Preparation of particle-attached microneedles using a dry coating process
Copyright © 2022. Published by Elsevier B.V..
The standard process for manufacturing microneedles containing API requires a way to process the API, including dissolving the API in a co-solvent and a drying process. In this study, the authors introduce a novel microneedle system that involves physically attaching API particles to the biocompatible adhesive surface of the microneedles. To manufacture particle-attached microneedles, an adhesive surface was prepared by coating polydimethylsiloxane (PDMS) mixed with an elastomer base and a curing agent at a ratio of 40:1 (PDMS40) onto polylactic acid microneedles (PLA), and then attaching ovalbumin (OVA) particles with a mean diameter of 10 μm to the PDMS adhesive layer. The OVA particles were delivered for 5 min into porcine skin with a delivery efficiency of 93% ex vivo and into mouse skin with a delivery efficiency of over 90% in vivo. Finally, mouse experiments with OVA particle-attached microneedles showed a value of OVA antibody titer similar to that produced by intramuscular administration. Particle-attached microneedles are a novel microneedle system with a dry coating process and rapid API delivery into the skin. Particle-attached microneedles can provide a wide range of applications for administering drugs and vaccines.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:351 |
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| Enthalten in: |
Journal of controlled release : official journal of the Controlled Release Society - 351(2022) vom: 15. Nov., Seite 1003-1016 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Choi, Jeong-Eun [VerfasserIn] |
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| Links: |
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| Themen: |
63148-62-9 |
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| Anmerkungen: |
Date Completed 15.11.2022 Date Revised 17.11.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.jconrel.2022.10.003 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM347314120 |
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| 520 | |a Copyright © 2022. Published by Elsevier B.V. | ||
| 520 | |a The standard process for manufacturing microneedles containing API requires a way to process the API, including dissolving the API in a co-solvent and a drying process. In this study, the authors introduce a novel microneedle system that involves physically attaching API particles to the biocompatible adhesive surface of the microneedles. To manufacture particle-attached microneedles, an adhesive surface was prepared by coating polydimethylsiloxane (PDMS) mixed with an elastomer base and a curing agent at a ratio of 40:1 (PDMS40) onto polylactic acid microneedles (PLA), and then attaching ovalbumin (OVA) particles with a mean diameter of 10 μm to the PDMS adhesive layer. The OVA particles were delivered for 5 min into porcine skin with a delivery efficiency of 93% ex vivo and into mouse skin with a delivery efficiency of over 90% in vivo. Finally, mouse experiments with OVA particle-attached microneedles showed a value of OVA antibody titer similar to that produced by intramuscular administration. Particle-attached microneedles are a novel microneedle system with a dry coating process and rapid API delivery into the skin. Particle-attached microneedles can provide a wide range of applications for administering drugs and vaccines | ||
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| 650 | 4 | |a Dry coating | |
| 650 | 4 | |a Particle-attached microneedles | |
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| 650 | 4 | |a Polydimethylsiloxane | |
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| 700 | 1 | |a Kim, Suwan |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Ji Seok |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Mun-Jin |e verfasserin |4 aut | |
| 700 | 1 | |a Chung, Hyeon Woo |e verfasserin |4 aut | |
| 700 | 1 | |a Baek, Seung-Ki |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Jae Myun |e verfasserin |4 aut | |
| 700 | 1 | |a Park, Jung-Hwan |e verfasserin |4 aut | |
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