Chemically Enhanced Immunogenicity of Bacteria by Supramolecular Functionalization with an Adjuvant
© 2022 The Authors. ChemBioChem published by Wiley-VCH GmbH..
Many pathogens blunt immune responses because they lack immunogenic structural features, which typically results in disease. Here, we show evidence suggesting that pathogen immunogenicity can be chemically enhanced. Using supramolecular host-guest chemistry, we complexed onto the surface of a poorly immunogenic bacterium (Staphylococcus aureus) a TLR7 agonist-based adjuvant. "Adjuvanted" bacteria were readily recognized by macrophages and induced a more pro-inflammatory immunophenotype. Future applications of this concept could yield treatment modalities that bolster the immune system's response to pathogenic microbes.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:23 |
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| Enthalten in: |
Chembiochem : a European journal of chemical biology - 23(2022), 23 vom: 05. Dez., Seite e202200434 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Duszenko, Nikolas [VerfasserIn] |
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| Links: |
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| Themen: |
Adjuvants, Immunologic |
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| Anmerkungen: |
Date Completed 07.12.2022 Date Revised 15.04.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/cbic.202200434 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Many pathogens blunt immune responses because they lack immunogenic structural features, which typically results in disease. Here, we show evidence suggesting that pathogen immunogenicity can be chemically enhanced. Using supramolecular host-guest chemistry, we complexed onto the surface of a poorly immunogenic bacterium (Staphylococcus aureus) a TLR7 agonist-based adjuvant. "Adjuvanted" bacteria were readily recognized by macrophages and induced a more pro-inflammatory immunophenotype. Future applications of this concept could yield treatment modalities that bolster the immune system's response to pathogenic microbes | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Roestenberg, Meta |e verfasserin |4 aut | |
| 700 | 1 | |a van Leeuwen, Fijs W B |e verfasserin |4 aut | |
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