULTS: For baseline analyses, 9260 SSc patients were included, with 6732 for survival analyses. The prevalence of SSc-ILD in the overall population was 50.2%, ranging from 44.0% in 'Western Europe and Nordic countries' to 67.5% in 'Eastern European, Russia and Baltic countries'. In all regions, anti-topoisomerase antibodies were associated with SSc-ILD. Management also significantly differed; mycophenolate mofetil was prescribed at baseline in 31.6% of patients with SSc-ILD in 'America (North and South)' and 31.7% in 'Middle East' but only 4.3% in 'Asia and Oceania' (P <0.0001). Patients from 'America (North and South)' and 'Middle East' had the highest survival rate at the end of follow-up (85.8% and 85.2%, respectively).
CONCLUSIONS: Our study highlights key differences among regions in terms of clinical presentation and prognosis of SSc-ILD. This work also demonstrates that the management of SSc-ILD is highly variable among the different regions considered, suggesting that efforts are still needed for the standardization of medical practice in the treatment of this disease.
| Errataetall: |
ErratumIn: Rheumatology (Oxford). 2023 Sep 1;62(9):3219-3220. - PMID 37295958 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:62 |
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| Enthalten in: |
Rheumatology (Oxford, England) - 62(2023), 6 vom: 01. Juni, Seite 2178-2188 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Lescoat, Alain [VerfasserIn] |
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| Links: |
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| Themen: |
Autoantibodies |
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| Anmerkungen: |
Date Completed 05.06.2023 Date Revised 09.06.2023 published: Print ErratumIn: Rheumatology (Oxford). 2023 Sep 1;62(9):3219-3220. - PMID 37295958 Citation Status MEDLINE |
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| doi: |
10.1093/rheumatology/keac576 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 100 | 1 | |a Lescoat, Alain |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Systemic sclerosis-associated interstitial lung disease in the EUSTAR database |b analysis by region |
| 264 | 1 | |c 2023 | |
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| 500 | |a Date Completed 05.06.2023 | ||
| 500 | |a Date Revised 09.06.2023 | ||
| 500 | |a published: Print | ||
| 500 | |a ErratumIn: Rheumatology (Oxford). 2023 Sep 1;62(9):3219-3220. - PMID 37295958 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © The Author(s) 2022. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissionsoup.com. | ||
| 520 | |a OBJECTIVES: The prevalence and characteristics of SSc-associated interstitial lung disease (SSc-ILD) vary between geographical regions worldwide. The objectives of this study were to explore the differences in terms of prevalence, phenotype, treatment and prognosis in patients with SSc-ILD from predetermined geographical regions in the EUSTAR database | ||
| 520 | |a MATERIAL AND METHODS: Patients were clustered into seven geographical regions. Clinical characteristics and survival of patients with SSc-ILD were compared among these pre-determined regions | ||
| 520 | |a RESULTS: For baseline analyses, 9260 SSc patients were included, with 6732 for survival analyses. The prevalence of SSc-ILD in the overall population was 50.2%, ranging from 44.0% in 'Western Europe and Nordic countries' to 67.5% in 'Eastern European, Russia and Baltic countries'. In all regions, anti-topoisomerase antibodies were associated with SSc-ILD. Management also significantly differed; mycophenolate mofetil was prescribed at baseline in 31.6% of patients with SSc-ILD in 'America (North and South)' and 31.7% in 'Middle East' but only 4.3% in 'Asia and Oceania' (P <0.0001). Patients from 'America (North and South)' and 'Middle East' had the highest survival rate at the end of follow-up (85.8% and 85.2%, respectively) | ||
| 520 | |a CONCLUSIONS: Our study highlights key differences among regions in terms of clinical presentation and prognosis of SSc-ILD. This work also demonstrates that the management of SSc-ILD is highly variable among the different regions considered, suggesting that efforts are still needed for the standardization of medical practice in the treatment of this disease | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a SSc | |
| 650 | 4 | |a autoantibodies | |
| 650 | 4 | |a interstitial lung disease | |
| 650 | 4 | |a lung fibrosis | |
| 650 | 4 | |a scleroderma | |
| 650 | 7 | |a Mycophenolic Acid |2 NLM | |
| 650 | 7 | |a HU9DX48N0T |2 NLM | |
| 700 | 1 | |a Huscher, Dörte |e verfasserin |4 aut | |
| 700 | 1 | |a Schoof, Nils |e verfasserin |4 aut | |
| 700 | 1 | |a Airò, Paolo |e verfasserin |4 aut | |
| 700 | 1 | |a de Vries-Bouwstra, Jeska |e verfasserin |4 aut | |
| 700 | 1 | |a Riemekasten, Gabriela |e verfasserin |4 aut | |
| 700 | 1 | |a Hachulla, Eric |e verfasserin |4 aut | |
| 700 | 1 | |a Doria, Andrea |e verfasserin |4 aut | |
| 700 | 1 | |a Rosato, Edoardo |e verfasserin |4 aut | |
| 700 | 1 | |a Hunzelmann, Nicolas |e verfasserin |4 aut | |
| 700 | 1 | |a Montecucco, Carlomaurizio |e verfasserin |4 aut | |
| 700 | 1 | |a Gabrielli, Armando |e verfasserin |4 aut | |
| 700 | 1 | |a Hoffmann-Vold, Anna-Maria |e verfasserin |4 aut | |
| 700 | 1 | |a Distler, Oliver |e verfasserin |4 aut | |
| 700 | 1 | |a Ben Shimol, Jennifer |e verfasserin |4 aut | |
| 700 | 1 | |a Cutolo, Maurizio |e verfasserin |4 aut | |
| 700 | 1 | |a Allanore, Yannick |e verfasserin |4 aut | |
| 700 | 0 | |a EUSTAR collaborators |e verfasserin |4 aut | |
| 700 | 1 | |a Cerinic, Marco Matucci |e investigator |4 oth | |
| 700 | 1 | |a Walker, Ulrich |e investigator |4 oth | |
| 700 | 1 | |a Iannone, Florenzo |e investigator |4 oth | |
| 700 | 1 | |a Becvar, Radim |e investigator |4 oth | |
| 700 | 1 | |a Bielecka, Otylia Kowal |e investigator |4 oth | |
| 700 | 1 | |a Pizzorni, Carmen |e investigator |4 oth | |
| 700 | 1 | |a Ciccia, Francesco |e investigator |4 oth | |
| 700 | 1 | |a Siegert, Elise |e investigator |4 oth | |
| 700 | 1 | |a Rednic, Simona |e investigator |4 oth | |
| 700 | 1 | |a Vlachoyiannopoulos, P |e investigator |4 oth | |
| 700 | 1 | |a Stork, Jiri |e investigator |4 oth | |
| 700 | 1 | |a Inanc, Murat |e investigator |4 oth | |
| 700 | 1 | |a Carreira, Patricia E |e investigator |4 oth | |
| 700 | 1 | |a Novak, Srdan |e investigator |4 oth | |
| 700 | 1 | |a Czirják, László |e investigator |4 oth | |
| 700 | 1 | |a Iudici, Michele |e investigator |4 oth | |
| 700 | 1 | |a Kucharz, Eugene J |e investigator |4 oth | |
| 700 | 1 | |a Perdan-Pirkmajer, Katja |e investigator |4 oth | |
| 700 | 1 | |a Coleiro, Bernard |e investigator |4 oth | |
| 700 | 1 | |a Moroncini, Gianluca |e investigator |4 oth | |
| 700 | 1 | |a Bancel, Dominique Farge |e investigator |4 oth | |
| 700 | 1 | |a Mendoza, Fabian A |e investigator |4 oth | |
| 700 | 1 | |a Hesselstrand, Roger |e investigator |4 oth | |
| 700 | 1 | |a Radic, Mislav |e investigator |4 oth | |
| 700 | 1 | |a Balbir-Gurman, Alexandra |e investigator |4 oth | |
| 700 | 1 | |a Monaco, Andrea Lo |e investigator |4 oth | |
| 700 | 1 | |a Pellerito, Raffaele |e investigator |4 oth | |
| 700 | 1 | |a Giollo, Alessandro |e investigator |4 oth | |
| 700 | 1 | |a Morovic-Vergles, Jadranka |e investigator |4 oth | |
| 700 | 1 | |a Denton, Christopher |e investigator |4 oth | |
| 700 | 1 | |a Vonk, Madelon |e investigator |4 oth | |
| 700 | 1 | |a Damjanov, Nemanja |e investigator |4 oth | |
| 700 | 1 | |a Henes, Jörg |e investigator |4 oth | |
| 700 | 1 | |a Santamaria, Vera Ortiz |e investigator |4 oth | |
| 700 | 1 | |a Heitmann, Stefan |e investigator |4 oth | |
| 700 | 1 | |a Krasowska, Dorota |e investigator |4 oth | |
| 700 | 1 | |a Hasler, Paul |e investigator |4 oth | |
| 700 | 1 | |a Kohm, Michaela |e investigator |4 oth | |
| 700 | 1 | |a Foeldvari, Ivan |e investigator |4 oth | |
| 700 | 1 | |a Bajocchi, Gianluigi |e investigator |4 oth | |
| 700 | 1 | |a Salvador, Maria João |e investigator |4 oth | |
| 700 | 1 | |a Stamenkovic, Bojana |e investigator |4 oth | |
| 700 | 1 | |a Selmi, Carlo Francesco |e investigator |4 oth | |
| 700 | 1 | |a Tikly, Mohammed |e investigator |4 oth | |
| 700 | 1 | |a Ananieva, Lidia P |e investigator |4 oth | |
| 700 | 1 | |a Herrick, Ariane |e investigator |4 oth | |
| 700 | 1 | |a Müller-Ladner, Ulf |e investigator |4 oth | |
| 700 | 1 | |a Søndergaard, Klaus |e investigator |4 oth | |
| 700 | 1 | |a Puppo, Francesco |e investigator |4 oth | |
| 700 | 1 | |a Engelhart, Merete |e investigator |4 oth | |
| 700 | 1 | |a Szücs, Gabriela |e investigator |4 oth | |
| 700 | 1 | |a de la Puente, Carlos |e investigator |4 oth | |
| 700 | 1 | |a Riccieri, Valeria |e investigator |4 oth | |
| 700 | 1 | |a Ionescu, Ruxandra Maria |e investigator |4 oth | |
| 700 | 1 | |a Sha, Ami |e investigator |4 oth | |
| 700 | 1 | |a Gheorghiu, Ana Maria |e investigator |4 oth | |
| 700 | 1 | |a Sunderkötter, Cord |e investigator |4 oth | |
| 700 | 1 | |a Distler, Jörg |e investigator |4 oth | |
| 700 | 1 | |a Ingegnoli, Francesca |e investigator |4 oth | |
| 700 | 1 | |a Mouthon, Luc |e investigator |4 oth | |
| 700 | 1 | |a Smith, Vanessa |e investigator |4 oth | |
| 700 | 1 | |a Cantatore, Francesco Paolo |e investigator |4 oth | |
| 700 | 1 | |a Ullman, Susanne |e investigator |4 oth | |
| 700 | 1 | |a von Mühlen, Carlos Alberto |e investigator |4 oth | |
| 700 | 1 | |a Pozzi, Maria Rosa |e investigator |4 oth | |
| 700 | 1 | |a Eyerich, Kilian |e investigator |4 oth | |
| 700 | 1 | |a Wiland, Piotr |e investigator |4 oth | |
| 700 | 1 | |a Vanthuyne, Marie |e investigator |4 oth | |
| 700 | 1 | |a Alegre-Sancho, Juan Jose |e investigator |4 oth | |
| 700 | 1 | |a Herrmann, Kristine |e investigator |4 oth | |
| 700 | 1 | |a De Langhe, Ellen |e investigator |4 oth | |
| 700 | 1 | |a Anic, Branimir |e investigator |4 oth | |
| 700 | 1 | |a Baresic, Marko |e investigator |4 oth | |
| 700 | 1 | |a Mayer, Miroslav |e investigator |4 oth | |
| 700 | 1 | |a Üprus, Maria |e investigator |4 oth | |
| 700 | 1 | |a Otsa, Kati |e investigator |4 oth | |
| 700 | 1 | |a Yavuz, Sule |e investigator |4 oth | |
| 700 | 1 | |a Granel, Brigitte |e investigator |4 oth | |
| 700 | 1 | |a de Souza Müller, Carolina |e investigator |4 oth | |
| 700 | 1 | |a Agachi, Svetlana |e investigator |4 oth | |
| 700 | 1 | |a Stebbings, Simon |e investigator |4 oth | |
| 700 | 1 | |a Mathieu, Alessandro |e investigator |4 oth | |
| 700 | 1 | |a Vacca, Alessandra |e investigator |4 oth | |
| 700 | 1 | |a Sampaio-Barros, Percival D |e investigator |4 oth | |
| 700 | 1 | |a Stamp, Lisa |e investigator |4 oth | |
| 700 | 1 | |a Solanki, Kamal |e investigator |4 oth | |
| 700 | 1 | |a Veale, Douglas |e investigator |4 oth | |
| 700 | 1 | |a Loyo, Esthela |e investigator |4 oth | |
| 700 | 1 | |a Tineo, Carmen |e investigator |4 oth | |
| 700 | 1 | |a Toloza, Sergio |e investigator |4 oth | |
| 700 | 1 | |a Li, Mengtao |e investigator |4 oth | |
| 700 | 1 | |a Mohamed, Walid Ahmed Abdel Atty |e investigator |4 oth | |
| 700 | 1 | |a Olas, Jacek |e investigator |4 oth | |
| 700 | 1 | |a Oksel, Fahrettin |e investigator |4 oth | |
| 700 | 1 | |a Yargucu, Figen |e investigator |4 oth | |
| 700 | 1 | |a Tanaseanu, Cristina-Mihaela |e investigator |4 oth | |
| 700 | 1 | |a Foti, Rosario |e investigator |4 oth | |
| 700 | 1 | |a Ancuta, Codrina |e investigator |4 oth | |
| 700 | 1 | |a Furst, Daniel E |e investigator |4 oth | |
| 700 | 1 | |a Maurer, Britta |e investigator |4 oth | |
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