Association of HIV infection with clinical features and outcomes of patients with aortic aneurysms
Data on the characteristics and outcomes of hospitalized patients with aortic aneurysms (AA) and HIV remain scarce. This is a cohort study of hospitalized adult patients with a diagnosis of AA from 2013 to 2019 using the US National Inpatient Readmission Database. Patients with a diagnosis of HIV were identified. Our outcomes included trends in hospitalizations and comparison of clinical characteristics, complications, and mortality in patients with AA and HIV compared to those without HIV. Among 1,905,837 hospitalized patients with AA, 4416 (0.23%) were living with HIV. There was an overall age-adjusted increase in the rate of HIV among patients hospitalized with AA over the years (14-29 per 10,000 person-years; age-adjusted p-trend < 0.001). Patients with AA and HIV were younger than those without HIV (median age: 60 vs 76 years, p < 0.001) and were less likely to have a history of smoking, hypertension, dyslipidemia, diabetes mellitus, and obesity. Thoracic aortic aneurysms were more prevalent in those with HIV (37.5% vs 26.7%, p < 0.001). On multivariable logistic regression, HIV was not associated with increased risk of aortic rupture (OR: 0.79; 95% CI: 0.61-1.01, p = 0.06), acute aortic dissection (OR: 0.73; 95% CI: 0.51-1.06, p = 0.3), readmissions (OR: 1.04; 95% CI: 0.95-1.13, p = 0.4), or aortic repair (OR: 0.89; 95% CI: 0.79-1.00, p = 0.05). Hospitalized patients with AA and HIV had a lower crude mortality rate compared to those without HIV (OR: 0.75 (0.63-0.91), p = 0.003). Hospitalized patients with AA and HIV likely constitute a distinct group of patients with AA; they are younger, have fewer traditional cardiovascular risk factors, and a higher rate of thoracic aorta involvement. Differences in clinical features may account for the lower mortality rate observed in patients with AA and HIV compared to those without HIV.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2022 |
---|---|
Erschienen: |
2022 |
Enthalten in: |
Zur Gesamtaufnahme - volume:27 |
---|---|
Enthalten in: |
Vascular medicine (London, England) - 27(2022), 6 vom: 03. Dez., Seite 557-564 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Chehab, Omar [VerfasserIn] |
---|
Links: |
---|
Themen: |
Aortic aneurysm |
---|
Anmerkungen: |
Date Completed 15.12.2022 Date Revised 23.01.2023 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.1177/1358863X221122577 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM347062539 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM347062539 | ||
003 | DE-627 | ||
005 | 20231226032928.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231226s2022 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1177/1358863X221122577 |2 doi | |
028 | 5 | 2 | |a pubmed24n1156.xml |
035 | |a (DE-627)NLM347062539 | ||
035 | |a (NLM)36190774 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Chehab, Omar |e verfasserin |4 aut | |
245 | 1 | 0 | |a Association of HIV infection with clinical features and outcomes of patients with aortic aneurysms |
264 | 1 | |c 2022 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 15.12.2022 | ||
500 | |a Date Revised 23.01.2023 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Data on the characteristics and outcomes of hospitalized patients with aortic aneurysms (AA) and HIV remain scarce. This is a cohort study of hospitalized adult patients with a diagnosis of AA from 2013 to 2019 using the US National Inpatient Readmission Database. Patients with a diagnosis of HIV were identified. Our outcomes included trends in hospitalizations and comparison of clinical characteristics, complications, and mortality in patients with AA and HIV compared to those without HIV. Among 1,905,837 hospitalized patients with AA, 4416 (0.23%) were living with HIV. There was an overall age-adjusted increase in the rate of HIV among patients hospitalized with AA over the years (14-29 per 10,000 person-years; age-adjusted p-trend < 0.001). Patients with AA and HIV were younger than those without HIV (median age: 60 vs 76 years, p < 0.001) and were less likely to have a history of smoking, hypertension, dyslipidemia, diabetes mellitus, and obesity. Thoracic aortic aneurysms were more prevalent in those with HIV (37.5% vs 26.7%, p < 0.001). On multivariable logistic regression, HIV was not associated with increased risk of aortic rupture (OR: 0.79; 95% CI: 0.61-1.01, p = 0.06), acute aortic dissection (OR: 0.73; 95% CI: 0.51-1.06, p = 0.3), readmissions (OR: 1.04; 95% CI: 0.95-1.13, p = 0.4), or aortic repair (OR: 0.89; 95% CI: 0.79-1.00, p = 0.05). Hospitalized patients with AA and HIV had a lower crude mortality rate compared to those without HIV (OR: 0.75 (0.63-0.91), p = 0.003). Hospitalized patients with AA and HIV likely constitute a distinct group of patients with AA; they are younger, have fewer traditional cardiovascular risk factors, and a higher rate of thoracic aorta involvement. Differences in clinical features may account for the lower mortality rate observed in patients with AA and HIV compared to those without HIV | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a HIV infection | |
650 | 4 | |a aortic aneurysm | |
650 | 4 | |a aortic dissection | |
650 | 4 | |a aortic rupture | |
700 | 1 | |a Kanj, Amjad |e verfasserin |4 aut | |
700 | 1 | |a Zeitoun, Ralph |e verfasserin |4 aut | |
700 | 1 | |a Mir, Tanveer |e verfasserin |4 aut | |
700 | 1 | |a Shafi, Irfan |e verfasserin |4 aut | |
700 | 1 | |a Pahuja, Mohit |e verfasserin |4 aut | |
700 | 1 | |a Briasoulis, Alexandros |e verfasserin |4 aut | |
700 | 1 | |a Doria de Vasconcellos, Henrique |e verfasserin |4 aut | |
700 | 1 | |a Minhas, Anum |e verfasserin |4 aut | |
700 | 1 | |a Varadarajan, Vinithra |e verfasserin |4 aut | |
700 | 1 | |a Wu, Colin |e verfasserin |4 aut | |
700 | 1 | |a Arbab-Zadeh, Armin |e verfasserin |4 aut | |
700 | 1 | |a Post, Wendy S |e verfasserin |4 aut | |
700 | 1 | |a Wu, Katherine C |e verfasserin |4 aut | |
700 | 1 | |a Lima, João Ac |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Vascular medicine (London, England) |d 1996 |g 27(2022), 6 vom: 03. Dez., Seite 557-564 |w (DE-627)NLM094881766 |x 1358-863X |7 nnns |
773 | 1 | 8 | |g volume:27 |g year:2022 |g number:6 |g day:03 |g month:12 |g pages:557-564 |
856 | 4 | 0 | |u http://dx.doi.org/10.1177/1358863X221122577 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 27 |j 2022 |e 6 |b 03 |c 12 |h 557-564 |