Evaluation of simple laboratory parameters in SARS-CoV-2 infection : the role of ratios
BACKGROUND: The real predictive prognostic capacity of cellular indices (or ratios) is unclear in SARS-CoV-2 infection. This study aimed to assess the prognostic role of previously well-known laboratory indices and new ones in hospitalized COVID-19 patients.
METHODS: A retrospective observational study from March to May 2022 evaluated laboratory indices on admission (neutrophil to lymphocyte-, derived neutrophil to lymphocyte-, platelet to lymphocyte-, CRP to lymphocyte-, CRP to albumin-, fibrinogen to lymphocyte-, d-dimer to lymphocyte-, ferritin to lymphocyte-, LDH to lymphocyte-, and IL-6 to lymphocyte ratios), in patients hospitalized due to SARS-CoV2 infection to determine the association with mortality, admission to an intensive care unit (ICU), need for non-invasive mechanical ventilation (NIMV), orotracheal intubation (OTI), or combined event at 30 days follow-up.
RESULTS: A total of 1113 COVID-19 patients were evaluated with a mean age of 64.1 ± 15.9 years (58.49% male), 166 (14.91%) patients died, 58 (5.21%) required ICU admission, 73 (6.56%) needed NIMV, 46 (4.23%) needed OTI, and 247 (22.19%) presented the combined event. All the ratios evaluated in this study showed statistical significance in the univariate analysis for mortality and combined event; however, only d-dimer to lymphocyte ratio >0.6 presented an independent association in the multivariate analysis for 30-day mortality (adjusted OR 2.32; p = .047) and 30-day combined event (adjusted OR 2.62; p = .014).
CONCLUSIONS: Laboratory indices might be a potential biomarker for better prognosis stratification in hospitalized COVID-19 patients. d-Dimer to lymphocyte ratio presents an independent association for 30-day mortality and 30-day adverse outcomes in hospitalized COVID-19 patients.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2022 |
|---|---|
| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:54 |
|---|---|
| Enthalten in: |
Infectious diseases (London, England) - 54(2022), 12 vom: 12. Dez., Seite 924-933 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Oblitas, Crhistian-Mario [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
9007-73-2 |
|---|
| Anmerkungen: |
Date Completed 20.10.2022 Date Revised 26.10.2022 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1080/23744235.2022.2131902 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM347371515 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM347371515 | ||
| 003 | DE-627 | ||
| 005 | 20231226033649.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1080/23744235.2022.2131902 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1157.xml |
| 035 | |a (DE-627)NLM347371515 | ||
| 035 | |a (NLM)36221980 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Oblitas, Crhistian-Mario |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Evaluation of simple laboratory parameters in SARS-CoV-2 infection |b the role of ratios |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 20.10.2022 | ||
| 500 | |a Date Revised 26.10.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: The real predictive prognostic capacity of cellular indices (or ratios) is unclear in SARS-CoV-2 infection. This study aimed to assess the prognostic role of previously well-known laboratory indices and new ones in hospitalized COVID-19 patients | ||
| 520 | |a METHODS: A retrospective observational study from March to May 2022 evaluated laboratory indices on admission (neutrophil to lymphocyte-, derived neutrophil to lymphocyte-, platelet to lymphocyte-, CRP to lymphocyte-, CRP to albumin-, fibrinogen to lymphocyte-, d-dimer to lymphocyte-, ferritin to lymphocyte-, LDH to lymphocyte-, and IL-6 to lymphocyte ratios), in patients hospitalized due to SARS-CoV2 infection to determine the association with mortality, admission to an intensive care unit (ICU), need for non-invasive mechanical ventilation (NIMV), orotracheal intubation (OTI), or combined event at 30 days follow-up | ||
| 520 | |a RESULTS: A total of 1113 COVID-19 patients were evaluated with a mean age of 64.1 ± 15.9 years (58.49% male), 166 (14.91%) patients died, 58 (5.21%) required ICU admission, 73 (6.56%) needed NIMV, 46 (4.23%) needed OTI, and 247 (22.19%) presented the combined event. All the ratios evaluated in this study showed statistical significance in the univariate analysis for mortality and combined event; however, only d-dimer to lymphocyte ratio >0.6 presented an independent association in the multivariate analysis for 30-day mortality (adjusted OR 2.32; p = .047) and 30-day combined event (adjusted OR 2.62; p = .014) | ||
| 520 | |a CONCLUSIONS: Laboratory indices might be a potential biomarker for better prognosis stratification in hospitalized COVID-19 patients. d-Dimer to lymphocyte ratio presents an independent association for 30-day mortality and 30-day adverse outcomes in hospitalized COVID-19 patients | ||
| 650 | 4 | |a Observational Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Biomarkers | |
| 650 | 4 | |a COVID19 | |
| 650 | 4 | |a SARS-CoV-2 | |
| 650 | 4 | |a mortality | |
| 650 | 4 | |a ratios | |
| 650 | 7 | |a Interleukin-6 |2 NLM | |
| 650 | 7 | |a RNA, Viral |2 NLM | |
| 650 | 7 | |a Biomarkers |2 NLM | |
| 650 | 7 | |a Ferritins |2 NLM | |
| 650 | 7 | |a 9007-73-2 |2 NLM | |
| 650 | 7 | |a Albumins |2 NLM | |
| 700 | 1 | |a Galeano-Valle, Francisco |e verfasserin |4 aut | |
| 700 | 1 | |a Cuenca-Carvajal, Carmen |e verfasserin |4 aut | |
| 700 | 1 | |a Piqueras-Ruiz, Sandra |e verfasserin |4 aut | |
| 700 | 1 | |a Alonso-Beato, Rubén |e verfasserin |4 aut | |
| 700 | 1 | |a Alejandre-de-Oña, Álvaro |e verfasserin |4 aut | |
| 700 | 1 | |a Carrascosa-Fernández, Paula |e verfasserin |4 aut | |
| 700 | 1 | |a Chacón Moreno, Agustín-Diego |e verfasserin |4 aut | |
| 700 | 1 | |a Parra-Virto, Alejandro |e verfasserin |4 aut | |
| 700 | 1 | |a Pérez Sanz, María-Teresa |e verfasserin |4 aut | |
| 700 | 1 | |a Abarca Casas, Laura |e verfasserin |4 aut | |
| 700 | 1 | |a Millán-Nohales, Clara |e verfasserin |4 aut | |
| 700 | 1 | |a Álvarez-Sala-Walther, Luis |e verfasserin |4 aut | |
| 700 | 1 | |a Demelo-Rodríguez, Pablo |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Infectious diseases (London, England) |d 2015 |g 54(2022), 12 vom: 12. Dez., Seite 924-933 |w (DE-627)NLM242918921 |x 2374-4243 |7 nnns |
| 773 | 1 | 8 | |g volume:54 |g year:2022 |g number:12 |g day:12 |g month:12 |g pages:924-933 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1080/23744235.2022.2131902 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 54 |j 2022 |e 12 |b 12 |c 12 |h 924-933 | ||