Anticancer potential of oroxylin A : from mechanistic insight to synergistic perspectives
© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature..
Oroxylin A (OA), a well-known constituent of the root of Scutellariae plants, has been used in ethnomedicine already for centuries in treating various neoplastic disorders. However, only recent molecular studies have revealed the different mechanisms behind its action, demonstrating antiproliferative, anti-inflammatory, and proapoptotic effects, restricting also the spread of cancer cells to distant organs. A variety of cellular targets and modulated signal transduction pathways regulated by OA have been determined in diverse cells derived from different malignant tissues. In this review article, these anticancer activities are thoroughly described, representing OA as a potential lead structure for the design of novel more potent anticancer medicines. In addition, co-effects of this natural compound with conventional anticancer agents are analyzed and the advantages provided by nanotechnological methods for more efficient application of OA are discussed. In this way, OA might represent an excellent example of using ethnopharmacological knowledge for designing modern medicines.
| Errataetall: |
ErratumIn: Naunyn Schmiedebergs Arch Pharmacol. 2024 Apr 15;:. - PMID 38619590 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:396 |
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| Enthalten in: |
Naunyn-Schmiedeberg's archives of pharmacology - 396(2023), 2 vom: 14. Feb., Seite 191-212 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Tuli, Hardeep Singh [VerfasserIn] |
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| Links: |
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| Themen: |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one |
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| Anmerkungen: |
Date Completed 12.01.2023 Date Revised 15.04.2024 published: Print-Electronic ErratumIn: Naunyn Schmiedebergs Arch Pharmacol. 2024 Apr 15;:. - PMID 38619590 Citation Status MEDLINE |
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| doi: |
10.1007/s00210-022-02298-0 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Oroxylin A (OA), a well-known constituent of the root of Scutellariae plants, has been used in ethnomedicine already for centuries in treating various neoplastic disorders. However, only recent molecular studies have revealed the different mechanisms behind its action, demonstrating antiproliferative, anti-inflammatory, and proapoptotic effects, restricting also the spread of cancer cells to distant organs. A variety of cellular targets and modulated signal transduction pathways regulated by OA have been determined in diverse cells derived from different malignant tissues. In this review article, these anticancer activities are thoroughly described, representing OA as a potential lead structure for the design of novel more potent anticancer medicines. In addition, co-effects of this natural compound with conventional anticancer agents are analyzed and the advantages provided by nanotechnological methods for more efficient application of OA are discussed. In this way, OA might represent an excellent example of using ethnopharmacological knowledge for designing modern medicines | ||
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