Expansion of the global RNA virome reveals diverse clades of bacteriophages
Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved..
High-throughput RNA sequencing offers broad opportunities to explore the Earth RNA virome. Mining 5,150 diverse metatranscriptomes uncovered >2.5 million RNA virus contigs. Analysis of >330,000 RNA-dependent RNA polymerases (RdRPs) shows that this expansion corresponds to a 5-fold increase of the known RNA virus diversity. Gene content analysis revealed multiple protein domains previously not found in RNA viruses and implicated in virus-host interactions. Extended RdRP phylogeny supports the monophyly of the five established phyla and reveals two putative additional bacteriophage phyla and numerous putative additional classes and orders. The dramatically expanded phylum Lenarviricota, consisting of bacterial and related eukaryotic viruses, now accounts for a third of the RNA virome. Identification of CRISPR spacer matches and bacteriolytic proteins suggests that subsets of picobirnaviruses and partitiviruses, previously associated with eukaryotes, infect prokaryotic hosts.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:185 |
|---|---|
| Enthalten in: |
Cell - 185(2022), 21 vom: 13. Okt., Seite 4023-4037.e18 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Neri, Uri [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 18.10.2022 Date Revised 25.01.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.cell.2022.08.023 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 245 | 1 | 0 | |a Expansion of the global RNA virome reveals diverse clades of bacteriophages |
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| 500 | |a Date Completed 18.10.2022 | ||
| 500 | |a Date Revised 25.01.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a High-throughput RNA sequencing offers broad opportunities to explore the Earth RNA virome. Mining 5,150 diverse metatranscriptomes uncovered >2.5 million RNA virus contigs. Analysis of >330,000 RNA-dependent RNA polymerases (RdRPs) shows that this expansion corresponds to a 5-fold increase of the known RNA virus diversity. Gene content analysis revealed multiple protein domains previously not found in RNA viruses and implicated in virus-host interactions. Extended RdRP phylogeny supports the monophyly of the five established phyla and reveals two putative additional bacteriophage phyla and numerous putative additional classes and orders. The dramatically expanded phylum Lenarviricota, consisting of bacterial and related eukaryotic viruses, now accounts for a third of the RNA virome. Identification of CRISPR spacer matches and bacteriolytic proteins suggests that subsets of picobirnaviruses and partitiviruses, previously associated with eukaryotes, infect prokaryotic hosts | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Research Support, U.S. Gov't, Non-P.H.S. | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Research Support, N.I.H., Intramural | |
| 650 | 4 | |a Bactriophage | |
| 650 | 4 | |a Functional protein annotation | |
| 650 | 4 | |a Metatranscriptomics | |
| 650 | 4 | |a RNA Virus | |
| 650 | 4 | |a RNA dependent RNA polymerase | |
| 650 | 4 | |a Viral Ecology | |
| 650 | 4 | |a Virus | |
| 650 | 4 | |a Virus - Host prediction | |
| 650 | 4 | |a viral phylogeny | |
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| 700 | 1 | |a Wolf, Yuri I |e verfasserin |4 aut | |
| 700 | 1 | |a Roux, Simon |e verfasserin |4 aut | |
| 700 | 1 | |a Camargo, Antonio Pedro |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Benjamin |e verfasserin |4 aut | |
| 700 | 1 | |a Kazlauskas, Darius |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, I Min |e verfasserin |4 aut | |
| 700 | 1 | |a Ivanova, Natalia |e verfasserin |4 aut | |
| 700 | 1 | |a Zeigler Allen, Lisa |e verfasserin |4 aut | |
| 700 | 1 | |a Paez-Espino, David |e verfasserin |4 aut | |
| 700 | 1 | |a Bryant, Donald A |e verfasserin |4 aut | |
| 700 | 1 | |a Bhaya, Devaki |e verfasserin |4 aut | |
| 700 | 0 | |a RNA Virus Discovery Consortium |e verfasserin |4 aut | |
| 700 | 1 | |a Krupovic, Mart |e verfasserin |4 aut | |
| 700 | 1 | |a Dolja, Valerian V |e verfasserin |4 aut | |
| 700 | 1 | |a Kyrpides, Nikos C |e verfasserin |4 aut | |
| 700 | 1 | |a Koonin, Eugene V |e verfasserin |4 aut | |
| 700 | 1 | |a Gophna, Uri |e verfasserin |4 aut | |
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