A non-canonical retina-ipRGCs-SCN-PVT visual pathway for mediating contagious itch behavior
Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved..
Contagious itch behavior informs conspecifics of adverse environment and is crucial for the survival of social animals. Gastrin-releasing peptide (GRP) and its receptor (GRPR) in the suprachiasmatic nucleus (SCN) of the hypothalamus mediates contagious itch behavior in mice. Here, we show that intrinsically photosensitive retina ganglion cells (ipRGCs) convey visual itch information, independently of melanopsin, from the retina to GRP neurons via PACAP-PAC1R signaling. Moreover, GRPR neurons relay itch information to the paraventricular nucleus of the thalamus (PVT). Surprisingly, neither the visual cortex nor superior colliculus is involved in contagious itch. In vivo calcium imaging and extracellular recordings reveal contagious itch-specific neural dynamics of GRPR neurons. Thus, we propose that the retina-ipRGC-SCN-PVT pathway constitutes a previously unknown visual pathway that probably evolved for motion vision that encodes salient environmental cues and enables animals to imitate behaviors of conspecifics as an anticipatory mechanism to cope with adverse conditions.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:41 |
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| Enthalten in: |
Cell reports - 41(2022), 1 vom: 04. Okt., Seite 111444 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Gao, Fang [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 07.10.2022 Date Revised 15.11.2022 published: Print Citation Status MEDLINE |
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| doi: |
10.1016/j.celrep.2022.111444 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM347136656 |
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| 100 | 1 | |a Gao, Fang |e verfasserin |4 aut | |
| 245 | 1 | 2 | |a A non-canonical retina-ipRGCs-SCN-PVT visual pathway for mediating contagious itch behavior |
| 264 | 1 | |c 2022 | |
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| 500 | |a Date Completed 07.10.2022 | ||
| 500 | |a Date Revised 15.11.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a Contagious itch behavior informs conspecifics of adverse environment and is crucial for the survival of social animals. Gastrin-releasing peptide (GRP) and its receptor (GRPR) in the suprachiasmatic nucleus (SCN) of the hypothalamus mediates contagious itch behavior in mice. Here, we show that intrinsically photosensitive retina ganglion cells (ipRGCs) convey visual itch information, independently of melanopsin, from the retina to GRP neurons via PACAP-PAC1R signaling. Moreover, GRPR neurons relay itch information to the paraventricular nucleus of the thalamus (PVT). Surprisingly, neither the visual cortex nor superior colliculus is involved in contagious itch. In vivo calcium imaging and extracellular recordings reveal contagious itch-specific neural dynamics of GRPR neurons. Thus, we propose that the retina-ipRGC-SCN-PVT pathway constitutes a previously unknown visual pathway that probably evolved for motion vision that encodes salient environmental cues and enables animals to imitate behaviors of conspecifics as an anticipatory mechanism to cope with adverse conditions | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a CP: Neuroscience | |
| 650 | 4 | |a GRP | |
| 650 | 4 | |a GRPR | |
| 650 | 4 | |a PACAP | |
| 650 | 4 | |a SCN | |
| 650 | 4 | |a contagious itch behavior | |
| 650 | 4 | |a ipRGCs | |
| 650 | 4 | |a itch stimuli | |
| 650 | 4 | |a neural dynamics | |
| 650 | 4 | |a scratching motion | |
| 650 | 4 | |a stress | |
| 650 | 7 | |a Pituitary Adenylate Cyclase-Activating Polypeptide |2 NLM | |
| 650 | 7 | |a Gastrin-Releasing Peptide |2 NLM | |
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| 650 | 7 | |a Calcium |2 NLM | |
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| 700 | 1 | |a Ma, Jun |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Yao-Qing |e verfasserin |4 aut | |
| 700 | 1 | |a Gao, Xiao-Fei |e verfasserin |4 aut | |
| 700 | 1 | |a Bai, Yang |e verfasserin |4 aut | |
| 700 | 1 | |a Sun, Yi |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Juan |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Xianyu |e verfasserin |4 aut | |
| 700 | 1 | |a Barry, Devin M |e verfasserin |4 aut | |
| 700 | 1 | |a Wilhelm, Steven |e verfasserin |4 aut | |
| 700 | 1 | |a Piccinni-Ash, Tyler |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Na |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Dongyang |e verfasserin |4 aut | |
| 700 | 1 | |a Ross, Rachel A |e verfasserin |4 aut | |
| 700 | 1 | |a Hao, Yan |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Xu |e verfasserin |4 aut | |
| 700 | 1 | |a Jia, Jin-Jing |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Qianyi |e verfasserin |4 aut | |
| 700 | 1 | |a Zheng, Hao |e verfasserin |4 aut | |
| 700 | 1 | |a van Nispen, Johan |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Jun |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Hui |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Jiayi |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Yun-Qing |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Zhou-Feng |e verfasserin |4 aut | |
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