Triggering of ST-elevation myocardial infarction by ultrafine particles in New York : Changes following Tier 3 vehicle introduction
Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved..
BACKGROUND: Previously, we found increased rates of ST-elevation myocardial infarction (STEMI) associated with increased ultrafine particle (UFP; <100 nm) concentrations in the previous few hours in Rochester, New York. Relative rates were higher after air quality policies and a recession reduced pollutant concentrations (2014-2016 versus 2005-2013), suggesting PM composition had changed and the same PM mass concentration had become more toxic. Tier 3 light duty vehicles, which should produce less primary organic aerosols and oxidizable gaseous compounds, likely making PM less toxic, were introduced in 2017. Thus, we hypothesized we would observe a lower relative STEMI rate in 2017-2019 than 2014-2016.
METHODS: Using STEMI events treated at the University of Rochester Medical Center (2014-2019), UFP and other pollutants measured in Rochester, a case-crossover design, and conditional logistic regression models, we estimated the rate of STEMI associated with increased UFP and other pollutants in the previous hours and days in the 2014-2016 and 2017-2019 periods.
RESULTS: An increased rate of STEMI was associated with each 3111 particles/cm3 increase in UFP concentration in the previous hour in 2014-2016 (lag hour 0: OR = 1.22; 95% CI = 1.06, 1.39), but not in 2017-2019 (OR = 0.94; 95% CI = 0.80, 1.10). There were similar patterns for black carbon, UFP11-50nm, and UFP51-100nm. In contrast, increased rates of STEMI were associated with each 0.6 ppb increase in SO2 concentration in the previous 120 h in both periods (2014-2016: OR = 1.26, 95% CI = 1.03, 1.55; 2017-2019: OR = 1.21, 95% CI = 0.87, 1.68).
CONCLUSIONS: Greater rates of STEMI were associated with short term increases in concentrations of UFP and other motor vehicle related pollutants before Tier 3 introduction (2014-2016), but not afterwards (2017-2019). This change may be due to changes in PM composition after Tier 3 introduction, as well as to increased exposure misclassification and greater underestimation of effects from 2017 to 2019.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:216 |
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| Enthalten in: |
Environmental research - 216(2023), Pt 1 vom: 01. Jan., Seite 114445 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Yount, Catherine S [VerfasserIn] |
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| Links: |
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| Themen: |
Air Pollutants |
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| Anmerkungen: |
Date Completed 29.11.2022 Date Revised 30.01.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.envres.2022.114445 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM346973953 |
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| 100 | 1 | |a Yount, Catherine S |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Triggering of ST-elevation myocardial infarction by ultrafine particles in New York |b Changes following Tier 3 vehicle introduction |
| 264 | 1 | |c 2023 | |
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| 500 | |a Date Revised 30.01.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a BACKGROUND: Previously, we found increased rates of ST-elevation myocardial infarction (STEMI) associated with increased ultrafine particle (UFP; <100 nm) concentrations in the previous few hours in Rochester, New York. Relative rates were higher after air quality policies and a recession reduced pollutant concentrations (2014-2016 versus 2005-2013), suggesting PM composition had changed and the same PM mass concentration had become more toxic. Tier 3 light duty vehicles, which should produce less primary organic aerosols and oxidizable gaseous compounds, likely making PM less toxic, were introduced in 2017. Thus, we hypothesized we would observe a lower relative STEMI rate in 2017-2019 than 2014-2016 | ||
| 520 | |a METHODS: Using STEMI events treated at the University of Rochester Medical Center (2014-2019), UFP and other pollutants measured in Rochester, a case-crossover design, and conditional logistic regression models, we estimated the rate of STEMI associated with increased UFP and other pollutants in the previous hours and days in the 2014-2016 and 2017-2019 periods | ||
| 520 | |a RESULTS: An increased rate of STEMI was associated with each 3111 particles/cm3 increase in UFP concentration in the previous hour in 2014-2016 (lag hour 0: OR = 1.22; 95% CI = 1.06, 1.39), but not in 2017-2019 (OR = 0.94; 95% CI = 0.80, 1.10). There were similar patterns for black carbon, UFP11-50nm, and UFP51-100nm. In contrast, increased rates of STEMI were associated with each 0.6 ppb increase in SO2 concentration in the previous 120 h in both periods (2014-2016: OR = 1.26, 95% CI = 1.03, 1.55; 2017-2019: OR = 1.21, 95% CI = 0.87, 1.68) | ||
| 520 | |a CONCLUSIONS: Greater rates of STEMI were associated with short term increases in concentrations of UFP and other motor vehicle related pollutants before Tier 3 introduction (2014-2016), but not afterwards (2017-2019). This change may be due to changes in PM composition after Tier 3 introduction, as well as to increased exposure misclassification and greater underestimation of effects from 2017 to 2019 | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Air pollution | |
| 650 | 4 | |a Case-crossover | |
| 650 | 4 | |a Myocardial infarction | |
| 650 | 4 | |a Ultrafine particles | |
| 650 | 7 | |a Particulate Matter |2 NLM | |
| 650 | 7 | |a Air Pollutants |2 NLM | |
| 700 | 1 | |a Utell, Mark J |e verfasserin |4 aut | |
| 700 | 1 | |a Hopke, Philip K |e verfasserin |4 aut | |
| 700 | 1 | |a Thurston, Sally W |e verfasserin |4 aut | |
| 700 | 1 | |a Lin, Shao |e verfasserin |4 aut | |
| 700 | 1 | |a Ling, Frederick S |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Yunle |e verfasserin |4 aut | |
| 700 | 1 | |a Chalupa, David |e verfasserin |4 aut | |
| 700 | 1 | |a Deng, Xinlei |e verfasserin |4 aut | |
| 700 | 1 | |a Rich, David Q |e verfasserin |4 aut | |
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