Adjuvant diagnosis of tuberculosis in hemodialysis patients using fourth generation interferon γ releasing assay
© 2022 International Society for Apheresis and Japanese Society for Apheresis..
INTRODUCTION: Dialysis patients have a 10-25 times higher risk of reactivation of tuberculosis (TB). In this study, we investigated the diagnostic ability of QuantiFERON (QFT)-plus for TB in hemodialysis patients. QFT-plus, an interferon gamma release assay, is characterized by its use of CD4 and CD8 T cell signals.
METHODS: Hemodialysis patients aged 20 years or older who underwent QFT-plus measurement in our hospital were included, inclusion criteria being fever above 37°C, high inflammatory response, and infiltrative pulmonary shadows.
RESULTS: Forty-six patients were enrolled. Of these, 15% were QFT positive, 4% were diagnosed with active TB, 76% were QFT negative, 8% had inconclusive results. Sensitivity, specificity, positive predictive value, and negative predictive value were 100%, 87.5%, 28%, and 100%, respectively.
CONCLUSIONS: QFT-plus may be useful for the diagnosis of active TB in dialysis patients. Further studies in cohorts with larger sample sizes are expected.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:27 |
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| Enthalten in: |
Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy - 27(2023), 3 vom: 21. Juni, Seite 435-441 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Chinen, Miria [VerfasserIn] |
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| Links: |
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| Themen: |
82115-62-6 |
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| Anmerkungen: |
Date Completed 28.04.2023 Date Revised 28.04.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/1744-9987.13939 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM347205321 |
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| 245 | 1 | 0 | |a Adjuvant diagnosis of tuberculosis in hemodialysis patients using fourth generation interferon γ releasing assay |
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| 500 | |a Date Revised 28.04.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2022 International Society for Apheresis and Japanese Society for Apheresis. | ||
| 520 | |a INTRODUCTION: Dialysis patients have a 10-25 times higher risk of reactivation of tuberculosis (TB). In this study, we investigated the diagnostic ability of QuantiFERON (QFT)-plus for TB in hemodialysis patients. QFT-plus, an interferon gamma release assay, is characterized by its use of CD4 and CD8 T cell signals | ||
| 520 | |a METHODS: Hemodialysis patients aged 20 years or older who underwent QFT-plus measurement in our hospital were included, inclusion criteria being fever above 37°C, high inflammatory response, and infiltrative pulmonary shadows | ||
| 520 | |a RESULTS: Forty-six patients were enrolled. Of these, 15% were QFT positive, 4% were diagnosed with active TB, 76% were QFT negative, 8% had inconclusive results. Sensitivity, specificity, positive predictive value, and negative predictive value were 100%, 87.5%, 28%, and 100%, respectively | ||
| 520 | |a CONCLUSIONS: QFT-plus may be useful for the diagnosis of active TB in dialysis patients. Further studies in cohorts with larger sample sizes are expected | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a dialysis | |
| 650 | 4 | |a interferon γ releasing assay | |
| 650 | 4 | |a latent tuberculosis infection | |
| 650 | 4 | |a tuberculosis | |
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| 700 | 1 | |a Sakamoto, Emi |e verfasserin |4 aut | |
| 700 | 1 | |a Noguchi, Haruka |e verfasserin |4 aut | |
| 700 | 1 | |a Suzuki, Mikako |e verfasserin |4 aut | |
| 700 | 1 | |a Kondo, Isao |e verfasserin |4 aut | |
| 700 | 1 | |a Niikura, Takahito |e verfasserin |4 aut | |
| 700 | 1 | |a Arai, Yohei |e verfasserin |4 aut | |
| 700 | 1 | |a Suzuki, Minami |e verfasserin |4 aut | |
| 700 | 1 | |a Hinoshita, Fumihiko |e verfasserin |4 aut | |
| 700 | 1 | |a Takano, Hideki |e verfasserin |4 aut | |
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