Developing CIRdb as a catalog of natural genetic variation in the Canary Islanders
© 2022. The Author(s)..
The current inhabitants of the Canary Islands have a unique genetic makeup in the European diversity landscape due to the existence of African footprints from recent admixture events, especially of North African components (> 20%). The underrepresentation of non-Europeans in genetic studies and the sizable North African ancestry, which is nearly absent from all existing catalogs of worldwide genetic diversity, justify the need to develop CIRdb, a population-specific reference catalog of natural genetic variation in the Canary Islanders. Based on array genotyping of the selected unrelated donors and comparisons against available datasets from European, sub-Saharan, and North African populations, we illustrate the intermediate genetic differentiation of Canary Islanders between Europeans and North Africans and the existence of within-population differences that are likely driven by genetic isolation. Here we describe the overall design and the methods that are being implemented to further develop CIRdb. This resource will help to strengthen the implementation of Precision Medicine in this population by contributing to increase the diversity in genetic studies. Among others, this will translate into improved ability to fine map disease genes and simplify the identification of causal variants and estimate the prevalence of unattended Mendelian diseases.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
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| Enthalten in: |
Scientific reports - 12(2022), 1 vom: 27. Sept., Seite 16132 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Díaz-de Usera, Ana [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 29.09.2022 Date Revised 07.12.2022 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1038/s41598-022-20442-x |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM346836395 |
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| 520 | |a © 2022. The Author(s). | ||
| 520 | |a The current inhabitants of the Canary Islands have a unique genetic makeup in the European diversity landscape due to the existence of African footprints from recent admixture events, especially of North African components (> 20%). The underrepresentation of non-Europeans in genetic studies and the sizable North African ancestry, which is nearly absent from all existing catalogs of worldwide genetic diversity, justify the need to develop CIRdb, a population-specific reference catalog of natural genetic variation in the Canary Islanders. Based on array genotyping of the selected unrelated donors and comparisons against available datasets from European, sub-Saharan, and North African populations, we illustrate the intermediate genetic differentiation of Canary Islanders between Europeans and North Africans and the existence of within-population differences that are likely driven by genetic isolation. Here we describe the overall design and the methods that are being implemented to further develop CIRdb. This resource will help to strengthen the implementation of Precision Medicine in this population by contributing to increase the diversity in genetic studies. Among others, this will translate into improved ability to fine map disease genes and simplify the identification of causal variants and estimate the prevalence of unattended Mendelian diseases | ||
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| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 700 | 1 | |a Rubio-Rodríguez, Luis A |e verfasserin |4 aut | |
| 700 | 1 | |a Muñoz-Barrera, Adrián |e verfasserin |4 aut | |
| 700 | 1 | |a Lorenzo-Salazar, Jose M |e verfasserin |4 aut | |
| 700 | 1 | |a Guillen-Guio, Beatriz |e verfasserin |4 aut | |
| 700 | 1 | |a Jáspez, David |e verfasserin |4 aut | |
| 700 | 1 | |a Corrales, Almudena |e verfasserin |4 aut | |
| 700 | 1 | |a Íñigo-Campos, Antonio |e verfasserin |4 aut | |
| 700 | 1 | |a García-Olivares, Víctor |e verfasserin |4 aut | |
| 700 | 1 | |a Rodríguez Pérez, María Del Cristo |e verfasserin |4 aut | |
| 700 | 1 | |a Marcelino-Rodríguez, Itahisa |e verfasserin |4 aut | |
| 700 | 1 | |a Cabrera de León, Antonio |e verfasserin |4 aut | |
| 700 | 1 | |a González-Montelongo, Rafaela |e verfasserin |4 aut | |
| 700 | 1 | |a Flores, Carlos |e verfasserin |4 aut | |
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