Charlson Comorbidity Index (CCI) in Diffuse Large B-cell Lymphoma : A New Approach in a Multicenter Study

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Purpose: Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of adult lymphomas. The incidence of DLBCL increases with age and has a fairly rapid fatal course without treatment. Patients often have difficulty tolerating standard chemotherapy regimens due to their comorbidities. Charlson Comorbidity Index (CCI), which is calculated by considering 19 different comorbidities, was developed in 1987 and is widely used for mortality prediction in cancer patients. Literature data on CCI and hematological malignancies are limited. Main aim in this study is to evaluate the effectiveness of CCI and compare to the International Prognostic Index (IPI) scoring system in the DLBCL patient group.

Methods: A total of 170 patients diagnosed with DLBCL between 1.1.2002- 1.12.2020 were included in the study. Statistical analyzes were performed among patients whose IPI and CCI scores were recorded by considering baseline data.

Results: The median age of patients was 58 (range: 17-84). Thirty-five (20.6%) patients had stage III and 76 (44.7%) had stage IV disease. When the CCI, IPI and ECOG scores were compared with the mortality status of the patients as a reference, AUCs were resulted as 0.628 (95% CI: 0.506-0.749), 0.563 (95% CI: 0.484-0.639) and 0.672 (95% CI: 0.596-0.743), respectively. There was no significant difference between the ROC curves of CCI, IPI and ECOG scores. Patients with a CCI score of ≥ 4 had shorter OS comperad to those with a score of < 4.

Conclusion: Rather than claiming that CCI is superior to IPI, ECOG or another scoring system in a single-center patient population, it should be stated that CCI is also an effective scoring system in patients diagnosed with DLBCL.

Supplementary Information: The online version contains supplementary material available at 10.1007/s12288-022-01567-5.

Medienart:

E-Artikel

Erscheinungsjahr:

2023

Erschienen:

2023

Enthalten in:

Zur Gesamtaufnahme - volume:39

Enthalten in:

Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion - 39(2023), 2 vom: 26. Apr., Seite 191-199

Sprache:

Englisch

Beteiligte Personen:

Eren, Rafet [VerfasserIn]
Serin, Istemi [VerfasserIn]
Atak, Suheyla [VerfasserIn]
Pirdal, Betul Zehra [VerfasserIn]
Nizam, Nihan [VerfasserIn]
Gemici, Aliihsan [VerfasserIn]
Aydın, Demet [VerfasserIn]
Demirel, Naciye [VerfasserIn]
Dogan, Esma Evrim [VerfasserIn]
Yokus, Osman [VerfasserIn]

Links:

Volltext

Themen:

Charlson Comorbidity Index
Diffuse large B-cell lymphoma
Efficacy
Journal Article
Prognosis

Anmerkungen:

Date Revised 03.04.2023

published: Print-Electronic

Citation Status PubMed-not-MEDLINE

doi:

10.1007/s12288-022-01567-5

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM347017223